3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one | 307335-47-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
• 英文别名: 3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
• CAS: 307335-47-3
• 化学式: C₂₀H₂₂ClN₃O
• 分子量: 355.867
• InChiKey: NKJVFWPJNBYTCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  35.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碘乙烷 、 3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 5.0h， 以78%的产率得到3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-1-ethyl-3,4-dihydro-1H-quinolin-2-one
  参考文献：
  名称：

  Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives

  摘要：

  3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (delta-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D-2/D-4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (gamma-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones (E-lactams) were also prepared and examined. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00421-2
• 作为产物：
  描述：

  1-(4-氯苄基)哌嗪 在 palladium on activated charcoal 盐酸 、 sodium hydroxide 、 氢气 、 sodium ethanolate 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 、 乙酸乙酯 、 乙腈 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 79.0h， 生成 3-[4-(4-Chloro-benzyl)-piperazin-1-yl]-3,4-dihydro-1H-quinolin-2-one
  参考文献：
  名称：

  Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives

  摘要：

  3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (delta-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D-2/D-4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (gamma-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones (E-lactams) were also prepared and examined. (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00421-2

文献信息

• Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives
  作者：He Zhao、Andrew Thurkauf、Julia Braun、Robin Brodbeck、Andrzej Kieltyka

  DOI：10.1016/s0960-894x(00)00421-2

  日期：2000.9

  3-Piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives (delta-lactams) were designed, synthesized, and identified as a new series of mixed dopamine D-2/D-4 receptor antagonists. To further the structure-activity relationship (SAR) study, 3-piperazinylindolin-2-ones (gamma-lactams) and 3-piperazinyl-3H,4H,5H-benzo[f]azepin-2-ones (E-lactams) were also prepared and examined. (C) 2000 Elsevier Science Ltd. All rights reserved.