N,N'-di(6-methyl-2-pyridyl)formamidine | 23646-50-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N,N'-di(6-methyl-2-pyridyl)formamidine
• 英文别名: bis(6-methyl-2-pyridyl)formamidine；N,N'-bis-(6-methyl-pyridin-2-yl)-formamidine；HDMepyF；N,N'-bis(6-methylpyridin-2-yl)methanimidamide
• CAS: 23646-50-6
• 化学式: C₁₃H₁₄N₄
• 分子量: 226.281
• InChiKey: NHZPGBFNFJOHEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  50.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  五羰基溴铼(I) 、 N,N'-di(6-methyl-2-pyridyl)formamidine 以 四氢呋喃 为溶剂， 以52%的产率得到BrRe(CO)3(N,N'-di(6-methyl-2-pyridyl)formamidine)
  参考文献：
  名称：

  一些含有二吡啶基甲form配体的羰基金属配合物的合成和X射线结构

  摘要：

  报道了N，N′-二（2-吡啶基）甲idine（HDpyF）和N，N′-二（6-甲基-2-吡啶基）甲idine（HDMepyF）的五种羰基金属配合物。ReBr（CO）3 L（L = HDpyF，1 ; L = HDMepyF，2）型配合物分别通过ReBr（CO）5与HDpyF和HDMepyF在THF中的反应制备，而配合物M（CO）通过HDpyF或HDMepyF与相应的第6族六羰基金属的反应制备4（L）（M = Mo，L = HDpyF，3 ; M = Mo，L = HDMepyF，4 ; M = W，L = HDMepyF，5） 。中性dipyridylformamidine配体1和2采用小号-顺式-顺式-小号-顺式和小号-反式-反-小号-反式构象，分别，而在复合物3 - 5采用小号-反式-反-小号-顺式构象。

  DOI：

  10.1016/s0022-328x(03)00042-1
• 作为产物：
  描述：

  2-氨基-6-甲基吡啶 、 原甲酸三乙酯 反应 19.0h， 生成 N,N'-di(6-methyl-2-pyridyl)formamidine
  参考文献：
  名称：

  甲am中的胺交换：实验和理论研究

  摘要：

  Ñ  -含有H甲脒结合相当强关联为羧酸，以形成良好限定的几何形状的络合物以同时质子诱导的亲电性的增强，其允许它们的胺部分的交换。所述NC（H） NH片段，因此，经过“亚胺样”与含N亲核试剂交换。由于质子的平衡，所述NC（H） NH片段可以表现为“双亚胺”为中心在相同的碳，其中两个含N片段可以被交换。同时考虑C的质子诱导致敏N单元和明确定义的甲am-羧酸配合物几何形状，应该可以使用羧酸作为模板，通过甲form内的动态胺交换来合成确定的结构。这项研究重点介绍了基于进料胺（脂肪族胺，芳香族胺和烷氧基胺）性质的三种交换方式，以及基于胺离去基团的交换规则。经过该分析，提供了通过动态交换形成羧酸模板化大环化合物的概念证明。

  DOI：

  10.1002/chem.201002389

文献信息

• Chemistry of dimolybdenum complexes containing anions of N,N′-di(6-methyl-2-pyridyl)formamidine (HDMepyF) and carboxylate ligands
  作者：Hsiao-Yun Weng、Chih-Wei Lee、Yao-Yin Chuang、Maw-Cherng Suen、Jhy-Der Chen、Chen-Hsiung Hung

  DOI：10.1016/s0020-1693(03)00183-x

  日期：2003.7

  Reactions of Mo2(O2CCF3)4 and Mo2(O2C(CH2)nCH3)4 with N,N′-di(6-methyl-2-pyridyl)formamidine (HDMepyF) in CH2Cl2 afforded complexes of the types Mo2(O2CCF3)2(DMepyF)2, 1, and Mo2(O2C(CH2)nCH3)2(DMepyF)2 (n=0, 2; n=2, 3; n=5, 4; n=8, 5; n=14, 6), respectively. Their structures have been determined by X-ray crystallography. The molecular structures of complexes 1–6 consist of two quadruply bonded molybdenum

  摘要Mo2（O2CCF3）4和Mo2（O2C（CH2）nCH3）4与N，N'-二（6-甲基-2-吡啶基）甲form（HDMepyF）在 Cl2中的反应提供了Mo2（O2CCF3）2型配合物（DMepyF）2，1，和Mo2（O2C（ ）nCH3）2（DMepyF）2（n = 0，2; n = 2，3; n = 5，4; n = 8，5; n = 14， 6）。它们的结构已经通过X射线晶体学确定。配合物1-6的分子结构由两个四重键合的钼原子组成，它们被两个反式桥接的form酰胺配体和两个反式桥接的羧酸酯配体所跨越。甲酰胺基配体通过两个中心氮原子以二齿形式与Mo中心配位，并且两个末端吡啶基环悬空。DMepyF-配体采用s-顺式，s-反式构象，导致Mo⋯N和Mo⋯HC短距离。
• Dimolybdenum complexes with mixed formamidinate ligands
  作者：Ying-Yann Wu、Ya-Chen Kao、Jhy-Der Chen、Chen-Hsiung Hung

