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N,N-diethoxy aniline | 99703-55-6

中文名称
——
中文别名
——
英文名称
N,N-diethoxy aniline
英文别名
N,N-diethoxyaniline
N,N-diethoxy aniline化学式
CAS
99703-55-6
化学式
C10H15NO2
mdl
——
分子量
181.235
InChiKey
AKUBZUGGSGGUEF-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    215.5±23.0 °C(Predicted)
  • 密度:
    1.046±0.06 g/cm3(Predicted)

计算性质

  • 辛醇/水分配系数(LogP):
    2.9
  • 重原子数:
    13
  • 可旋转键数:
    5
  • 环数:
    1.0
  • sp3杂化的碳原子比例:
    0.4
  • 拓扑面积:
    21.7
  • 氢给体数:
    0
  • 氢受体数:
    3

反应信息

  • 作为反应物:
    描述:
    N,N-diethoxy aniline三氯氧磷 作用下, 以 N,N-二甲基甲酰胺 为溶剂, 反应 5.0h, 以35%的产率得到4-[双-(2-氯乙基)氨基]苯甲醛
    参考文献:
    名称:
    A BODIPY-based sensor for Hg2+ in living cells
    摘要:
    A BODIPY-based probe has been investigated for fast response to Hg2+ with high sensitivity and selectivity in living cells. This response is attributed to intramolecular charge transfer (ICT) mechanisms. The detection limit is lower than the upper limit (10 nM) that the United States Environmental Protection Agency (EPA) had mandated for Hg2+ in drinking water. (C) 2013 Elsevier Ltd. All rights reserved.
    DOI:
    10.1016/j.tet.2013.06.025
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文献信息

