[Benzoyl(propyl)amino] benzoate | 154491-49-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Benzoyl(propyl)amino] benzoate
• CAS: 154491-49-3
• 化学式: C₁₇H₁₇NO₃
• 分子量: 283.327
• InChiKey: JCHQXHWOEILGSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [Benzoyl(propyl)amino] benzoate 在 一水合肼 作用下， 生成 propyl benzohydroxamate
  参考文献：
  名称：

  Synthesis of novel N-(primary) alkylhydroxamic acids

  摘要：

  Synthesis of N-primary alkylhydroxamic acids is described in this paper by benzolyloxylation (benzoyl peroxide) of n-alkylamine and modification of the usual reaction conditions to stabilise the N-alkyl-O-benzoylhydroxylamine as the hydrochloride; this circumvents acyl transfer to amide. N-Acylation of the formed hydroxylamine leads to the formation of N-primary alkyl-N-acyl-O-acylhydroxylamine, which is debenzoylated to hydroxamic acid using hydrazine hydrate.

  DOI：

  10.1016/s0040-4039(00)60153-3
• 作为产物：
  描述：

  过氧化苯甲酰 在 吡啶 、 盐酸 作用下， 反应 0.08h， 生成 [Benzoyl(propyl)amino] benzoate
  参考文献：
  名称：

  Synthesis of novel N-(primary) alkylhydroxamic acids

  摘要：

  Synthesis of N-primary alkylhydroxamic acids is described in this paper by benzolyloxylation (benzoyl peroxide) of n-alkylamine and modification of the usual reaction conditions to stabilise the N-alkyl-O-benzoylhydroxylamine as the hydrochloride; this circumvents acyl transfer to amide. N-Acylation of the formed hydroxylamine leads to the formation of N-primary alkyl-N-acyl-O-acylhydroxylamine, which is debenzoylated to hydroxamic acid using hydrazine hydrate.

  DOI：

  10.1016/s0040-4039(00)60153-3