1,4-dihydro-pyridine-3,5-dicarboxylic acid | 3078-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,4-dihydro-pyridine-3,5-dicarboxylic acid
• 英文别名: 1,4-dihydropyridine-3,5-dicarboxylic acid diester；3,5-Pyridinedicarboxylic acid, 1,4-dihydro-；1,4-dihydropyridine-3,5-dicarboxylic acid
• CAS: 3078-68-0
• 化学式: C₇H₇NO₄
• 分子量: 169.137
• InChiKey: COLPLFZHPXIFCQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  86.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  3,5-吡啶二甲酸 、 氰基硼氢化钠 以77%的产率得到
  参考文献：
  名称：

  BOOKER E.; EISNER U., J. CHEM. SOC. PERKIN TRANS. , 1975, PART 1, NO 10, 929-931

  摘要：

  DOI：
• 作为试剂：
  描述：

  在 1,4-dihydro-pyridine-3,5-dicarboxylic acid 作用下， 以 甲苯 为溶剂， 反应 48.0h， 以93%的产率得到N-(2-nitro-1-p-tolylethyl)acetamide
  参考文献：
  名称：

  用于β-酰氨基硝基烯烃不对称转移氢化的聚（乙二醇）负载的多氢键催化剂

  摘要：

  制备了一种新型聚乙二醇负载的多氢键催化剂，并研究了其作为β-酰氨基硝基烯烃不对称转移加氢促进剂的能力。PEG 负载的多氢键催化剂表现出高对映选择性方式（ee 高达 95%），它很容易通过用乙醚选择性沉淀和从反应混合物中过滤去除，聚合物结合的催化剂已回收高达 6 次无化学和立体化学效率的损失。图形摘要

  DOI：

  10.1007/s10562-019-02755-1

文献信息

• Chemical compounds having ion channel blocking activity for the treatment of immune dysfunction
  申请人：——

  公开号：US20020119989A1

  公开（公告）日：2002-08-29

  The present invention relates to chemical compounds having inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca), and the use of such compounds for the treatment or alleviation of diseases or conditions relating to immune dysfunction. Moreover, the invention relates to a method of screening a chemical compound for inhibitory activity on an intermediate conductance Ca 2+ activated potassium channel (IK Ca).

  本发明涉及具有对中间电导性Ca2+激活钾通道（IK Ca）具有抑制活性的化合物，以及利用这种化合物治疗或缓解与免疫功能紊乱相关的疾病或症状。此外，本发明涉及一种筛选化合物对中间电导性Ca2+激活钾通道（IK Ca）具有抑制活性的方法。
• Polymorph Compositions, Methods of Making, and Uses Thereof
  申请人：Macdonald R. Loch

  公开号：US20130302431A1

  公开（公告）日：2013-11-14

  The described invention provides a biodegradable, biocompatible delivery system of flowable sustained release microparticulate composition of a substantially pure crystalline form of a bioactive agent such as, for example, nimodipine, a process of preparing a therapeutic form of a substantially pure crystalline form of the bioactive agent and a method for treating an interruption of a cerebral artery in a subarachnoid space at risk of interruption caused by brain injury in a mammal, which reduces signs or symptoms of at least one delayed complication associated with brain injury.

  所述发明提供了一种可生物降解、生物相容的流动持续释放微粒组合物的输送系统，其包含一种基本纯的晶体形式的生物活性剂，例如尼莫地平，以及一种制备基本纯的晶体形式生物活性剂的治疗形式的过程，以及一种治疗哺乳动物脑损伤引起的潜在中断的蛛网膜下腔脑动脉中断的方法，该方法减少与脑损伤相关的至少一种延迟并发症的症状或体征。
• 1,4-dihydropyridine-3,5-dicarboxylate Derivatives And Preparation And Use Thereof
  申请人：Zhang Hui

  公开号：US20140045896A1

  公开（公告）日：2014-02-13

  The present invention relates to a 1,4-dihydropyridine-3,5-dicarboxylate compound of general compound (I), a process for preparing the same, a use thereof for the manufacture of a medicament for treating and/or preventing kidney injury, cardiovascular diseases and/or endocrine diseases, as well as a pharmaceutical composition and a pharmaceutical formulation containing said compounds, wherein the definitions of R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , m, n 1 , n 2 , p and q are the same as those defined in the description.

