2,7-bis-(2-dimethylaminoethoxy)-fluoren-9-one | 53395-12-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,7-bis-(2-dimethylaminoethoxy)-fluoren-9-one
• 英文别名: 2,7-bis[2-(dimethylamino)ethoxy]fluoren-9-one；2,7-Bis-<2-(dimethylamino)-ethoxy>-fluoren-9-on；2,7-Bis-[2-(dimethylamino)-ethoxy]-fluoren-9-on
• CAS: 53395-12-3
• 化学式: C₂₁H₂₆N₂O₃
• 分子量: 354.449
• InChiKey: WVGDOXLWDJMWGP-UHFFFAOYSA-N

物化性质

• 沸点：
  509.7±50.0 °C(Predicted)
• 密度：
  1.156±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  26
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,7-bis-(2-dimethylaminoethoxy)-fluoren-9-one 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 、 水 为溶剂， 生成 2,7-bis-(2-dimethylaminoethoxy)-fluoren-9-ol
  参考文献：
  名称：

  双碱性取代的多环芳族化合物。一类新的抗病毒药物。2.芴酮，芴醇和芴的噻咯烷酮和相关的二元醚。

  摘要：

  DOI：

  10.1021/jm00254a020
• 作为产物：
  描述：

  2,7-二羟基-9-芴酮 、 2-氯-N,N-二甲基乙胺 生成 2,7-bis-(2-dimethylaminoethoxy)-fluoren-9-one
  参考文献：
  名称：

  双碱性取代的多环芳族化合物。一类新的抗病毒药物。2.芴酮，芴醇和芴的噻咯烷酮和相关的二元醚。

  摘要：

  DOI：

  10.1021/jm00254a020

文献信息

• Amino-substituted tricyclic derivatives and methods of use
  申请人：Schrimpf R. Michael

  公开号：US20050171079A1

  公开（公告）日：2005-08-04

  Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y 1 and Y 2 form various tricyclic cores, and R x is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives.

  其中A和B是胺基取代的侧链，Y1和Y2形成各种三环核，Rx是可选的取代基。考虑到公式(I)的化合物和组合物，以及用于治疗由α7 nAChR配体预防或改善的疾病或疾病的方法，这些方法涵盖了公式(I)的化合物和其他三环衍生物。
• 2,7-Bis-basic ethers of 9-phenanthrol and 9-loweralkoxy phenanthrol
  申请人：Richardson-Merrell Inc.

  公开号：US04169897A1

  公开（公告）日：1979-10-02

  Novel bis-basic ethers of 9-substituted phenanthrene and related 10-oxa and 10-aza derivatives, their method of preparation and their use as pharmaceutical agents for the prevention and inhibition of viral infections are disclosed.

  本发明揭示了9-取代菲的新型双碱基醚以及相关的10-氧杂和10-氮杂衍生物，其制备方法以及作为预防和抑制病毒感染的药物代理的用途。
• Amino-Substituted Tricyclic Derivatives and Methods of Use
  申请人：Schrimpf Michael R.

  公开号：US20080161281A1

  公开（公告）日：2008-07-03

  Compounds of formula (I) wherein A and B are amine-substituted sidechains, Y 1 and Y 2 form various tricyclic cores, X a and X b are C, CH, or N, as defined herein, and R x is an optional substituent. Compounds and compositions of formula (I) are contemplated as well as methods for treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands that encompass compounds of formula (I) and other tricyclic derivatives. Methods of using amino-substituted tricyclic derivatives also are described herein.

  式(I)的化合物中，A和B是胺基取代的侧链，Y1和Y2形成各种三环核心，Xa和Xb为C、CH或N，如本文所定义，R为可选取代基。本文考虑了式(I)的化合物和组合物，以及用于治疗α7 nAChR配体包括式(I)化合物和其他三环衍生物的条件或障碍的方法。本文还描述了使用氨基取代的三环衍生物的方法。
• SAR of α7 nicotinic receptor agonists derived from tilorone: Exploration of a novel nicotinic pharmacophore
  作者：Michael R. Schrimpf、Kevin B. Sippy、Clark A. Briggs、David J. Anderson、Tao Li、Jianguo Ji、Jennifer M. Frost、Carol S. Surowy、William H. Bunnelle、Murali Gopalakrishnan、Michael D. Meyer

  DOI：10.1016/j.bmcl.2011.12.126

  日期：2012.2

  The well-known interferon-inducer tilorone was found to possess potent affinity for the agonist site of the alpha 7 neuronal nicotinic receptor (K-i = 56 nM). SAR investigations determined that both basic sidechains are essential for potent activity, however active monosubstituted derivatives can also be prepared if the flexible sidechains are replaced with conformationally rigidified cyclic amines. Analogs in which the fluorenone core is replaced with either dibenzothiophene-5,5-dioxide or xanthenone also retain potent activity. (C) 2012 Elsevier Ltd. All rights reserved.
• US4059702A
  申请人：——

  公开号：US4059702A

  公开（公告）日：1977-11-22