methyl(phenyl)(triisopropylsilyl)phosphine | 1001350-30-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl(phenyl)(triisopropylsilyl)phosphine
• 英文别名: methylphenyl(triisopropylsilyl)phosphine；Methyl-phenyl-tri(propan-2-yl)silylphosphane
• CAS: 1001350-30-6
• 化学式: C₁₆H₂₉PSi
• 分子量: 280.466
• InChiKey: WBMUJQRZLDFAJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  methyl(phenyl)(triisopropylsilyl)phosphine 、 2-iodo-N,N-diisopropylbenzamide 在 [(R,R)-Et-FerroTANE]PdCl₂ sulfur 作用下， 以 various solvent(s) 为溶剂， 反应 3.5h， 以53%的产率得到
  参考文献：
  名称：

  Pd-Catalyzed Dynamic Kinetic Enantioselective Arylation of Silylphosphines

  摘要：

  Palladium-catalyzed cross-couplings represent a powerful method for the formatioil of new bonds. A catalytic, enantioselective P-C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo-N ,N -diisopropylbenzamides.

  DOI：

  10.1021/ja076457r
• 作为产物：
  描述：

  三异丙基氯硅烷 、 甲基(苯基)膦 在 sodium hexamethyldisilazane 作用下， 以 乙醚 为溶剂， 反应 16.3h， 生成 methyl(phenyl)(triisopropylsilyl)phosphine
  参考文献：
  名称：

  Pd-Catalyzed Dynamic Kinetic Enantioselective Arylation of Silylphosphines

  摘要：

  Palladium-catalyzed cross-couplings represent a powerful method for the formatioil of new bonds. A catalytic, enantioselective P-C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo-N ,N -diisopropylbenzamides.

  DOI：

  10.1021/ja076457r

文献信息

• Pd-Catalyzed Dynamic Kinetic Enantioselective Arylation of Silylphosphines
  作者：Vincent S. Chan、Robert G. Bergman、F. Dean Toste

  DOI：10.1021/ja076457r

  日期：2007.12.1

  Palladium-catalyzed cross-couplings represent a powerful method for the formatioil of new bonds. A catalytic, enantioselective P-C bond-forming reaction proceeding via a Pd-mediated arylation of silylphosphines was developed for the synthesis of P-stereogenic phosphines. These useful and synthetically challenging phosphines can be made with a variety of functionalized aryl iodides; however, they proceed most enantioselectively with 2-iodo-N ,N -diisopropylbenzamides.