7-amino-1,3-dimethylpyrimido<4,5-c>pyridazine-4,5(1H,6H)-dione | 67873-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 7-amino-1,3-dimethylpyrimido<4,5-c>pyridazine-4,5(1H,6H)-dione
• 英文别名: 7-amino-1,3-dimethyl-1H,6H-pyrimido[4,5-c]pyridazine-4,5-dione；7-amino-1,3-dimethylpyrimido(4,5-c)pyridazine-4,5-(1H, 6H)-dione；7-amino-1,3-dimethylpyrimido[4,5-c]pyridazine-4,5(1H,6H)-dione；7-amino-1,3-dimethylpyrimido(4,5-c)pyridazine-4,5(1H,6H)-dione；7-amino-1,3-dimethyl-6H-pyrimido[4,5-c]pyridazine-4,5-dione
• CAS: 67873-29-4
• 化学式: C₈H₉N₅O₂
• 分子量: 207.192
• InChiKey: IPKMHRDOJWVZQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  100
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  7-amino-1,3-dimethylpyrimido<4,5-c>pyridazine-4,5(1H,6H)-dione 在 sodium hydroxide 、 锌 作用下， 反应 1.17h， 以90%的产率得到7-amino-2,3-dihydro-1,3-dimethylpyrimido<4,5-c>pyridazine-4,5(1H,6H)-dione
  参考文献：
  名称：

  Pyrimido[4,5-c]pyridazines. 5. Summary of cyclizations with vicinally functionalized reagents and studies of the reductive behavior of the ring system

  摘要：

  DOI：

  10.1021/jo00343a014
• 作为产物：
  描述：

  6-(1-methylhydrazino)isocytosine 以51%的产率得到
  参考文献：
  名称：

  MORRISON R. W. JR.; MALLORY W. R.; STYLES V. L., J. ORG. CHEM., 1978, 43, NO 25, 4844-4849

  摘要：

  DOI：

文献信息

• Substituted pyrimido (4,5-c)pyridazines
  申请人：Burroughs Wellcome Co.

  公开号：US04255427A1

  公开（公告）日：1981-03-10

  This invention provides pyrimido (4,5-c)pyridazines, process for their preparation, veterinary compositions containing them and the preparation of such compositions. These pyrimido (4,5-c)pyridazines are useful in the treatment of coccidiosis.

  这项发明提供了嘧啶并[4,5-c]吡啶嗪，其制备方法，含有它们的兽药组合物以及这种组合物的制备。这些嘧啶并[4,5-c]吡啶嗪在球虫病的治疗中很有用。
• Pyrimido(4,5-c)pyridazines
  申请人：Burroughs Wellcome Co.

  公开号：US04225710A1

  公开（公告）日：1980-09-30

  The present invention provides pyrimido(4,5-c)pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido(4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.

  本发明提供了嘧啶并[4,5-c]吡啶嗪，以及制备它们的方法、含有它们的配方和该配方的制备以及这些化合物在人类治疗中的应用。本发明的这些嘧啶并[4,5-c]吡啶嗪因其作为二氢叶酸和生物合成抑制剂的活性而具有用处。
• 6-(1-Methylhydrazino)isocytosine
  申请人：Burroughs Wellcome Co.

  公开号：US04302587A1

  公开（公告）日：1981-11-24

  The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.

  本发明提供了嘧啶并[4,5-c]吡啶嗪类化合物，以及制备它们的方法、含有它们的配方和制备该配方的方法以及这些化合物在人类疗法中的应用。本发明中的嘧啶并[4,5-c]吡啶嗪类化合物由于其作为二氢叶酸和生物合成抑制剂的活性而具有实用性。
• 2-Amino-4-(substituted hydrazino)-6-imino pyrimidines
  申请人：Burroughs Wellcome Co.

  公开号：US04303789A1

  公开（公告）日：1981-12-01

  The present invention provides pyrimido (4,5-c) pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido (4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.

  本发明提供了嘧啶并(4,5-c)吡啶嗪，以及制备它们的方法、含有它们的配方和制备这种配方以及在人类治疗中使用这种化合物的方法。本发明的这些嘧啶并(4,5-c)吡啶嗪由于其作为二氢叶酸和生物合成抑制剂的活性而有用。
• 2-Amino-4-imino-6-hydrazinopyrimidine
  申请人：Burroughs Wellcome Co.

  公开号：US04303790A1

  公开（公告）日：1981-12-01

  The present invention provides pyrimido(4,5-c)pyridazines, to methods for preparing them, formulations containing them and the preparation of such formulation and the use of such compounds in human therapy. These pyrimido(4,5-c)pyridazines of this invention are useful due to their activity as inhibitors of dihydropteroic and biosynthesis.

  本发明提供了嘧啶并(4,5-c)吡啶嗪，以及制备它们的方法、含有它们的配方和制备这种配方的方法，以及这些化合物在人类治疗中的应用。本发明的这些嘧啶并(4,5-c)吡啶嗪由于其作为二氢叶酸和生物合成抑制剂的活性而有用。