  本发明涉及一种一般化合物(I)的1,4-二氢吡啶-3,5-二羧酸酯化合物，以及其制备方法，用于制备治疗和/或预防肾脏损伤、心血管疾病和/或内分泌疾病的药物的用途，以及含有所述化合物的药物组合物和制剂，其中R1、R2、R3、R4、R5、R6、R7、R8、m、n1、n2、p和q的定义与描述中定义的相同。
• 1,4-Dihydropyridine derivatives
  申请人：Korea Research Institute of Chemical Technology

  公开号：EP0324626A1

  公开（公告）日：1989-07-19

  1,4-dihydropyridine derivatives represented by the formula: wherein R¹ and R², different from the other, is selected from the group consisting of lower alkyl, lower alkenyl, lower alkoxyalkyl or aminoaryl(lower)alkyl having carbon atoms of 1 to 6, which may be substituted or unsubstituted by a lower alkyl having carbon atoms of 1 to 4, wherein at least one of R¹ and R² is a lower alkenyl having carbon atoms of 3 to 6 whose 1- or 2- position is substituted by a lower alkyl having carbon atoms of 1 to 4; and R³ is a nitro group in ortho-, meta- or para-position of the phenyl. The compounds are useful as vasodilators and in the treatment of hypertension.

  1,4-二氢吡啶衍生物的化学式表示为：其中R¹和R²，不同于另一个，选自由1至6个碳原子的较低烷基、较低烯基、较低烷氧基烷基或氨基芳基(较低)烷基组成的基团，该基团可能被1至4个碳原子的较低烷基取代或未取代，其中R¹和R²中至少一个是碳原子为3至6的较低烯基，其1-或2-位置被1至4个碳原子的较低烷基取代；以及R³是苯环的邻位、间位或对位的硝基基团。这些化合物可用作扩血管剂，并用于治疗高血压。
• SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO[4,5]DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF
  申请人：Deshpande Mukund Vinayak

  公开号：US20120225877A1

  公开（公告）日：2012-09-06

  This invention relates provides novel substituted 1,4-dioxa-8-azaspiro[4,5]decane of general formula (1), wherein R1 is selected from phenethyl, 4,6-dimethoxypyrimidin-2-yl and (2-chloro-5-thiazolyl)methyl and R2 is selected from the group consisting of hydroxy, 4-bromo-2-chlorophenoxy, morpholin-4-yl, (2-chloro-5-thiazolyl)methyloxy, benzyloxy, phenylsulfanyl, benzotriazol-1-yl and 5-chloro-2-fluoroanilino. The present invention also relates to a process for the preparation of novel substituted 1,4-dioxa-8-azaspiro[4,5]decanes of general formula (1). The novel substituted 1,4-dioxa-8-azaspiro[4,5]decane of general formula (1) has fungicidal activity.

  这项发明涉及提供一种新型的通式（1）的取代1,4-二氧杂-8-氮杂螺[4,5]癸烷，其中R1选自苯乙基、4,6-二甲氧基嘧啶-2-基和（2-氯-5-噻唑基）甲基，R2选自羟基、4-溴-2-氯苯氧基、吗啉-4-基、（2-氯-5-噻唑基）甲氧基、苄氧基、苯基硫基、苯并三氮唑-1-基和5-氯-2-氟苯胺。本发明还涉及一种制备新型取代1,4-二氧杂-8-氮杂螺[4,5]癸烷的方法。通式（1）的新型取代1,4-二氧杂-8-氮杂螺[4,5]癸烷具有杀真菌活性。