[Pt(ppbipy)Cl] | 246258-49-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: [Pt(ppbipy)Cl]
• 英文别名: [Pt(4,6-diphenyl-2,2'-bipyridine)Cl]；4,6-diphenyl-2,2'-bipyridyl platinum chloride；4,6-diphenyl-2,2'-bipyridine platinum(II) chloride；chloro(4,6-diphenyl-2,2'-bipyridine(-1H))platinum(II)；4,6-diphenyl-2,2'-bipyridyl platinum(II) chloride；[PtCl(4-phenyl-6-phenyl-2,2'-bipyridine(-1H))]；[Pt(Cl)(4,6-diphenyl-2,2'-bipyridine)(1-)]；(4,6-diphenyl-2,2'-bipyridine(1-))PtCl；dphbpyPtCl；Chloroplatinum(1+);4-phenyl-2-phenyl-6-pyridin-2-ylpyridine
• CAS: 246258-49-1
• 化学式: C₂₂H₁₅ClN₂Pt
• 分子量: 537.907
• InChiKey: NSJJEULIISKGKH-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.96
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [Pt(ppbipy)Cl] 、 4-乙炔联苯 在 copper(l) iodide diisopropylethylamine 作用下， 以 二氯甲烷 为溶剂， 生成 [4,6-diphenyl-2,2'-bipyridyl]Pt(CCC6H4C6H5)
  参考文献：
  名称：

  不同乙酰基配体的环金属化4,6-二苯基-2,2'-联吡啶基铂（II）配合物的光物理性质和非线性吸收

  摘要：

  系统地研究了一系列带有不同σ-炔基辅助配体（1a - 1k）的4,6-二苯基-2,2'-联吡啶基铂（II）配合物的光物理性质。所有配合物表现出强1个π，π*在UV区吸收带; 可见区中宽阔的无结构电荷转移带，当对位取代基在苯乙炔配体上的供电子能力增加时，该转移带系统地发生红移。在室温下，所有络合物在溶液中都是发光的。当在电荷转移吸收带处激发时，络合物显示长寿命的橙色发射（λmax：555-601 nm），这归因于三重态金属到配体的电荷转移/配体内的电荷转移发射（3 MLCT / 3 ILCT）。这些络合物中的大多数在近红外区可见光中均表现出广泛的三重态瞬态差异吸收，其寿命可与通过3 MLCT / 3 ILCT发射的衰减测得的寿命相比。使用纳秒激光脉冲在532 nm处证明了这些络合物的反向饱和吸收（RSA）。RSA的程度如下这种趋势：1K ≈ 1A > 1C > 1F ≈ 1I > 1H ≈ 1B

  DOI：

  10.1021/jp107348h
• 作为产物：
  描述：

  苯甲醛 在 ammonium acetate 、 sodium hydroxide 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 反应 128.0h， 生成 [Pt(ppbipy)Cl]
  参考文献：
  名称：

  含喹唑啉类配体的Pt配合物及其制备方法和 应用

  摘要：

  本发明涉及一种含喹唑啉类配体的Pt配合物，该Pt配合物由通式[Pt(XYZ)C]+B‑表示，其中，XYZ是由下式(1a)或(1b)提供的三齿配位基：C是由下式(2)提供的单齿配位基。本发明涉及上述含喹唑啉类配体的Pt配合物的制备方法。本发明还提供了上述含喹唑啉类配体的Pt配合物或者上述制备方法所制得的含喹唑啉类配体的Pt配合物在制备作为EGFR抑制剂的药物以及在制备肿瘤或癌症药物中的应用。本发明所提供的含喹唑啉类配体的Pt配合物能够靶向性地作用于受体EGFR高表达的肿瘤或癌症细胞，从而降低对正常细胞的毒副作用。并且还具有优良的肿瘤或癌症细胞的增殖抑制活性。

  公开号：

  CN106188147B

文献信息

• Light-Emitting Tridentate Cyclometalated Platinum(II) Complexes Containing σ-Alkynyl Auxiliaries:  Tuning of Photo- and Electrophosphorescence
  作者：Wei Lu、Bao-Xiu Mi、Michael C. W. Chan、Zheng Hui、Chi-Ming Che、Nianyong Zhu、Shuit-Tong Lee

