(2S,4S,5R)-3,4-dimethyl-2-(4-methylphenyl)-5-phenyloxazolidine | 653600-78-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4S,5R)-3,4-dimethyl-2-(4-methylphenyl)-5-phenyloxazolidine
• 英文别名: Oxazolidine, 3,4-dimethyl-2-(4-methylphenyl)-5-phenyl-, (2S,4S,5R)-；(2S,4S,5R)-3,4-dimethyl-2-(4-methylphenyl)-5-phenyl-1,3-oxazolidine
• CAS: 653600-78-3
• 化学式: C₁₈H₂₁NO
• 分子量: 267.371
• InChiKey: PMCXNOIHCLVZPH-WBAXXEDZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  麻黄碱 、 对甲基苯甲醛 以 氯仿 为溶剂， 反应 0.08h， 以92%的产率得到(2S,4S,5R)-3,4-dimethyl-2-(4-methylphenyl)-5-phenyloxazolidine
  参考文献：
  名称：

  Comparison of Conventional and Microwave Assisted Reactions Giving Aromatic Oxazolidines

  摘要：

  By reaction of aromatic aldehydes with (-)-ephedrine aromatic 1,3-oxazolidines can be obtained. The reaction was carried out either at conventional conditions or by microwave heating. The different diastereomeric ratios were determined by Means of H-1 NMR spectroscopy.

  DOI：

  10.1007/s00706-003-0020-6

文献信息

• Comparison of Conventional and Microwave Assisted Reactions Giving Aromatic Oxazolidines
  作者：Florian Diwischek、Eberhard Heller、Ulrike Holzgrabe

  DOI：10.1007/s00706-003-0020-6

  日期：2003.8.1

  By reaction of aromatic aldehydes with (-)-ephedrine aromatic 1,3-oxazolidines can be obtained. The reaction was carried out either at conventional conditions or by microwave heating. The different diastereomeric ratios were determined by Means of H-1 NMR spectroscopy.