3-(2-吡啶基)-1-丙烯-2-醇 | 98491-41-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 3-(2-吡啶基)-1-丙烯-2-醇
• 中文别名: 2-吡啶乙醇,a-亚甲基-
• 英文名称: 2-Pyridineethanol,alpha-methylene-
• 英文别名: 3-pyridin-2-ylprop-1-en-2-ol
• CAS: 98491-41-9
• 化学式: C₈H₉NO
• 分子量: 135.166
• InChiKey: AFOUBUPLBCPSFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  33.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(2-吡啶基)-1-丙烯-2-醇 、 copper diacetate 以 乙醇 为溶剂， 生成 Cu(II)-bis{1-(2-pyridinyl)-2-propanonato-N,O}
  参考文献：
  名称：

  Valle, G., Zeitschrift fur Kristallographie

  摘要：

  DOI：

文献信息

• Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes
  申请人：——

  公开号：US20030073728A1

  公开（公告）日：2003-04-17

  A combination therapy of at least one FBPase inhibitor and at least one other antidiabetic agent is disclosed.

  揭示了至少一种FBPase抑制剂和至少一种其他抗糖尿病药物的联合治疗。
• Novel bisamidate phosphonate prodrugs
  申请人：METABASIS THERAPEUTICS, INC.

  公开号：US20020173490A1

  公开（公告）日：2002-11-21

  Novel bisamidate phosphonate prodrugs of FBPase inhibitors of the Formula IA: 1 and their use in the treatment of diabetes and other conditions associated with elevated blood glucose.

  新颖的双酰胺磷酸酯前药，用于治疗糖尿病和其他与血糖升高相关的疾病的Formula IA:1中的FBPase抑制剂及其用途。
• Antioxidant amines based on n-(4aniliophenyl) amides Antioxidant amines based on n-(4-anilinophenyl) Amides
  申请人：——

  公开号：US20030030033A1

  公开（公告）日：2003-02-13

  A composition of matter is disclosed wherein the composition comprises an N-aromatic substituted acid amide compound selected from the group consisting of compounds of formula (I) wherein A and B are independently selected alkylene groups; R 1 is selected form the group consisting of hydrogen, alkyl alkylether, or ester; R 2 is hydrogen if R 1 is hydrogen; R 2 is an alkyl primary amine if R 1 is alkyl, alkylether, or ester, R 3 and R 4 are independently selected from the group consisting of hydrogen and alkyl; R 5 is a sterically hindered phenolic group of formula (II) or formula (III) wherein X is CH 2 , S, NH, or O; and m, n, and p are independently selected integers equal to 0 or 1. These compositions may be used as such or they may be bound to a polymer backbone via a linking moiety. In either case, they are useful as antioxidants, particularly in lubricating oil compositions.

  揭示了一种物质组成，其中该组成物包括选择自公式（I）化合物的N-芳基取代酸酰胺化合物，其中A和B是独立选择的烷基基团；R1从由氢，烷基烷醚或酯组成的群中选择；如果R1是氢，则R2是氢；如果R1是烷基，烷基醚或酯，则R2是烷基一级胺，R3和R4是独立选择的氢和烷基的群；R5是公式（II）或公式（III）的立体位阻酚基团，其中X为CH2，S，NH或O；m，n和p是独立选择的等于0或1的整数。这些组成物可以直接使用，或者它们可以通过连接基团与聚合物骨架结合。在任何情况下，它们都可作为抗氧化剂使用，特别是在润滑油组成物中。
• Combination of FBPase inhibitors and insulin sensitizers for the treatment of diabetes
  申请人：——

  公开号：US20040167178A1

  公开（公告）日：2004-08-26

  Pharmaceutical compositions containing an FBPase inhibitor and an insulin sensitizer are provided as well as methods for treating diabetes and diseases responding to increased glycemic control, an improvement in insulin sensitivity, a reduction in insulin levels, or an enhancement of insulin secretion.

  提供了含有FBPase抑制剂和胰岛素敏感剂的制药组合物，以及治疗糖尿病和对增加血糖控制、改善胰岛素敏感性、降低胰岛素水平或增强胰岛素分泌有反应的疾病的方法。
• Novel heteroaromatic inhibitors of fructose 1,6-bisphosphatase
  申请人：——

  公开号：US20040058892A1

  公开（公告）日：2004-03-25

  Novel FBPase inhibitors of the formula I and X 1 are useful in the treatment of diabetes and other conditions associated with elevated blood glucose.

  化合物I和X1的新型FBPase抑制剂对于治疗糖尿病和其他与血糖升高有关的疾病是有用的。