  • [EN] PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS<br/>[FR] PYRAZOLO[4,3-D]PYRIMIDINES UTILES EN TANT QU'INHIBITEURS DE KINASES
    申请人:ORIGENIS GMBH
    公开号:WO2012143144A1
    公开(公告)日:2012-10-26
    The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.
    本发明涉及一种能够抑制一个或多个激酶,特别是SYK(脾酪氨酸激酶)、LRRK2(富含亮氨酸重复的激酶2)和/或MYLK(肌球蛋白轻链激酶)或其突变体的化合物的新颖化合物(I)的公式。这些化合物在治疗各种疾病中发挥作用。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和与激素相关的疾病。
  • [EN] HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES EN TANT QU'INHIBITEURS DE KINASES
    申请人:ORIGENIS GMBH
    公开号:WO2012143143A1
    公开(公告)日:2012-10-26
    The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.
    本发明涉及一种能够抑制一个或多个激酶,特别是SYK(脾酪氨酸激酶)、LRRK2(富含亮氨酸重复激酶2)和/或MYLK(肌球蛋白轻链激酶)或其突变体的化合物的新颖化合物(I)的公式。这些化合物在治疗各种疾病中发挥作用。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和与激素相关的疾病。
  • [EN] METHOD FOR PRODUCING 1-HEXENE<br/>[FR] PROCÉDÉ DE PRODUCTION D'1-HEXÈNE
    申请人:SUMITOMO CHEMICAL CO
    公开号:WO2012133937A1
    公开(公告)日:2012-10-04
    Disclosed is a method for producing 1-hexene that is capable of reducing the amount of by-product polymers when 1-hexene is produced through the trimerization reaction of ethylene. The method for producing 1-hexene comprises the following steps 1 and 2: step 1: the step of preparing a catalytic component by bringing a transition metal complex represented by any one of formulae (1-1) to (1-3) into contact with a specific organic aluminum compound in the absence of ethylene; and step 2: the step of trimerizing ethylene in the presence of a catalyst obtainable by bringing the catalytic component obtained in step 1 into contact with a specific boron compound.
    公开了一种生产1-己烯的方法,该方法能够在通过乙烯的三聚反应生产1-己烯时减少副产物聚合物的数量。生产1-己烯的方法包括以下步骤1和2:步骤1:通过将由式(1-1)到(1-3)中的任一表示的过渡金属配合物与特定有机铝化合物接触而制备催化组分,在没有乙烯的情况下;步骤2:在将在步骤1中获得的催化组分与特定硼化合物接触而获得的催化剂存在下,三聚乙烯。
  • [EN] METHOD FOR PRODUCING THE TRANSITION METAL ION COMPLEX, CATALYST FOR TRIMERIZATION, AND METHOD FOR PRODUCING 1-HEXENE<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN COMPLEXE ION MÉTAL DE TRANSITION, CATALYSEUR DE TRIMÉRISATION, ET PROCÉDÉ DE PRODUCTION DE 1-HEXÈNE
    申请人:SUMITOMO CHEMICAL CO
    公开号:WO2012133929A1
    公开(公告)日:2012-10-04
    An object of the present invention is to provide a silicon-bridged Cp-Ar transition metal complex that serves as a catalytic component capable of efficiently and highly selectively producing 1-hexene through the trimerization reaction of ethylene. The present invention provides a transition metal ion complex represented by any of formulae (1-1) to (1-3), etc.: wherein M represents a transition metal atom of Group 4 of the Periodic Table of the Elements; A represents a counter anion; R1, R2, R3, R4, R5, R6, R7, R8, R9, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, X1 and X2 each independently represent a hydrogen atom or the like; R10 and R11 each independently represent a hydrogen atom or the like.
    本发明的一个目的是提供一种硅桥联的Cp-Ar过渡金属配合物,作为一种催化组分,能够通过乙烯三聚反应高效且高选择性地产生1-己烯。本发明提供了一种过渡金属离子配合物,其表示为任一化学式(1-1)至(1-3)等:其中M表示元素周期表第4族的过渡金属原子;A表示反离子;R1、R2、R3、R4、R5、R6、R7、R8、R9、R12、R13、R14、R15、R16、R17、R18、R19、R20、R21、X1和X2每个独立地表示氢原子或类似物;R10和R11每个独立地表示氢原子或类似物。
  • [EN] METHOD FOR PRODUCING THE TRANSITION METAL COMPLEX, CATALYST FOR TRIMERIZATION, METHOD FOR PRODUCING 1-HEXENE, METHOD FOR PRODUCING THE SUBSTITUTED CYCLOPENTADIENE COMPOUND (2)<br/>[FR] PROCÉDÉ DE PRODUCTION D'UN COMPLEXE MÉTAL DE TRANSITION, CATALYSEUR DE TRIMÉRISATION, PROCÉDÉ DE PRODUCTION DE 1-HEXÈNE, PROCÉDÉ DE PRODUCTION D'UN COMPOSÉ DE CYCLOPENTADIÈNE SUBSTITUÉ (2)
    申请人:SUMITOMO CHEMICAL CO
    公开号:WO2012133925A1
    公开(公告)日:2012-10-04
    An object of the present invention is to provide a silicon-bridged Cp-Ar transition metal complex that serves as a catalytic component capable of efficiently and highly selectively producing 1-hexene through the trimerization reaction of ethylene. A transition metal complex represented by formula (1), etc. wherein M represents a transition metal atom of Group 4 of the Periodic Table of the Elements; X1, X2, X3, R1, R2, R3, R4, R5, R6, R7, R8, and R9 each independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 20 carbon atoms which may have a halogen atom, an alkoxy group having 1 to 20 carbon atoms which may have a halogen atom, an aryl group having 6 to 20 carbon atoms which may have a halogen atom, an aryloxy group having 6 to 20 carbon atoms which may have a halogen atom, an aralkyl group having 7 to 20 carbon atoms which may have a halogen atom, an aralkyloxy group having 7 to 20 carbon atoms which may have a halogen atom, etc.
    本发明的目的是提供一种硅桥联的Cp-Ar过渡金属配合物,作为催化组分,能够通过乙烯三聚反应高效、高选择性地产生1-己烯。其中,M代表元素周期表第4族的过渡金属原子;X1、X2、X3、R1、R2、R3、R4、R5、R6、R7、R8和R9各自独立地代表氢原子、卤素原子、具有1至20个碳原子的烷基基团,可能带有卤素原子,具有1至20个碳原子的烷氧基团,可能带有卤素原子,具有6至20个碳原子的芳基基团,可能带有卤素原子,具有6至20个碳原子的芳氧基团,可能带有卤素原子,具有7至20个碳原子的芳基烷基基团,可能带有卤素原子,具有7至20个碳原子的芳基烷氧基团,可能带有卤素原子等。
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