  DOI：10.1021/ja0317776

  日期：2004.4.1

  sigma-alkynyl ligands, the emission color of this class of platinum(II) complexes can be tuned from green-yellow to saturated red. In addition to (3)MLCT [Pt(5d) --> pi*(C/N/N)] and (3)IL(C/N/N), intriguing (3)IL(alkynyl) excited states localized on -(C[triple bond]C)(4)- and -(C[triple bond]Cpyrenyl-1) moieties that afford narrow-bandwidth emissions have been observed. Selected Pt(II) complexes were doped into

  该配合物在具有高量子产率和微秒寿命的流体和玻璃溶液中显示出良好的热稳定性和强烈的磷光。它们的发射能量对溶剂极性、环金属化和芳基乙炔基上的取代基的电子亲和力以及寡炔基配体的长度敏感。通过选择合适的环金属化和 σ-炔基配体，这类铂 (II) 配合物的发射颜色可以从绿黄色调到饱和红色。除了 (3) MLCT [Pt(5d) --> pi*(C/N/N)] 和 (3)IL(C/N/N) 之外，有趣的 (3)IL(炔基) 激发态位于-(C[三键]C)(4)-和-(C[三键]Cpyrenyl-1)部分提供窄带发射已经被观察到。将选定的 Pt(II) 配合物掺杂到多层的发射区中，气相沉积有机发光二极管。可调电致磷光能量类似于这些发射器的流体溶液中记录的能量，并且这些设备表现出高亮度和效率（高达 4.2 cd A(-1)）。
• Dinuclear platinum(ii) 4,6-diphenyl-2,2′-bipyridine complexes tethered by a rigid bridging ligand: synthesis and photophysics in solution and in LB film
  作者：Iswarya Mathew、Yunjing Li、Zhongjing Li、Wenfang Sun

  DOI：10.1039/c0dt00597e

  日期：——

  transfer) and 1π,π* transitions. Both complexes are emissive in solutions at room temperature and in glassy matrix at 77 K. The emitting state is tentatively assigned as 3MLCT for 1 and 3MLCT/3ILCT/3π,π* for 2 at room temperature. At 77 K, the emission observed for 1 is mainly from the emissive ground-state aggregates, which is concentration dependent; while in 2 the emission from the monomer dominates. Unlike

  两个双核 铂（II）4,6-二苯基-2,2'-联吡啶 （C ^ N ^ N）具有刚性桥联配体的配合物（1和2）顺式-1,2-双（二苯基膦基）乙烯合成和它们的光物理性质在溶液中进行了系统研究用于1和2以及在LB膜2。成它们相应的单核络合物相似，二者配合物表现出强烈1个π，π*吸收在可见光区域，这可能从混合茎UV区和宽的，中等吸收带1 MLCT（金属-配体电荷转移） ，1个ILCT（配体内电荷转移）和1个π，π*跃迁。两种络合物在室温下均在溶液中发光，在77 K时在玻璃状基质中发光。发射态暂定为1和3的3 MLCT。MLCT / 3 ILCT / 3 π，π*为2在室温下。在77 K时，观测到的1的发射主要来自基态的发射态聚集体，这与浓度有关；而在2中，单体的发射占主导地位。不像双核铂 具有柔性桥联配体的复合物 二苯基膦乙烷，室温下1和2的电子吸收和发射能量与它们的浓度无关，这表明这两种配合物具有固定的构象。另外，存在烷氧基
• Luminescent oligo(ethylene glycol)-functionalized cyclometalated platinum(ii) complexes: cellular characterization and mitochondria-specific localization
  作者：Zhengqing Guo、Wah-Leung Tong、Michael C. W. Chan

  DOI：10.1039/c3cc47150k

  日期：——

  A readily tunable series of non-planar oligo(ethylene glycol)-substituted phosphorescent Pt(II) complexes has been investigated as live cell imaging agents; suitable structural modifications can give good cellular uptake, traceable mitochondria-specific localization and potent cytotoxic characteristics towards HeLa cells.

  研究人员对一系列非平面寡聚（乙二醇）取代的磷光铂（II）复合物进行了研究，并将其作为活细胞成像剂；适当的结构修饰可以带来良好的细胞吸收、可追踪的线粒体特异性定位以及对 HeLa 细胞的强力细胞毒性特性。
• Trinuclear Platinum(II) 4,6-Diphenyl-2,2‘-bipyridyl Complex with Bis(diphenylphosphinomethyl)phenylphosphine Auxiliary Ligand:  Synthesis, Structural Characterization, and Photophysics
  作者：Pin Shao、Wenfang Sun

