1,4-benzoxathiin | 255-42-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 1,4-benzoxathiin
• 英文别名: benzo[1,4]oxathiine；Benz[1,4]oxathiin；Benzo-1,4-oxathiadien；Benzo-1,4-oxathiin；Benzo[b][1,4]oxathiine；1,4-benzoxathiine
• CAS: 255-42-5
• 化学式: C₈H₆OS
• mdl: MFCD18450495
• 分子量: 150.201
• InChiKey: IBJUOHSSKYWIIN-UHFFFAOYSA-N

物化性质

• 沸点：
  63-65 °C(Press: 0.7 Torr)
• 密度：
  1.250±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,4-benzoxathiin 在 二硫化碳 、 溴 作用下， 生成 2,3-dibromo-2,3-dihydro-benz[1,4]oxathiin
  参考文献：
  名称：

  Heterocyclic Vinyl Ethers. IV. Benzo-1,4-oxathiadiene and Benzo-1,4-dithiadiene^1,2

  摘要：

  DOI：

  10.1021/ja01633a041
• 作为产物：
  描述：

  2-Acetoxy-2,3-dihydro-benz[1,4]oxathiin 生成 1,4-benzoxathiin
  参考文献：
  名称：

  Heterocyclic Vinyl Ethers. IV. Benzo-1,4-oxathiadiene and Benzo-1,4-dithiadiene^1,2

  摘要：

  DOI：

  10.1021/ja01633a041

文献信息

• Herbicides
  申请人：RHONE-POULENC AGRICULTURE LTD.

  公开号：EP0918056A1

  公开（公告）日：1999-05-26

  The invention relates to 4-aroylisoxazole derivatives of formula (Ia) or to 2-cyano-1,3-dione derivatives of formula (Ib):    wherein R, R1, R2, X, Y and Z are as defined in the description, and to their use as herbicides.

  本发明涉及公式（Ia）的4-芳酰基异噁唑衍生物或公式（Ib）的2-氰基-1,3-二酮衍生物：其中R、R1、R2、X、Y和Z如描述中所定义，并且它们的用途为除草剂。
• Substituted guanidine derivatives
  申请人：——

  公开号：US20030018056A1

  公开（公告）日：2003-01-23

  A compound represented by the following formula: 1 wherein R is a substituted or unsubstituted benzene ring, a fused polycyclic hydrocarbon ring which is substituted or unsubstituted, a monocyclic heterocyclic ring which is substituted or unsubstituted, a polycyclic heterocyclic ring which is substituted or unsubstituted, A and E are independently a single bond, a lower alkylene group or the like, G is a single bond, an oxygen atom or the like, and Y is a —SO 3 H group or the like, a prodrug of said compound, or a pharmaceutically acceptable salt of said compound or prodrug is useful as a therapeutic or prophylactic agent for diseases caused by the acceleration of the sodium/proton exchange transport system.

  以下化合物的化学式：1其中R是取代或未取代的苯环，取代或未取代的融合多环碳氢环，取代或未取代的单环杂环环，取代或未取代的多环杂环环，A和E分别是单键，低碳烷基或类似物，G是单键，氧原子或类似物，Y是—SO3H基团或类似物，该化合物的前药，或该化合物或前药的药学可接受的盐对于由于钠/质子交换转运系统加速引起的疾病是有用的治疗或预防剂。
• [EN] MODIFIED CARBON MATERIALS FOR USE IN ENERGY STORAGE DEVICES<br/>[FR] MATÉRIAUX DE CARBONE MODIFIÉ DESTINÉES À DES DISPOSITIF DE STOCKAGE D'ÉNERGIE
  申请人：SOLVAY

  公开号：WO2015092022A1

  公开（公告）日：2015-06-25

  Electrodes for energy storage devices comprising modified carbon materials with organic redox moieties covalently attached to the carbon surface.

  电能储存设备用电极，包括修饰的碳材料，有机氧化还原物质共价连接到碳表面。
• Benzamide derivatives
  申请人：Imazaki Naonori

  公开号：US20050182040A1

  公开（公告）日：2005-08-18

  A compound represented by formula (1): wherein X is a single bond or a substituted or unsubstituted lower alkylene group; Z is a saturated or unsaturated monocyclic hydrocarbon ring group or the like; and each of R 1 , R 2 , R 3 and R 4 , which may be the same or different, is a hydrogen atom, a halogen atom, a nitro group, a cyano group, a carboxyl group, a substituted or unsubstituted alkyl group, or the like, a prodrug of said compound, or a pharmaceutically acceptable salt of said compound or prodrug has inhibitory effect on Rho kinase and hence is useful for treating diseases which are such that morbidity due to them is expected to be improved by inhibition of Rho kinase and secondary effects such as inhibition of the Na + /H + exchange transport system caused by the Rho kinase inhibition, for example, hypertension.

  一种由公式（1）表示的化合物：其中X是单键或取代或未取代的较低烷基链；Z是饱和或不饱和的单环烃基环或类似物；而每个R1、R2、R3和R4，可以相同也可以不同，是氢原子、卤素原子、硝基、氰基、羧基、取代或未取代的烷基或类似物，该化合物的前药，或该化合物或前药的药学上可接受的盐具有抑制Rho激酶的作用，因此可用于治疗因抑制Rho激酶而预计疾病的发病率得到改善的疾病，例如高血压，并且由于Rho激酶抑制所引起的Na+/H+交换转运系统的抑制等二次效应。
• Condensed ring compound and use thereof
  申请人：Takeuchi Jun

  公开号：US20060194797A1

  公开（公告）日：2006-08-31

  The present invention relates to a compound of formula (I) (wherein all symbols have the same meanings as described hereinbefore). The compound antagonizes cysLT 2 and therefore, it is useful as an agent for the prevention and/or treatment of respiratory diseases such as bronchial asthma, bronchial asthma, chronic obstructive pulmonary disease, pneumonectasia, chronic bronchitis, pneumonia (e.g. interstitial pneumonitis etc.), severe acute respiratory syndrome (SARS), acute respiratory distress syndrome (ARDS), allergic rhinitis, sinusitis (e.g. acute sinusitis, chronic sinusitis, etc.), and the like, or as an expectorant or antitussives.

  本发明涉及一种化合物，其化学式为(I)（其中所有符号的含义如前所述）。该化合物对cysLT2具有拮抗作用，因此，它可作为预防和/或治疗呼吸系统疾病（如支气管哮喘、慢性阻塞性肺疾病、肺气肿、慢性支气管炎、肺炎（如间质性肺炎等）、严重急性呼吸综合征（SARS）、急性呼吸窘迫综合征（ARDS）、过敏性鼻炎、鼻窦炎（如急性鼻窦炎、慢性鼻窦炎等）等，或作为祛痰药或止咳药物使用。