N-chloro-2-methylaniline | 57218-02-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-chloro-2-methylaniline
• 英文别名: N-chloro-ortho-toluidine；Benzenamine, N-chloro-2-methyl-
• CAS: 57218-02-7
• 化学式: C₇H₈ClN
• 分子量: 141.6
• InChiKey: SHLTXWFNRJQZTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Alpha4beta1 and alpha4beta7 integrin inhibitors
  申请人：——

  公开号：US20020091142A1

  公开（公告）日：2002-07-11

  Compounds of the formula I 1 as defined and their pharmaceutically acceptable salts are inhibitors of &agr; 4 &bgr; 1 and/or &agr; 4 &bgr; 7 integrins, and are useful in inhibiting cell adhesion and in the therapeutic or prophylactic treatment of transplant rejection and inflammatory and autoimmune diseases.

  公式I1所定义的化合物及其药用盐是α4β1和/或α4β7整合素的抑制剂，并且在抑制细胞粘附以及治疗或预防移植排斥和炎症性和自身免疫疾病方面是有用的。
• [EN] CYSTATHIONINE-Y-GAMMA-LYASE (CSE) INHIBITORS<br/>[FR] INHIBITEURS DE LA CYSTATHIONINE-Y-GAMMA-LYASE (CSE)
  申请人：SOVA PHARMACEUTICALS INC

  公开号：WO2014018569A1

  公开（公告）日：2014-01-30

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ- lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

  本文描述了抑制半胱氨酸-γ-裂解酶（CSE）的化合物和含有这些化合物的药物组合物。本文还描述了使用这些CSE抑制剂的方法，单独或与其他化合物结合，用于治疗需要CSE抑制的疾病或症状。
• Separation of amine from a phenolic compound
  申请人：Renner A. Carl

  公开号：US20050080294A1

  公开（公告）日：2005-04-14

  A process comprises contacting a product mixture with a base, optionally in the presence of a polyhydric alcohol, to produce a base-treated mixture and distilling the base-treated mixture in which the product mixture comprises an aromatic amine and a phenolic compound.

  一个过程包括将产品混合物与碱接触，可选地在多元醇的存在下，以产生经碱处理的混合物，并蒸馏经碱处理的混合物，其中产品混合物包括芳香胺和酚化合物。
• N-alkyl-N-(Aminophenylsulfonyl)-aminoalkylphosphonic acids and salts
  申请人：CROMPTON & KNOWLES CORPORATION

  公开号：EP0385010A1

  公开（公告）日：1990-09-05

  This invention relates to novel N-alkyl-N-(amino-phenylsulfonyl)-aminoalkylphosphonic acids and to processes for their preparation. These compounds are useful as intermediates, especially for the manufacture of dyes containing phosphonic acid groups in their structure. Such dyes are reactive with cellulosic fibers and fabrics in the presence of carbodiimides at elevated temperatures.

  本发明涉及新型N-烷基-N-(氨基苯磺酰基)-氨基烷基膦酸以及它们的制备方法。这些化合物可用作中间体，尤其适用于制造含有膦酸基团的染料。这些染料在存在卡波二亚胺的情况下，在高温下与纤维素纤维和织物反应。
• CYSTATHIONINE-GAMMA-LYASE (CSE) INHIBITORS
  申请人：SOVA PHARMACEUTICALS, INC.

  公开号：US20150175561A1

  公开（公告）日：2015-06-25

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

  本文描述了一些抑制半胱氨酸-γ-裂解酶（CSE）的化合物和含有这些化合物的药物组合物。本文还描述了使用这些CSE抑制剂的方法，单独或与其他化合物结合，用于治疗需要CSE抑制的疾病或病症。