chloro-5-nitroaniline | 57218-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: chloro-5-nitroaniline
• 英文别名: Benzenamine, N-chloro-3-nitro-；N-chloro-3-nitroaniline
• CAS: 57218-03-8
• 化学式: C₆H₅ClN₂O₂
• 分子量: 172.571
• InChiKey: ZRQSYIAOCGKOJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] PYRAZOLO [4, 3-D] PYRIMIDINES USEFUL AS KINASE INHIBITORS<br/>[FR] PYRAZOLO[4,3-D]PYRIMIDINES UTILES EN TANT QU'INHIBITEURS DE KINASES
  申请人：ORIGENIS GMBH

  公开号：WO2012143144A1

  公开（公告）日：2012-10-26

  The present invention relates to novel compounds of formula (I) that are capable of inhibiting one or more kinases, especially SYK (Spleen Tyrosine Kinase), LRRK2 (Leucine-rich repeat kinase 2) and/or MYLK (Myosin light chain kinase) or mutants thereof. The compounds find applications in the treatment of a variety of diseases. These diseases include autoimmune diseases, inflammatory diseases, bone diseases, metabolic diseases, neurological and neurodegenerative diseases, cancer, cardiovascular diseases, allergies, asthma, alzheimer's disease, parkinson's disease, skin disorders, eye diseases, infectious diseases and hormone-related diseases.

  本发明涉及一种能够抑制一个或多个激酶，特别是SYK（脾酪氨酸激酶）、LRRK2（富含亮氨酸重复的激酶2）和/或MYLK（肌球蛋白轻链激酶）或其突变体的化合物的新颖化合物（I）的公式。这些化合物在治疗各种疾病中发挥作用。这些疾病包括自身免疫疾病、炎症性疾病、骨疾病、代谢性疾病、神经和神经退行性疾病、癌症、心血管疾病、过敏、哮喘、阿尔茨海默病、帕金森病、皮肤疾病、眼部疾病、传染病和与激素相关的疾病。
• DIAMINOPYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF
  申请人：LEE Hyun-Joo

  公开号：US20150274700A2

  公开（公告）日：2015-10-01

  The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-HT 4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal diseases, such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, or diabetic gastric atony.

  本发明提供了一种二氨基嘧啶衍生物或其药学上可接受的盐，其制备方法，包括该衍生物的制药组合物以及其用途。该二氨基嘧啶衍生物或其药学上可接受的盐作为5-HT4受体激动剂，因此可用于预防或治疗胃肠运动功能障碍，如胃食管反流病（GERD）、便秘、肠易激综合征（IBS）、消化不良、术后肠麻痹、胃排空延迟、胃轻瘫、肠假性梗阻、药物诱导的肠道传输延迟或糖尿病性胃弛缓等胃肠疾病。
• Benzothiazolones, their production and use as herbicides
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0258773A2

  公开（公告）日：1988-03-09

  A compound of the formula: wherein R¹ is a C₁-C₅ alkyl group, a C₃-C₄ alkenyl group, a C₃-C₄ alkynyl group or a C₁-C₂ alkoxy(C₁-C₂)alkyl group, R² is a t-butyl group or a 1-methylcyclopropyl group and X is a fluorine atom or a chlorine atom, which is useful as a herbicide.

  式中 R¹ 为 C₁-C₅ 烷基、C₃-C₄ 烯基、C₃-C₄ 炔基或 C₁-C₂ 烷氧基（C₁-C₂）烷基，R² 为叔丁基或 1-甲基环丙基，X 为氟原子或氯原子的化合物，可用作除草剂。
• PYRAZOLO [4, 3-D]PYRIMIDINES USEFUL AS KINASE INHIBITORS
  申请人：Origenis GmbH

  公开号：EP2699579A1

  公开（公告）日：2014-02-26
• US3992392A
  申请人：——

  公开号：US3992392A

  公开（公告）日：1976-11-16