2-phenyl-1,3-di-pyridin-4-yl-propan-2-ol | 3337-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-phenyl-1,3-di-pyridin-4-yl-propan-2-ol
• 英文别名: 2-Phenyl-1,3-di-<(4)-pyridyl>-propan-2-ol；1,3-Bis-pyridyl-(4)-2-phenyl-propanol-(2)；2-Phenyl-1,3-bis-(4)-pyridyl-propanol-(2)；2-Phenyl-1,3-di-(4-pyridyl)-2-propanol；2-Phenyl-1,3-di(4-pyridyl)-2-propanol；2-phenyl-1,3-dipyridin-4-ylpropan-2-ol
• CAS: 3337-46-0
• 化学式: C₁₉H₁₈N₂O
• 分子量: 290.365
• InChiKey: PMIZVHLBVOKZLZ-UHFFFAOYSA-N

物化性质

• 熔点：
  166-168 °C
• 沸点：
  447.9±40.0 °C(Predicted)
• 密度：
  1.185±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2933399090

反应信息

• 作为产物：
  描述：

  4-甲基吡啶 在 lithium diisopropyl amide 、 过氧化苯甲酰 作用下， 生成 1-苯基-2-(4-吡啶)乙酮 、 1,2-双(4-吡啶基)乙烷 、 2-phenyl-1,3-di-pyridin-4-yl-propan-2-ol
  参考文献：
  名称：

  Oxidation products of 5-ethenyl-4-methyl-3-pyridinecarbonitrile and 2- and 4-methylpyridines

  摘要：

  5-乙烯基-4-甲基-3-吡啶腈1的阴离子在二苯甲酰过氧化物的处理下发生氧化偶联反应，生成1,2-双（5'-乙烯基-3'-氰基-4'-吡啶基）-乙烷2。同时也证明了2-甲基吡啶和4-甲基吡啶的阴离子也会发生氧化偶联反应。然而，在后者情况下，偶联反应伴随着对二苯甲酰过氧化物的羰基进行加成反应。加成产物已被鉴定为苯乙酰吡啶和二吡啶甲基苯醇。通过氧汞化-还原过程对1的乙烯基侧链进行了水合，将次级醇氧化成酮。保护形式下的醇和酮都是生物碱合成中潜在有用的中间体。关键词：氧化偶联，2-和4-甲基吡啶，二苯甲酰过氧化物，氧汞化-还原。

  DOI：

  10.1139/v90-090

文献信息

• WANG, JAHANGIR JIAN;SMITH, RICHARD W.;MACLEAN, DAVID B.;HOLLAND, HERBERT +, CAN. J. CHEM., 68,(1990) N, C. 587-591
  作者：WANG, JAHANGIR JIAN、SMITH, RICHARD W.、MACLEAN, DAVID B.、HOLLAND, HERBERT +

  DOI：——

  日期：——
• COMPOSITIONS AND METHODS FOR SELECTIVE POLISHING OF SILICON NITRIDE MATERIALS
  申请人：Cabot Microelectronics Corporation

  公开号：EP2872585B1

  公开（公告）日：2020-09-09
• US9633863B2
  申请人：——

  公开号：US9633863B2

  公开（公告）日：2017-04-25
• [EN] COMPOSITIONS AND METHODS FOR SELECTIVE POLISHING OF SILICON NITRIDE MATERIALS<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR LE POLISSAGE SÉLECTIF DE MATÉRIAUX DE NITRURE DE SILICIUM
  申请人：CABOT MICROELECTRONICS CORP

  公开号：WO2014011678A1

  公开（公告）日：2014-01-16

  The present invention provides an acidic aqueous polishing composition suitable for polishing a silicon nitride-containing substrate in a chemical-mechanical polishing (CMP) process. The composition, at point of use, preferably comprises 0.01 to 2 percent by weight of at least one particulate ceria abrasive, 10 to 1000 ppm of at least one non-polymeric unsaturated nitrogen heterocycle compound, 0 to 1000 ppm of at least one cationic polymer, optionally, 0 to 2000 ppm of at least one polyoxyalkylene polymer, and an aqueous carrier therefor. The cationic polymer preferably is selected from a poly(vinylpyridine) polymer, a quaternary ammonium-substituted acrylate polymer, a quaternary ammonium-substituted methacrylate polymer, or a combination thereof. Methods of polishing substrates and of selectively removing silicon nitride from a substrate in preference to removal of polysilicon using the compositions are also provided.
• Oxidation products of 5-ethenyl-4-methyl-3-pyridinecarbonitrile and 2- and 4-methylpyridines
  作者：Jahangir、Jian Wang、Richard W. Smith、David B. MacLean、Herbert L. Holland

  DOI：10.1139/v90-090

  日期：1990.4.1

  The anion of 5-ethenyl-4-methyl-3-pyridinecarbonitrile 1 undergoes oxidative coupling on treatment with dibenzoyl peroxide affording 1,2-bis-(5′-ethenyl-3′-cyano-4′-pyridyl)-ethane, 2. It is also shown that the anions of 2- and 4-methylpyridine undergo oxidative coupling. In the latter case, however, the coupling reaction is accompanied by addition to the carbonyl group of dibenzoyl peroxide. The addition products have been identified as phenacyl pyridines and dipicolyl phenyl carbinols. The ethenyl side chain of 1 has been hydrated by way of the oxymercuration–reduction process and the secondary alcohol oxidized to a ketone. Both the alcohol and ketone in protected form are potentially useful intermediates in alkaloid synthesis. Keywords: oxidative coupling, 2- and 4-methylpyridines, dibenzoyl peroxide, oxymercuration–reduction.

  5-乙烯基-4-甲基-3-吡啶腈1的阴离子在二苯甲酰过氧化物的处理下发生氧化偶联反应，生成1,2-双（5'-乙烯基-3'-氰基-4'-吡啶基）-乙烷2。同时也证明了2-甲基吡啶和4-甲基吡啶的阴离子也会发生氧化偶联反应。然而，在后者情况下，偶联反应伴随着对二苯甲酰过氧化物的羰基进行加成反应。加成产物已被鉴定为苯乙酰吡啶和二吡啶甲基苯醇。通过氧汞化-还原过程对1的乙烯基侧链进行了水合，将次级醇氧化成酮。保护形式下的醇和酮都是生物碱合成中潜在有用的中间体。关键词：氧化偶联，2-和4-甲基吡啶，二苯甲酰过氧化物，氧汞化-还原。