3,4-Diphenyl-benzoesaeure | 98804-30-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-Diphenyl-benzoesaeure
• 英文别名: 3,4-Diphenylbenzoic acid
• CAS: 98804-30-9
• 化学式: C₁₉H₁₄O₂
• 分子量: 274.319
• InChiKey: OTMUTAGYDMOGFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(3-吡啶)丁基胺 、 3,4-Diphenyl-benzoesaeure 在 二苯基膦叠氮化物 、 三乙胺 作用下， 以 乙酸乙酯 、 N,N-二甲基甲酰胺 、 苯 为溶剂， 生成 3,4-Diphenyl-N-[4-(3-pyridinyl)butyl]benzamide
  参考文献：
  名称：

  Substituted n-[(pyridyl)alkyl]aryl-carboxamide

  摘要：

  该发明涉及以下式的化合物##STR1##其中*B为##STR2##Y为O或S，*A为*--(CH.sub.2).sub.n --(X).sub.m --(CH.sub.2).sub.r --，n或r独立地为0到3的整数，m为0到1的整数，但当m为1时，n必须至少为1，X为O或S，R.sub.1和R.sub.4独立地为氢、较低的烷基、羟基或较低的烷氧基，但当*B不是##STR3##时，R.sub.1和R.sub.4中至少一个，以及R.sub.6和R.sub.7中的一个必须为氢，R.sub.2和R.sub.3独立地为氢、较低的烷基、环烷基、卤素、硝基、较低的烷氧基、较低的烯基、较低的炔基或芳基，R.sub.5和R.sub.6独立地为氢或较低的烷基，R.sub.7为氢、较低的烷基、环烷基或芳基，Het为含有一或两个异原子（从氮、氧和硫中选择）的单环5-或6-成员杂芳基或含有一个或两个异原子的双环杂芳基，该基团可以被较低的烷基、卤素或芳基取代，星号表示连接点，当R.sub.6和R.sub.7不同时，它们的对映异构体和外消旋混合物，以及其药学上可接受的酸盐。式I的化合物表现为血小板活化因子（PAF）拮抗剂的活性，因此，它们可用作预防和治疗血管疾病、肺部疾病、皮肤病、移植排斥、免疫紊乱和炎症症状的药物。

  公开号：

  US04916145A1
• 作为产物：
  描述：

  2.3-diphenyl-(4arH.9acH)-1.4.4a.9a-tetrahydro-anthraquinone 在 氢氧化钾 作用下， 生成 3,4-Diphenyl-benzoesaeure
  参考文献：
  名称：

  Allen; Eliot; Bell, Canadian Journal of Research, Section B: Chemical Sciences, 1939, vol. 17, p. 75,87

  摘要：

  DOI：

文献信息

• Substituted n-[(pyridyl)alkyl]aryl-carboxamide
  申请人：Hoffmann-La Roche Inc.

  公开号：US04916145A1

  公开（公告）日：1990-04-10

  The invention relates to compounds of the formula ##STR1## wherein *B is ##STR2## Y is O or S, *A is *--(CH.sub.2).sub.n --(X).sub.m --(CH.sub.2).sub.r --, n or r, independently, are integers from 0 to 3, m is an integer from 0 to 1, provided that when m is 1, then n must be at least 1, X is O or S, R.sub.1 and R.sub.4, independently, are hydrogen, lower alkyl, hydroxy or lower alkoxy, provided that when *B is other than ##STR3## at least one of R.sub.1 and R.sub.4, and one of R.sub.6 and R.sub.7 must be hydrogen, R.sub.2 and R.sub.3 are independently hydrogen, lower alkyl, cycloalkyl, halogen, nitro, lower alkoxy, lower alkenyl, lower alkynyl or aryl, R.sub.5 and R.sub.6, independently are hydrogen or lower alkyl, R.sub.7 is hydrogen, lower alkyl, cycloalkyl or aryl, Het is a monocyclic 5- or 6-membered hetero aromatic or a bicyclic heteroaromatic radical containing one or two hetero atoms selected from nitrogen oxygen and sulfur, which radical may be substituted by lower alkyl, halogen or aryl, and the asterisk denotes the point of attachment, and when R.sub.6 and R.sub.7 are different, their enantiomers and racemic mixtures thereof, and pharmaceutical acceptable acid addition salts thereof. The compounds of formula I exhibit activity as Platelet Activating Factor (PAF) antagonists and are, therefore, useful as agents for the prevention and treatment of vascular diseases, pulmonary diseases, dermatological disorders, transplant rejection, immunological disorders and inflammatory conditions.

  该发明涉及以下式的化合物##STR1##其中*B为##STR2##Y为O或S，*A为*--(CH.sub.2).sub.n --(X).sub.m --(CH.sub.2).sub.r --，n或r独立地为0到3的整数，m为0到1的整数，但当m为1时，n必须至少为1，X为O或S，R.sub.1和R.sub.4独立地为氢、较低的烷基、羟基或较低的烷氧基，但当*B不是##STR3##时，R.sub.1和R.sub.4中至少一个，以及R.sub.6和R.sub.7中的一个必须为氢，R.sub.2和R.sub.3独立地为氢、较低的烷基、环烷基、卤素、硝基、较低的烷氧基、较低的烯基、较低的炔基或芳基，R.sub.5和R.sub.6独立地为氢或较低的烷基，R.sub.7为氢、较低的烷基、环烷基或芳基，Het为含有一或两个异原子（从氮、氧和硫中选择）的单环5-或6-成员杂芳基或含有一个或两个异原子的双环杂芳基，该基团可以被较低的烷基、卤素或芳基取代，星号表示连接点，当R.sub.6和R.sub.7不同时，它们的对映异构体和外消旋混合物，以及其药学上可接受的酸盐。式I的化合物表现为血小板活化因子（PAF）拮抗剂的活性，因此，它们可用作预防和治疗血管疾病、肺部疾病、皮肤病、移植排斥、免疫紊乱和炎症症状的药物。
• AROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHONATE (S1P) RECEPTOR ACTIVITY
  申请人：Takeuchi Janet A.

  公开号：US20110281822A1

  公开（公告）日：2011-11-17

  Novel aromatic compounds which are useful as sphingosine-1-phosphate modulators and useful for treating a wide variety of disorders associated with modulation of sphingosine-1-phosphate receptors.

  一种新颖的芳香化合物，可用作神经酰胺-1-磷酸酯调节剂，对治疗与神经酰胺-1-磷酸酯受体调节相关的各种疾病有益。
• LIQUID CRYSTAL COMPOUND CONTAINING A DIFLUORMETHOXY BRIDGE AND APPLICATION THEREOF
  申请人：BEIJING BAYI SPACE LCD TECHNOLOGY CO., LTD

  公开号：US20180148398A1

  公开（公告）日：2018-05-31

  The present invention relates to a liquid crystal compound having a structure as shown by formula I, wherein R is selected from H and alkyl or alkoxy containing 1-12 carbon atoms in which one or more H are unsubstituted or substituted with halogens; A 1 , A 2 and A 3 are each independently selected from: a single bond, 1,4-cyclohexylene, 1,4-phenylene, wherein hydrogen in 1,4-phenylene may be each independently substituted with one or more halogens; and Z 1 and Z 2 are each independently selected from a single bond or —(CH 2 ) 2 —. The compound of the invention has the characteristics of low rotational viscosity, large dielectric anisotropy, good mutual solubility and stability. The driving voltage of a device can be remarkably reduced after the compound is added to a composition. Thus, the compound of the invention has prosperous applications in LCD industry.

  本发明涉及一种具有如公式I所示结构的液晶化合物，其中R从H和烷基或含有1-12个碳原子的烷氧基中选择，其中一个或多个H未取代或用卤素取代；A1、A2和A3分别独立选择自：单键，1,4-环己烯基，1,4-苯基，其中1,4-苯基中的氢原子可以各自独立地被一个或多个卤素取代；Z1和Z2各自独立选择自单键或—(CH2)2—。该发明的化合物具有低转动黏度、大介电各向异性、良好的互溶性和稳定性的特点。在将该化合物添加到组合物后，设备的驱动电压可以显著降低。因此，该发明的化合物在液晶显示行业有着广泛的应用前景。
• Liquid crystal compound containing a difluormethoxy bridge and application thereof
  申请人：BEIJING BAYI SPACE LCD TECHNOLOGY CO., LTD.

  公开号：US10584086B2

  公开（公告）日：2020-03-10

  The present invention relates to a liquid crystal compound having a structure as shown by formula I, wherein R is selected from H and alkyl or alkoxy containing 1-12 carbon atoms in which one or more H are unsubstituted or substituted with halogens; A1, A2 and A3 are each independently selected from: a single bond, 1,4-cyclohexylene, 1,4-phenylene, wherein hydrogen in 1,4-phenylene may be each independently substituted with one or more halogens; and Z1 and Z2 are each independently selected from a single bond or —(CH2)2—. The compound of the invention has the characteristics of low rotational viscosity, large dielectric anisotropy, good mutual solubility and stability. The driving voltage of a device can be remarkably reduced after the compound is added to a composition. Thus, the compound of the invention has prosperous applications in LCD industry.

  本发明涉及一种液晶化合物，其结构如式 I 所示，其中 R 选自 H 和含有 1-12 个碳原子的烷基或烷氧基，其中一个或多个 H 未被取代或被卤素取代；A1、A2 和 A3 各自独立地选自：单键、1,4-环己烯、1,4-亚苯基，其中 1,4- 亚苯基中的氢可各自独立地被一个或多个卤素取代；Z1 和 Z2 各自独立地选自单键或-(CH2)2-。本发明的化合物具有旋转粘度低、介电各向异性大、互溶性和稳定性好的特点。将本发明化合物添加到组合物中后，可显著降低设备的驱动电压。因此，本发明的化合物在液晶显示行业有着广阔的应用前景。
• Liquid crystal composition and its application
  申请人：Jiang Tianmeng

  公开号：US10655064B2

  公开（公告）日：2020-05-19

  The present invention provides a novel liquid crystal material composition comprising one or more compound, in order to achieve the properties of low viscosity, high resistivity, good low-temperature mutual solubility, fast response, excellent transmission, and which can be used for a variety of fast response display modes. Since the working temperature of a LCD material is subjected to the temperature range of individual LC molecules, information can only be displayed in a specific temperature range of the specific liquid crystal macro-alignment phase. At low temperature, the viscosity of liquid crystal increases exponentially, which in turn substantially reduces the response speed and overall performances of the display system. The liquid crystal composition according to the present invention overcomes these problems with balanced chemical composition by achieving low viscosity, good low-temperature performance and excellent transmission in a wide range of LCD applications including TN, IPS or FFS displays, thus improving display performance.

  本发明提供了一种由一种或多种化合物组成的新型液晶材料组合物，以实现低粘度、高电阻率、良好的低温互溶性、快速响应、优异的透射率等特性，可用于多种快速响应显示模式。由于液晶材料的工作温度受制于单个液晶分子的温度范围，因此只能在特定液晶宏配位相的特定温度范围内显示信息。在低温条件下，液晶的粘度会成倍增加，从而大大降低显示系统的响应速度和整体性能。本发明的液晶组合物通过平衡化学成分克服了这些问题，在包括 TN、IPS 或 FFS 显示器在内的广泛液晶应用中实现了低粘度、良好的低温性能和出色的传输性能，从而提高了显示性能。