2-(2,4-difluoro-phenyl)-[1,3]dioxolane | 701269-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2,4-difluoro-phenyl)-[1,3]dioxolane
• 英文别名: 2-(2,4-Difluorophenyl)-1,3-dioxolane
• CAS: 701269-35-4
• 化学式: C₉H₈F₂O₂
• mdl: MFCD06209064
• 分子量: 186.158
• InChiKey: SYSBHSDCPBEQLZ-UHFFFAOYSA-N

物化性质

• 沸点：
  205.5±40.0 °C(Predicted)
• 密度：
  1.298±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,4-二氟苯甲醛 、 乙二醇 在 solid acidic polymeric ionic liquid from [SO₃H(CH₂)3VIm]HSO₄ and resorcinol-formaldehyde resin 作用下， 以 环己烷 为溶剂， 反应 1.0h， 以99%的产率得到2-(2,4-difluoro-phenyl)-[1,3]dioxolane
  参考文献：
  名称：

  Synthesis of novel solid acidic ionic liquid polymer and its catalytic activities

  摘要：

  The novel solid acidic ionic liquid polymer has been synthesized through the copolymerization of acidic ionic liquid oligomers and resorcinol-formaldehyde (RF resin). The catalytic activities were investigated through the acetalization. The results showed that the PIL was very efficient for the reactions with the average yield over 99.0%. The procedure was quite simple with just one-step to complete both the reactions. The high hydrophobic BET surface, high catalytic activities and high stability gave the PIL great potential for green chemical processes.

  DOI：

  10.1134/s0023158413060062

文献信息

• Novel mandelic acid derivatives
  申请人：——

  公开号：US20040122057A1

  公开（公告）日：2004-06-24

  The invention is concerned with novel mandelic acid derivatives of formula (I) 1 wherein R 1 to R 10 , X and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor.

  本发明涉及公式（I）1的新型苯甲酸衍生物，其中R1至R10，X和Y如说明书和权利要求中所定义，并且其药学上可接受的盐。这些化合物抑制由因子VIIa和组织因子诱导的凝血因子Xa，IXa和凝血酶的形成。
• Mandelic acid derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US07129238B2

  公开（公告）日：2006-10-31

  The invention is concerned with novel mandelic acid derivatives of formula (I) wherein R1 to R10, X and Y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds inhibit the formation of coagulation factors Xa, IXa and thrombin induced by factor VIIa and tissue factor.

  本发明涉及一种新型的苯乙酸衍生物，其化学式为(I)，其中R1到R10、X和Y的定义如说明书和权利要求中所述，以及其药学上可接受的盐。这些化合物可以抑制因子VIIa和组织因子诱导的凝血因子Xa、IXa和凝血酶的形成。
• 4-[4-[4-[4-[[2-(2,4-Difluorophenyl)-2-(1H-azolylmethyl)-1,3-dioxolan-4-yl]-methoxy]phenyl]-1-piperazinyl]phenyl]triazolones
  申请人：JANSSEN PHARMACEUTICA N.V.

  公开号：EP0283992A2

  公开（公告）日：1988-09-28

  Novel 4-[4-[4-[4-[[2-(2,4-difluorophenyl)-2-(1H-azolylmethyl)-1,3-­dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]triazolones of formula wherein Q is N or CH; R is hydrogen, C₁₋₆alkyl or arylC₁₋₆alkyl; and R¹ is hydrogen, C₁₋₆alkyl or arylC₁₋₆alkyl; wherein aryl is phenyl optionally substituted with up to 3 substituents each independently selected from halo, C₁₋₆alkyl, C₁₋₆alkyloxy and trifluoromethyl, the pharmaceutically acceptable acid addition salts and possible stereochemically isomeric forms thereof, which compounds are anti-microbial agents; pharmaceutical compositions containing such compounds as an active ingredient and methods of preparing said compounds and pharmaceutical compositions.

  新型 4-[4-[4-[4-[[2-(2,4-二氟苯基)-2-(1H-氮唑甲基)-1,3-二氧戊环-4-基]甲氧基]苯基]-1-哌嗪基]苯基]三唑酮，其式为 其中 Q 是 N 或 CH；R 是氢、C₁₋₆ 烷基或 C₁₋₆烷基；R¹ 是氢、C₁₋₆ 烷基或 C₁₋₆烷基；其中芳基是可任选被最多 3 个各自独立选自卤代、C₁₋₆烷基、C₁₋₆烷氧基和三氟甲基的取代基取代的苯基、药学上可接受的酸加成盐及其可能的立体化学异构形式，这些化合物是抗微生物剂；含有此类化合物作为活性成分的药物组合物，以及制备上述化合物和药物组合物的方法。
• Synthesis of a novel ionic liquid with both Lewis and Brønsted acid sites and its catalytic activities
  作者：Xuezheng Liang、Chenze Qi

  DOI：10.1016/j.catcom.2011.01.018

  日期：2011.4

  The novel ionic liquid with both Lewis and Bronsted acid sites has been synthesized and its catalytic activities for acetalization and Michael addition were investigated carefully. The novel ionic liquid was stable to water and could be used in aqueous solution. Furthermore, the molar ratio of the Lewis and Bronsted acid sites could be adjusted according to different reactions. The results showed that the novel ionic liquid was very efficient for the traditional acid-catalyzed reactions with good to excellent yields in short time. (C) 2011 Elsevier B.V. All rights reserved.
• [EN] MANDELIC ACID DERIVATIVES<br/>[FR] DERIVES D'ACIDE MANDELIQUE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004048335A3

  公开（公告）日：2004-08-19