4,4'-bis(2,2-bis-trimethylsilanyl-ethyl)-2,2'-bipyridine | 1300059-69-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,4'-bis(2,2-bis-trimethylsilanyl-ethyl)-2,2'-bipyridine
• 英文别名: [2-[2-[4-[2,2-Bis(trimethylsilyl)ethyl]pyridin-2-yl]pyridin-4-yl]-1-trimethylsilylethyl]-trimethylsilane；[2-[2-[4-[2,2-bis(trimethylsilyl)ethyl]pyridin-2-yl]pyridin-4-yl]-1-trimethylsilylethyl]-trimethylsilane
• CAS: 1300059-69-1
• 化学式: C₂₆H₄₈N₂Si₄
• 分子量: 501.023
• InChiKey: LOPSZTYWBWGQFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.4
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  oxodiperoxidomolybdenum(IV) aqua 、 4,4'-bis(2,2-bis-trimethylsilanyl-ethyl)-2,2'-bipyridine 以 甲醇 为溶剂， 生成 (4,4'-bis(2,2-bis-trimethylsilanyl-ethyl)-2,2'-bipyridine)oxodiperoxidomolybdenum(VI)
  参考文献：
  名称：

  Olefin epoxidation in solventless conditions and apolar media catalysed by specialised oxodiperoxomolybdenum complexes

  摘要：

  The epoxidation of olefin substrates, in both apolar organic media and under solventless conditions, with aqueous hydrogen peroxide and catalysed by molybdenum complexes has been investigated. The catalysts compounds employed were the oxodiperoxomolybdenum complexes of several pyridine, 2,2'-bipyridine and pyrazole ligands with apolar functions (alkyl chains, alkyl-trimethylsilyl groups and polydimethylsiloxanyl polymer), which showed enhanced solubility in relatively apolar organic media. Both the isolated complexes and in situ preparations were catalytically active. The solubility of the new catalyst complexes appears to facilitate the catalytic activity in these systems, since activity was not observed for the analogous, insoluble complexes of unfunctionalised ligands. In these systems, the oxidant, aqueous hydrogen peroxide, forms a separate phase and the catalyst resides in the organic phase. From a green chemistry and economic perspective the elimination of organic solvents and co-catalysts from a reaction system would present advantages and, consequently, the epoxidation reaction was also investigated under solventless conditions. The 3-hexyl-5-methylpyrazole and 3-hexyl-5-heptylpyrazole complexes were found to show heightened activities, the latter being particularly efficient in these conditions, whilst bipyridines apparently inhibit the epoxidation. In addition, the mechanism of the epoxidation reaction was studied through DFT calculations for the model olefin substrate ethylene with the oxodiperoxomolybdenum complex of 3-hexyl-5-heptylpyrazole. The oxo-transfer reaction occurred by interaction of the ethylene with the peroxo ligand via the spirocyclic transition state proposed by Sharpless. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.02.004
• 作为产物：
  描述：

  4,4'-二甲基-2,2'-联吡啶 、 1-chloro-2,2-bis-trimethylsilanyl-ethane 在 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 以70%的产率得到4,4'-bis(2,2-bis-trimethylsilanyl-ethyl)-2,2'-bipyridine
  参考文献：
  名称：

  Olefin epoxidation in solventless conditions and apolar media catalysed by specialised oxodiperoxomolybdenum complexes

  摘要：

  The epoxidation of olefin substrates, in both apolar organic media and under solventless conditions, with aqueous hydrogen peroxide and catalysed by molybdenum complexes has been investigated. The catalysts compounds employed were the oxodiperoxomolybdenum complexes of several pyridine, 2,2'-bipyridine and pyrazole ligands with apolar functions (alkyl chains, alkyl-trimethylsilyl groups and polydimethylsiloxanyl polymer), which showed enhanced solubility in relatively apolar organic media. Both the isolated complexes and in situ preparations were catalytically active. The solubility of the new catalyst complexes appears to facilitate the catalytic activity in these systems, since activity was not observed for the analogous, insoluble complexes of unfunctionalised ligands. In these systems, the oxidant, aqueous hydrogen peroxide, forms a separate phase and the catalyst resides in the organic phase. From a green chemistry and economic perspective the elimination of organic solvents and co-catalysts from a reaction system would present advantages and, consequently, the epoxidation reaction was also investigated under solventless conditions. The 3-hexyl-5-methylpyrazole and 3-hexyl-5-heptylpyrazole complexes were found to show heightened activities, the latter being particularly efficient in these conditions, whilst bipyridines apparently inhibit the epoxidation. In addition, the mechanism of the epoxidation reaction was studied through DFT calculations for the model olefin substrate ethylene with the oxodiperoxomolybdenum complex of 3-hexyl-5-heptylpyrazole. The oxo-transfer reaction occurred by interaction of the ethylene with the peroxo ligand via the spirocyclic transition state proposed by Sharpless. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2011.02.004

文献信息

• Olefin epoxidation in solventless conditions and apolar media catalysed by specialised oxodiperoxomolybdenum complexes
  作者：Matthew Herbert、Francisco Montilla、Agustín Galindo

  DOI：10.1016/j.molcata.2011.02.004

  日期：2011.2.15

  The epoxidation of olefin substrates, in both apolar organic media and under solventless conditions, with aqueous hydrogen peroxide and catalysed by molybdenum complexes has been investigated. The catalysts compounds employed were the oxodiperoxomolybdenum complexes of several pyridine, 2,2'-bipyridine and pyrazole ligands with apolar functions (alkyl chains, alkyl-trimethylsilyl groups and polydimethylsiloxanyl polymer), which showed enhanced solubility in relatively apolar organic media. Both the isolated complexes and in situ preparations were catalytically active. The solubility of the new catalyst complexes appears to facilitate the catalytic activity in these systems, since activity was not observed for the analogous, insoluble complexes of unfunctionalised ligands. In these systems, the oxidant, aqueous hydrogen peroxide, forms a separate phase and the catalyst resides in the organic phase. From a green chemistry and economic perspective the elimination of organic solvents and co-catalysts from a reaction system would present advantages and, consequently, the epoxidation reaction was also investigated under solventless conditions. The 3-hexyl-5-methylpyrazole and 3-hexyl-5-heptylpyrazole complexes were found to show heightened activities, the latter being particularly efficient in these conditions, whilst bipyridines apparently inhibit the epoxidation. In addition, the mechanism of the epoxidation reaction was studied through DFT calculations for the model olefin substrate ethylene with the oxodiperoxomolybdenum complex of 3-hexyl-5-heptylpyrazole. The oxo-transfer reaction occurred by interaction of the ethylene with the peroxo ligand via the spirocyclic transition state proposed by Sharpless. (C) 2011 Elsevier B.V. All rights reserved.