N-((3S,3aR,6S,6aR)-6-(cyclopropanecarboxamido)-hexahydrofuro[3,2-b]furan-3-yl)-3-phenoxy-benzamide | 1186074-27-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((3S,3aR,6S,6aR)-6-(cyclopropanecarboxamido)-hexahydrofuro[3,2-b]furan-3-yl)-3-phenoxy-benzamide
• 英文别名: N-((3S,3aR,6S,6aR)-6-(Cyclopropanecarboxamido)hexahydrofuro[3,2-b]furan-3-yl)-3-phenoxybenzamide；N-[(3S,3aR,6S,6aR)-3-(cyclopropanecarbonylamino)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl]-3-phenoxybenzamide
• CAS: 1186074-27-0
• 化学式: C₂₃H₂₄N₂O₅
• 分子量: 408.454
• InChiKey: MUFFLYKARMLVJT-UWHLTILDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  85.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-((3S,3aR,6S,6aR)-6-amino-hexahydrofuro[3,2-b]furan-3-yl)-3-phenoxybenzamide 、 环丙甲酸 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 二甲基亚砜 为溶剂， 反应 0.33h， 以85%的产率得到N-((3S,3aR,6S,6aR)-6-(cyclopropanecarboxamido)-hexahydrofuro[3,2-b]furan-3-yl)-3-phenoxy-benzamide
  参考文献：
  名称：

  [EN] ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS
  [FR] DÉRIVÉS D'ISOMANNIDE ET LEUR UTILISATION COMME SUBSTANCES DONNANT DU GOÛT

  摘要：

  公开号：

  WO2011002871A3

文献信息

• ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS
  申请人：Tachdjian Catherine

  公开号：US20120183660A1

  公开（公告）日：2012-07-19

  The present invention provides isomannide derivatives having structural formula (I) as shown below and certain subgenera or species thereof, as flavoring agents or tastants, flavor or taste modifiers, and/or flavor/taste enhancers, particularly, savory (“umami”) flavoring agent or tastant, savory taste modifiers, and/or savory flavor enhancers, for ingestible compositions. The present invention also provides methods of preparing isomannide derivatives having the structural formula (II) shown below and certain subgenera or species thereof.

  本发明提供了具有如下所示的结构式(I)及其某些亚属或种类的异曼尼糖衍生物，作为风味剂或味觉剂，风味或味觉调节剂，以及/或风味/味觉增强剂，特别是咸味（"鲜味"）风味剂或味觉剂，咸味调节剂和/或咸味风味增强剂，用于可食用组合物。本发明还提供了制备具有如下所示的结构式(II)及其某些亚属或种类的异曼尼糖衍生物的方法。
• ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS
  申请人：TACHDJIAN Catherine

  公开号：US20130295261A1

  公开（公告）日：2013-11-07

  The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory (“umami”) taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,

  本发明提供以下式子及其特定亚属或种类的异山梨酯衍生物，作为味道或口感调节剂，特别是让食品、饮料和其他食品组合物具有鲜美（鲜味）口感的调节剂、风味剂和风味增强剂。
• US8420145B2
  申请人：——

  公开号：US8420145B2

  公开（公告）日：2013-04-16
• [EN] ISOSORBIDE DERIVATIVES AND THEIR USE AS FLAVOR MODIFIERS, TASTANTS, AND TASTE ENHANCERS<br/>[FR] DÉRIVÉS D'ISOSORBIDE ET LEUR UTILISATION EN TANT QUE MODIFICATEURS DE PARFUM, AGENTS DONNANT DU GOÛT ET EXHAUSTEURS DE GOÛT
  申请人：SENOMYX INC

  公开号：WO2009111447A2

  公开（公告）日：2009-09-11

  The present invention provides isosorbide derivatives having the formula shown below and certain subgenera or species thereof, as flavor or taste modifiers, particularly, savory ('umami') taste modifiers, savory flavoring agents and savory flavor enhancers in foods, beverages, and other comestible compositions,
• [EN] ISOMANNIDE DERIVATIVES AND THEIR USE AS TASTANTS<br/>[FR] DÉRIVÉS D’ISOMANNIDE ET LEUR UTILISATION COMME SUBSTANCES DONNANT DU GOÛT
  申请人：SENOMYX INC

  公开号：WO2011002871A2

  公开（公告）日：2011-01-06

  The present invention provides isomannide derivatives having structural formula (I) as shown below and certain subgenera or species thereof, as flavoring agents or tastants, flavor or taste modifiers, and/or flavor/taste enhancers, particularly, savory ("umami") flavoring agent or tastant, savory taste modifiers, and/or savory flavor enhancers, for ingestible compositions. The present invention also provides methods of preparing isomannide derivatives having the structural formula (II) shown below and certain subgenera or species thereof. Formulae (I) and (II).