phenyl (2-methoxyethyl)carbamate | 65935-05-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl (2-methoxyethyl)carbamate
• 英文别名: Phenyl 2-methoxyethylcarbamate；phenyl N-(2-methoxyethyl)carbamate
• CAS: 65935-05-9
• 化学式: C₁₀H₁₃NO₃
• mdl: MFCD02965706
• 分子量: 195.218
• InChiKey: UPMVOZWBRAWZKF-UHFFFAOYSA-N

物化性质

• 沸点：
  276.7±32.0 °C(Predicted)
• 密度：
  1.113±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl (2-methoxyethyl)carbamate 在 一水合肼 作用下， 反应 12.0h， 以84%的产率得到4-(2-methoxyethyl)semicarbazide
  参考文献：
  名称：

  Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives

  摘要：

  Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(97)00011-6
• 作为产物：
  描述：

  N-(2-methoxyethyl)-1H-imidazole-1-carboxamide 、 苯酚 以 水 为溶剂， 反应 2.0h， 生成 phenyl (2-methoxyethyl)carbamate
  参考文献：
  名称：

  Unprecedented “In Water” Imidazole Carbonylation: Paradigm Shift for Preparation of Urea and Carbamate

  摘要：

  The first "In Water" Imidazolecarbonylation of amine is described. A one pot reaction of carbonylimidazolide in water with a nucleophile provides an efficient and general method for the preparation of urea, carbamates and thiocarbamates. Use of an anhydrous solvent and an inert atmosphere could be avoided. Product precipitate out from the reaction mixture and can be obtained In high purity by filtration, resulting in a simple and scalable method.

  DOI：

  10.1021/ol301009d

文献信息

• 苯基丙酰胺类衍生物、其制备方法及其在医药 上的应用
  申请人：江苏恒瑞医药股份有限公司

  公开号：CN107098876B

  公开（公告）日：2021-04-06

  本发明涉及苯基丙酰胺类衍生物、其制备方法及其在医药上的应用。特别地，本发明涉及通式(I)所示的苯基丙酰胺类衍生物、其制备方法及含有该衍生物的药物组合物，以及其作为κ阿片样物质受体(KOR受体)激动剂的用途，和其在制备治疗和/或预防疼痛和疼痛相关疾病的药物中的用途。其中通式(I)的各取代基与说明书中的定义相同。。
• [EN] DIHYDROPYRIMIDINONE DERIVATIVE AND PHARMACEUTICAL USE THEREOF<br/>[FR] DÉRIVÉ DE DIHYDROPYRIMIDINONE ET SON UTILISATION PHARMACEUTIQUE
  申请人：DAINIPPON SUMITOMO PHARMA CO

  公开号：WO2012002502A1

  公开（公告）日：2012-01-05

  　本発明は、下記一般式（Ｉ）で表される化合物、又はその生理的に許容される塩（式中、Ｒ0は、－Ｃ（＝Ｏ）ＮＲa－、－Ｓ（＝Ｏ）２ＮＲa－、－Ｃ（＝Ｏ）Ｏ－、単結合等を表し、Ｒ1は、水素原子、アルキル、アルケン、ヘテロ原子を含んでいてもよい３～６員の飽和若しくは４～６員の不飽和の脂肪族環基、ヘテロ原子を含んでいてもよい５～６員の芳香族環基等を表し、Ｒ2は、水素原子、アルキル等を表し、Ｒ3およびＲ4は、それぞれ独立して、水素原子、アルキル等を表し、Ｌは、５～６員の芳香族環基または－Ｓ（＝Ｏ）q－を表し、Ａｒ1およびＡｒ2は、それぞれ独立して、ヘテロ原子を含んでいてもよい５～６員の１箇所以上置換された芳香族環基を表す。）、および該化合物などを有効成分として含有する、エラスターゼが関与する各種炎症疾患の治療または予防剤を提供する。
• Unprecedented “In Water” Imidazole Carbonylation: Paradigm Shift for Preparation of Urea and Carbamate
  作者：Kamlesh J. Padiya、Sandip Gavade、Bhavana Kardile、Manojkumar Tiwari、Swapnil Bajare、Madhav Mane、Vivek Gaware、Shaji Varghese、Dipak Harel、Suresh Kurhade

  DOI：10.1021/ol301009d

  日期：2012.6.1

  The first "In Water" Imidazolecarbonylation of amine is described. A one pot reaction of carbonylimidazolide in water with a nucleophile provides an efficient and general method for the preparation of urea, carbamates and thiocarbamates. Use of an anhydrous solvent and an inert atmosphere could be avoided. Product precipitate out from the reaction mixture and can be obtained In high purity by filtration, resulting in a simple and scalable method.
• Synthesis and anti-trypanosomal activity of novel 5-nitro-2-furaldehyde and 5-nitrothiophene-2-carboxaldehyde semicarbazone derivatives
  作者：Hugo Cerecetto、Rossanna Di Maio、Gerardo Ibarruri、Gustavo Seoane、Ana Denicola、Gonzalo Peluffo、Celia Quijano、Margot Paulino

  DOI：10.1016/s0014-827x(97)00011-6

  日期：1998.2

  Several novel semicarbazones derivatives were prepared from 5-nitro-2-furaldehyde or 5-nitrothiophene-2-carboxaldehyde, and tested in vitro as potential anti trypanosomal agents. The compounds were prepared in good to excellent yields in 2-3 steps from readily available starting materials. Some derivatives were found to be active against Trypanosoma cruzi with an activity similar to that of Nifurtimox. (C) 1998 Elsevier Science S.A. All rights reserved.