  DOI：10.1021/ic700757x

  日期：2007.10.1

  trinuclear cyclometalated Pt(II) 4,6-diphenyl-2,2'-bipyridyl complex with bis(diphenylphosphinomethyl)phenylphosphine bridging ligand ([4-Ph(C--N--N)Pt](3)dpmp) has been synthesized and characterized. It exhibits a broad electronic absorption band from 400 to 600 nm because of its intramolecular Pt...Pt interactions that have been revealed by X-ray crystal structure analysis. This complex shows strong red emission

  具有双（二苯基膦甲基）苯基膦桥联配体（[4-Ph（C--N--N）Pt]（3）dpmp）的三核环金属化Pt（II）4,6-二苯基-2,2'-联吡啶基配合物具有合成并表征。由于其分子内的Pt ... Pt相互作用已通过X射线晶体结构分析揭示，因此它显示了从400至600 nm的宽电子吸收带。该络合物在室温和77 K下在乙腈中显示出强烈的红色发射。电子光谱和发射光谱显示出浓度和温度依赖性。随着浓度的增加，吸收光谱的紫外谱带逐渐减小并加宽，伴随着在400至600 nm之间的（1）[dsigma *，pi *]谱带的增大。对于发射光谱，源自单核铂（II）组分的550 nm谱带随着浓度的增加而逐渐减小，而对应于（3）[dsigma *，pi *]状态的约700 nm谱带则逐渐增加。另外，UV-可见光谱和发射光谱表现出温度和粘度依赖性。浓度，温度和粘度相关的特性表明配合物的构象变化是由沿寡膦酸根轴的旋
• Probing d⁸−d⁸ Interactions in Luminescent Mono- and Binuclear Cyclometalated Platinum(II) Complexes of 6-Phenyl-2,2‘-bipyridines
  作者：Siu-Wai Lai、Michael Chi-Wang Chan、Tsz-Chun Cheung、Shie-Ming Peng、Chi-Ming Che

  DOI：10.1021/ic990238s

  日期：1999.9.1

  A series of luminescent mono- and binuclear cyclometalated platinum(II) complexes, namely [Pt(L1-6)Cl] (1a-6a; HL1-6 = 4-(aryl)-6-phenyl-2,2'-bipyridine; aryl = H (1), phenyl (2), 4-chlorophenyl (3), 4-tolyl (4), 4-methoxyphenyl (5), 3,4,5-trimethoxyphenyl (6)), [Pt(L-1)E](+) (E = py (7), PPh3 (8)), [Pt-2(L1-6)(2)(mu-dppm)](2+) (1b-6b, dppm = bis(diphenylpbosphino)methane), [Pt-2(L-1)(2)(mu-pz)](+) (9, Hpz = pyrazole), and [Pt-2(L-1)(2)(mu-dppcC(n))](2+) (dppC(n) = bis(diphenylphosphino)propane (10, n = 3) and -pentane (11, n = 5)), were synthesized in order to examine fluid- and solid-state oligomeric d(8)-d(8) and ligand-ligand interactions. The molecular structures of 4b(ClO4)(2) and 9(PF6) reveal intramolecular Pt-Pt distances of 3.245(1) and 3.612(2) Angstrom, respectively. While minimal metal-metal communication is expected for 9, weak pi-pi interactions are possible. All complexes described in this work are emissive in fluid solution at room temperature. Negligible changes in emission energy are detected by incorporating different aryl substituents into the 4-position of 6-phenyl-2,2'-bipyridine, and this indicates little electronic delocalization between them. Self-quenching of the (MLCT)-M-3 emission by the mononuclear derivatives are observed in CH2Cl2 at 298 K, and a red shia in the emission energy is exhibited by complex 7 in acetonitrile at 77 K. The fluid emissions of the mu-dppm species 1b-6b at lambda(max) 652-662 nm appear at substantially lower energies than their mononuclear counterparts and show dramatic solvatochromic effects. These emissions are ascribed to (3)[d sigma*, pi*] excited states. In contrast, the emission of 10 and 11, bearing long bridging diphosphine ligands, are attributed to (MLCT)-M-3 states of non-interacting [Pt(L-1)] moieties. Significantly, the luminescence of the mu-pyrazolate complex 9 displays transitional features which are reminiscent of both (3)[d sigma*, pi*] and (MLCT)-M-3 excited states. Hence a relationship is observed between emission energy, the nature of the lowest energy excited state, and metal-metal interactions. The excited-state redox potential [E(*Pt-2(2+)/Pt-2(+))] of 1b has been estimated by electrochemical studies (1.61 V vs NHE) and by quenching experiments with aromatic hydrocarbons (1.63 V vs NHE).