2-(2-Methoxypropyl)-phenol | 70482-66-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-Methoxypropyl)-phenol
• 英文别名: o-(2-Methoxypropyl)-phenol；2-(2-Methoxypropyl)phenol
• CAS: 70482-66-5
• 化学式: C₁₀H₁₄O₂
• 分子量: 166.22
• InChiKey: YKPOGZFRULQBPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  甲醇 、 2-烯丙基酚 在 Carreira’s cobalt catalyst 、 1,1,3,3-tetramethyldisiloxane 、 1-fluoro-2,4,6-trimethylpyridin-1-ium tetrafluoroborate 作用下， 反应 17.0h， 以78%的产率得到2-(2-Methoxypropyl)-phenol
  参考文献：
  名称：

  Hydroalkoxylation of Unactivated Olefins with Carbon Radicals and Carbocation Species as Key Intermediates

  摘要：

  A unique Markovnikov hydroalkoxylation of unactivated olefins with a cobalt complex, silane, and N-fluoropyridinium salt is reported. Further optimization of reaction conditions yielded high functional group tolerance and versatility of alcoholic solvent employed, including methanol, i-propanol, and t-butanol. Use of trifluorotoluene as a solvent made the use of alcohol in stoichiometric amount possible. Mechanistic insight into this novel catalytic system is also discussed. Experimental results suggest that catalysis involves both carbon radical and carbocation intermediates.

  DOI：

  10.1021/ja405219f

文献信息

• Mitochondria protecting agents for treating mitochondria associated diseases
  申请人：——

  公开号：US20020068750A1

  公开（公告）日：2002-06-06

  The present invention relates generally to mitochondria protecting agents for treating diseases in which mitochondrial dysfunction leads to tissue degeneration and, more specifically, to compounds, compositions and methods related to the same. The methods of this invention involve administration of a pharmaceutically effective amount of a mitochondria protecting agent to a warm-blooded animal in need thereof, and composition of this invention contain a mitochondrial protecting agent in combination with a pharmaceutically acceptable carrier or diluent. Mitochondrial associated diseases which may be treated by the present invention include (but are not limited to) Alzheimer's Disease, diabetes mellitus, Parkinson's Disease, neuronal and cardiac ischemia, Huntington's disease and stroke.

  本发明通常涉及用于治疗线粒体功能失调导致组织退化的疾病的线粒体保护剂，更具体地涉及与此相关的化合物、组合物和方法。本发明的方法涉及向需要此类保护剂的温血动物投予药学有效量的线粒体保护剂，并且本发明的组合物包含与药学可接受的载体或稀释剂结合的线粒体保护剂。本发明可以治疗的线粒体相关疾病包括（但不限于）阿尔茨海默病、糖尿病、帕金森病、神经和心脏缺血、亨廷顿病和中风。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, And Composition For Transfer And Storage Of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Shinohata Masaaki

  公开号：US20110133121A1

  公开（公告）日：2011-06-09

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明涉及一种从有机胺、碳酸衍生物和含有一种或多种羟基化合物中制得的N-取代氨基甲酸酯的制备方法，其中使用一种含有冷凝器的脲类生产反应容器反应有机胺、碳酸衍生物和羟基化合物，将含有羟基化合物的气体、来自碳酸衍生物衍生的含有羰基基团的化合物、以及在反应中形成的氨气体引入到脲类生产反应容器中的冷凝器中，使羟基化合物和含有羰基基团的化合物冷凝，其中在冷凝的羟基化合物中所含有的羟基化合物与冷凝的含有羰基基团的化合物中所含有的羰基基团的化合物的比例为1或更多，而且在从冷凝器中回收的氨气体中所含有的羰基基团（—C(═O)—）数与氨分子数的比例为1或更少。
• N-Substituted Carbamic Acid Ester Production Method, Isocyanate Production Method Using Such N-Substituted Carbamic Acid Ester, and Composition for Transfer and Storage of N-Substituted Carbamic Acid Ester Comprising N-Substituted Carbamic Acid Ester and Aromatic Hydroxy Compound
  申请人：Asahi Kasei Chemicals Corporation

