(2-bromo-3,4,5,6-tetrafluorobenzene)sulfonyl chloride | 220987-96-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2-bromo-3,4,5,6-tetrafluorobenzene)sulfonyl chloride
• 英文别名: 2-bromo-3,4,5,6-tetrafluorobenzene-1-sulfonyl chloride；2-bromo-3,4,5,6-tetrafluorophenylsulfonyl chloride；2-bromo-3,4,5,6-tetrafluorobenzenesulfonyl chloride
• CAS: 220987-96-2
• 化学式: C₆BrClF₄O₂S
• 分子量: 327.481
• InChiKey: CUBSXTAOVAEONH-UHFFFAOYSA-N

物化性质

• 沸点：
  273.5±40.0 °C(Predicted)
• 密度：
  2.058±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  (2-bromo-3,4,5,6-tetrafluorobenzene)sulfonyl chloride 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 生成 2,3,4,5-Tetrafluoro-1-[(4-methoxyphenyl)aminosulfonyl]benzene
  参考文献：
  名称：

  Novel halogenated sulfonamides inhibit the growth of multidrug resistant MCF-7/ADR cancer cells

  摘要：

  In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance (MDR) phenotype of certain cells does not affect their sensitivity to these compounds. These agents belong to a family of compounds previously shown to bind irreversibly to cysteine-239 of beta-tubulin. Consistent with this mechanism of action, the cytotoxicities of these compounds appear to correlate with their ability to undergo nucleophilic aromatic substitution. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00276-0
• 作为产物：
  描述：

  2,3,4,5-四氟溴苯 在 fuming sulphuric acid 、 五氯化磷 作用下， 反应 7.5h， 生成 (2-bromo-3,4,5,6-tetrafluorobenzene)sulfonyl chloride
  参考文献：
  名称：

  Memory of Chirality Approach to the Enantiodivergent Synthesis of Chiral Benzo[d]sultams

  摘要：

  The "memory of chirality" stereodivergent synthesis of polyfluorobenzo[d]sultams has been developed. The interest of this protocol resides in the possibility of using the chirality of a starting sulfonamide single enantiomer to synthesize the target sultams in both absolute configurations, by using different base systems, under homogeneous conditions.

  DOI：

  10.1021/ol401557v

文献信息

• [EN] STAT INHIBITORY COMPOUNDS AND COMPOSITIONS<br/>[FR] COMPOSÉS ET COMPOSITIONS INHIBITEURS DE STAT
  申请人：JANPIX LTD

  公开号：WO2022051639A1

  公开（公告）日：2022-03-10

  Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for the inhibition of Signal Transducer and Activator of Transcription 5a and 5b (STAT5). Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as, for example, breast cancer, hematological cancer, and pancreatic cancer.

  本文提供了化合物和包含这些化合物的药物组合物，这些化合物对于抑制信号转导和激活转录因子5a和5b（STAT5）非常有用。此外，这些化合物和组合物对于治疗癌症非常有用，例如乳腺癌、血液系统肿瘤和胰腺癌。
• Substituted benzene compounds as antiproliferative and cholesterol lowering action
  申请人：Tularik INC

  公开号：US06284923B1

  公开（公告）日：2001-09-04

  The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I:

  该发明提供了与新型亲电芳香衍生物相关的化合物、组合物和方法，以及它们作为药理活性剂的用途。该组合物在治疗疾病状态，特别是癌症、银屑病、血管再狭窄、感染、动脉硬化和高胆固醇血症方面，作为药理剂使用，或作为这些药理剂开发的引导化合物。该组合物包括一般式I的化合物：
• [EN] ARYLSULFONANILIDE PHOSPHATES<br/>[FR] PHOSPHATES D'ARYLSULFONANILIDE
  申请人：TULARIK INC.

  公开号：WO1999067258A1

  公开（公告）日：1999-12-29

  (EN) The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.(FR) La présente invention concerne des composés, des compositions et des procédés associés à de nouveaux dérivés d'arylsulfonanilide, et leur utilisation comme agents pharmacologiquement actifs. Les compositions de l'invention sont utilisées en particulier dans le traitement d'états maladifs, en particulier le cancer, le psoriasis, la resténose vasculaire, les infections, l'athérosclérose et l'hypercholestérolémie, ou comme chefs de file pour la mise au point d'agents pharmacologiquement actifs.

  该发明提供了与新型芳基磺酰苯胺衍生物相关的化合物、组合物和方法，以及它们作为药理活性剂的用途。这些组合物特别适用于作为药理剂治疗疾病状态，特别是癌症、银屑病、血管再狭窄、感染、动脉粥样硬化和高胆固醇血症，或作为开发此类药理剂的前导化合物。
• Arylsulfonanilide phosphates
  申请人：Tularik, Inc.

  公开号：US20010018430A1

  公开（公告）日：2001-08-30

  The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.

  该发明提供了与新型芳基磺酰苯胺衍生物相关的化合物、组合物和方法，以及它们作为药理活性剂的用途。这些组合物在治疗疾病状态中特别用作药理剂，尤其是癌症、银屑病、血管再狭窄、感染、动脉粥样硬化和高胆固醇血症，或作为开发这些药理剂的引领化合物。
• Benzene compounds as antiproliferative and cholesterol lowering agents
  申请人：——

  公开号：US20020013496A1

  公开（公告）日：2002-01-31

  The invention provides compounds, compositions and methods relating to novel electrophilic aromatic derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents. The compositions include compounds of the general Formula I: 1

  本发明提供了与新型亲电芳香衍生物相关的化合物、组合物和方法，以及它们作为药理活性剂的用途。这些组合物特别适用于治疗疾病状态，特别是癌症、银屑病、血管再狭窄、感染、动脉粥样硬化和高胆固醇血症，或作为这些剂的开发的先导化合物。这些组合物包括通式I的化合物：1。