The Combination of Benzaldehyde and Nickel‐Catalyzed Photoredox C(sp
<sup>3</sup>
)−H Alkylation/Arylation
作者:Lumin Zhang、Xiaojia Si、Yangyang Yang、Marc Zimmer、Sina Witzel、Kohei Sekine、Matthias Rudolph、A. Stephen K. Hashmi
DOI:10.1002/anie.201810526
日期:2019.2.4
Herein we report a highly selective photoredoxC(sp3)−H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3)−H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability