3-(2,6-二氯苯基)-5-甲基异噁唑-4-氨基甲酰肼 | 263255-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 3-(2,6-二氯苯基)-5-甲基异噁唑-4-氨基甲酰肼
• 英文名称: 3-(2,6-dichlorophenyl)-5-methylisoxazole-4-carbohydrazide
• 英文别名: 3-(2,6-dichlorophenyl)-5-methyl-1,2-oxazole-4-carbohydrazide
• CAS: 263255-98-7
• 化学式: C₁₁H₉Cl₂N₃O₂
• 分子量: 286.117
• InChiKey: IVYIDBDPOPYCGE-UHFFFAOYSA-N

物化性质

• 密度：
  1.441±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  81.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3-双邻氯苯基-5-甲基-4-异恶唑酰氯 在 hydrazine hydrate 、 potassium carbonate 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.25h， 生成 3-(2,6-二氯苯基)-5-甲基异噁唑-4-氨基甲酰肼
  参考文献：
  名称：

  N-氨基-1,8-萘二甲酰亚胺是用于选择性合成单-N-取代肼和酰肼的再生保护基团

  摘要：

  N-氨基-1,8-萘二甲酰亚胺用作保护基团和试剂，用于选择性合成各种单-N-取代的肼和酰肼。在所有这些反应中，保护试剂N-氨基-1,8-萘二甲酰亚胺很容易通过肼解以良好的产率再生。所有这些转化都显示出良好的官能团耐受性，可用于大规模的 CN 交叉偶联反应。

  DOI：

  10.1002/chem.202102593

文献信息

• Small-molecule modulators of hepatocyte growth factor / scatter factor activities
  申请人：——

  公开号：US20030216459A1

  公开（公告）日：2003-11-20

  The invention is directed to small organic molecules having the ability to mimic or agonize hepatocyte growth factor/scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.

  本发明涉及具有模拟或激动肝细胞生长因子/散射因子（HGF/SF）活性，或抑制或拮抗 HGF/SF 活性的有机小分子，前者可用于促进组织或器官的血管化，以促进伤口或组织愈合，或增加或恢复缺血组织（如心肌梗塞后的心脏）的血流量。抑制细胞生长或增殖有利于治疗炎症性疾病（如关节炎和皮肤病）和增殖障碍性疾病（如癌症）等。
• MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF
  申请人：North Shore-Long Island Jewish Health System

  公开号：EP1355921A2

  公开（公告）日：2003-10-29
• [EN] MODULATORS OF CELLULAR PROLIFERATION AND ANGIOGENESIS, METHODS FOR USE AND IDENTIFICATION THEREOF<br/>[FR] MODULATEURS DE LA PROLIFERATION CELLULAIRE ET ANGIOGENESE, LEURS PROCEDES D'UTILISATION ET D'IDENTIFICATION
  申请人：LONG ISLAND JEWISH RES INST

  公开号：WO2002002593A2

  公开（公告）日：2002-01-10

  The invention is directed to small organic molecules and peptides having the ability to mimic or agonize hepatocyte growth factor/ scatter factor (HGF/SF) activity, or inhibit or antagonize HGF/SF activity, the former useful for promoting, for example, vascularization of tissues or organs for promoting wound or tissue healing, or augmenting or restoring blood flow to ischemic tissues such as the heart following myocardial infarction. Inhibition of cellular growth or proliferation is beneficial in the treatment, for example, of inflammatory diseases such as inflammatory joint and skin diseases, and dysproliferative diseases such as cancer.
• <i>N</i> ‐Amino‐1,8‐Naphthalimide is a Regenerated Protecting Group for Selective Synthesis of Mono‐N‐Substituted Hydrazines and Hydrazides
  作者：Mesram Manoj Kumar、Parikibanda Venkataramana、Parikibanda Yadagiri Swamy、Yadaiah Chityala

  DOI：10.1002/chem.202102593

  日期：2021.12.15

  N-Amino-1,8-naphthalimide was used as a protecting group and a reagent to selective synthesis of various mono-N-substituted hydrazines and hydrazides. In all these reactions, the protecting reagent N-amino-1,8-naphthalimide was easily regenerated in good yields by the hydrazinolysis. All these transformations showed good functional-group tolerance and can be used for large scale C−N cross-coupling

  N-氨基-1,8-萘二甲酰亚胺用作保护基团和试剂，用于选择性合成各种单-N-取代的肼和酰肼。在所有这些反应中，保护试剂N-氨基-1,8-萘二甲酰亚胺很容易通过肼解以良好的产率再生。所有这些转化都显示出良好的官能团耐受性，可用于大规模的 CN 交叉偶联反应。