  公开号：US20140194650A1

  公开（公告）日：2014-07-10

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (—C(═O)—) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种从有机胺、碳酸酯衍生物和含有一种或多种羟基化合物中制备N-取代的氨基甲酸酯的方法，其中利用一种尿素生产反应容器反应有机胺、碳酸酯衍生物和羟基化合物，该反应容器配有冷凝器，将含有羟基化合物的气体、由碳酸酯衍生物产生的含有羰基基团的化合物以及在反应中生成的氨引入到尿素生产反应容器中的冷凝器中，将羟基化合物和含有羰基基团的碳酸酯衍生物冷凝，其中在冷凝的羟基化合物中所含的羟基化合物的化学计量比与所冷凝的含有羰基基团的化合物的化学计量比为1或更多，而且所含有羰基基团的化合物中所含的羰基基团（-C(═O)-）的数量与从冷凝器中回收的氨分子数量的比率为1或更小。
• METHOD FOR PRODUCING N-SUBSTITUTED CARBAMIC ACID ESTER
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：EP3153499A1

  公开（公告）日：2017-04-12

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (-C(=O)-) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种用有机胺、碳酸衍生物和含有一种或多种羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺、碳酸衍生物和羟基组合物在一个装有冷凝器的氨基甲酸乙酯生产反应釜中反应、使用配备有冷凝器的聚氨酯生产反应容器对碳酸衍生物和羟基组合物进行反应，将含有羟基组合物、从碳酸衍生物衍生出的具有羰基的化合物以及在反应中作为副产物形成的氨的气体引入聚氨酯生产反应容器中的冷凝器、缩合羟基组合物和具有碳酸衍生物衍生的羰基的化合物，其中缩合羟基组合物中所含的羟基化合物与具有碳酸衍生物衍生的羰基的缩合化合物的化学计量比为 1 或以上、且具有碳酸衍生物衍生的羰基的化合物中所含的羰基数（-C(=O)-）与从冷凝器中作为气体回收的氨中所含的氨分子数之比为 1 或更少。
• METHOD FOR PRODUCING ISOCYANATE USING N-SUBSTITUTED CARBAMIC ACID ESTER, AND COMPOSITION FOR TRANSFERRING AND STORING N-SUBSTITUTED CARBAMIC ACID ESTER CONTAINING N-SUBSTITUTED CARBAMIC ACID ESTER AND AROMATIC HYDROXY COMPOUND
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：EP3153500A1

  公开（公告）日：2017-04-12

  The present invention is a method for producing an N-substituted carbamic acid ester derived from an organic amine from an organic amine, a carbonic acid derivative and a hydroxy composition containing one or more types of hydroxy compounds, wherein the organic amine, the carbonic acid derivative and the hydroxy composition are reacted using a urethane production reaction vessel provided with a condenser, a gas containing the hydroxy composition, the compound having the carbonyl group derived from the carbonic acid derivative, and an ammonia formed as a by-product in the reaction, is introduced into the condenser provided in the urethane production reaction vessel, and the hydroxy composition and the compound having the carbonyl group derived from the carbonic acid derivative are condensed, and wherein a stoichiometric ratio of a hydroxy compound contained in the condensed hydroxy composition to the condensed compound having the carbonyl group derived from the carbonic acid derivative is 1 or more, and a ratio of number of carbonyl groups (-C(=O)-) contained in the compound having the carbonyl group derived from the carbonic acid derivative and number of ammonia molecules contained in the ammonia recovered as a gas from the condenser is 1 or less.

  本发明是一种用有机胺、碳酸衍生物和含有一种或多种羟基化合物的羟基组合物生产由有机胺衍生的N-取代氨基甲酸酯的方法，其中有机胺、碳酸衍生物和羟基组合物在一个装有冷凝器的氨基甲酸乙酯生产反应釜中反应、使用配备有冷凝器的聚氨酯生产反应容器对碳酸衍生物和羟基组合物进行反应，将含有羟基组合物、从碳酸衍生物衍生出的具有羰基的化合物以及在反应中作为副产物形成的氨的气体引入聚氨酯生产反应容器中的冷凝器、缩合羟基组合物和具有碳酸衍生物衍生的羰基的化合物，其中缩合羟基组合物中所含的羟基化合物与具有碳酸衍生物衍生的羰基的缩合化合物的化学计量比为 1 或以上、且具有碳酸衍生物衍生的羰基的化合物中所含的羰基数（-C(=O)-）与从冷凝器中作为气体回收的氨中所含的氨分子数之比为 1 或更少。