  DOI：10.1016/j.ica.2003.09.019

  日期：2004.3

  A series of dimolybdenum complexes containing mixed formamidinate ligand are discussed. The reactions of trans-Mo-2(O2CCH3)(2)(o-DMophF)(2) [o-HDMophF=N,N'-di(2-methoxyphenyl)formamidine] with N,N'-di(2-pyridyl)formamidine (HD pyF), N,N'-di(2-pyrimidyl)formamidine (HDpmF) and N,N'-di(6-methyl-2-pyridyl)formamidine (HDMepyF), in refluxing CH2Cl2 afforded the complexes, traps-Mo-2(O2CCH3)(DpyF)(o-DMophF)(2) (1), trans-Mo-2(O2CCH3)(DpmF)(o-DMophF)(2) (2), and trans-Mo-2(O2CCH3)(DMepyF)(o-DMophF)(2) (3), respectively. The o-DMophF(-) and DMepyF(-) ligands in these complexes adopt the s-cis, s-trans conformation, resulting in Mo-O short distances [2.889 (3) and 2.861(2) Angstrom for 1; 2.880(3) and 3.024(4) Angstrom for 2], while the DpyF(-) ligand adopts the s-cis, s-trans conformation, resulting in a Mo-N [3.208(4) Angstrom] and a Mo-H [2.90 (3) Angstrom] short distances. The reactions of trans-Mo-2(O2CCH3)(2)(o-DMophF)(2) with HDMepyF in CH3CN gave complexes 3, trans-Mo-2(O2CCH3)(DMepyF)(2)(o-DMophF) (4), and trans-Mo-2(DMepyF)(2)(o-DMophF)(2) (5). The o-DMophF(-) ligands in 4 and 5 adopt the s-cis, s-cis conformation while DMepyF(-) assumes an s-cis, s-trans conformation. Complexes 1-5 are the first dimolybdenum complexes containing mixed formamidinate ligands. (C) 2003 Elsevier B.V. All rights reserved.
• Structural characterization of copper complexes containing N,N′-di(6-methyl-2-pyridyl)formamidine
  作者：Chih-Wei Lee、Zhi-Kai Chan、Tsun-Ren Chen、Jhy-Der Chen

  DOI：10.1016/s0020-1693(02)01478-0

  日期：2003.5

  The reactions of N,N'-di(6-methyl-2-pyridyl)formamidine (HDMepyF) with copper halide produced complexes of the types CuCl2(HDMepyF) (1), Cu2X4(HDMepyF)(2) (X = Cl, 2; X = Br 3), Cu4I4(HDMepyF)(2) (4), and [Cu,(HDMepyF)(2)](PF6)(2) (5). All complexes were characterized by X-ray crystallography. The structure of I is tetrahedral with the Cu(II) center chelated by one HDMepyF ligand and coordinated by two chloride ligands. Complexes 2 and 3 are dinuclear complexes, in which the two Cu(II) centers are bridged by two halide atoms. Each Cu(II) metal center are also coordinated by one terminal halide atom and chelated by one HDMepyF ligand, forming a distorted square-pyramidal geometry. Complex 4 is tetranuclear with the four copper atoms forming a parallelogram and each Cu atom being in a three-coordination environment. One iodo atom and one HDMepyF ligand bridge two adjacent copper atoms. In complexes 1-4, the neutral HDMepyF ligands coordinate to the metal centers through one amine nitrogen atom and one adjacent pyridine nitrogen atom. In dinuclear complex 5, the HDMepyF ligands coordinate to the Cu(I) ions in a tridentate fashion, forming a chelating and a bridging bonding modes. The molecules of 5 are chiral due to the ligand constraints and each Cu atom forms a trigonal-planar geometry. All the HDMepyF ligands in complexes 1-5 adopt the s-cis, s-trans conformation. (C) 2002 Elsevier Science B.V. All rights reserved.
• Dicadmium complexes bearing tetradentate formamidinate ligands with triple helical structures
  作者：Wen-Bin Lin、Hsiu-Chi Liang、Jhy-Der Chen、Tai-Chiun Keng、Ju-Chun Wang

  DOI：10.1016/s0020-1693(02)00842-3

  日期：2002.7

  Reactions of Cd(NO3)(2)(.)4H(2)O with bis(2-pyridyl)formamidine (HDpyF) and bis(6-methyl-2-pyridyl)formamidine (HDMepyF) in CH3OH afforded the dinuclear products, [Cd-2(DpyF)(3)][Cd(NO3)(4)](0.5) (1), and [Cd-2(DMepyF)(3)](NO3) (2). respectively. Their structures were determined by X-ray crystallography. Complex I crystallized in two different space groups with different packing solvents. Both the DpyF(-) and DMepyF(-) ligands are coordinated to the Cd atoms in new tetradentate fashions, forming two chelating and four bridging bonding modes. Each cadmium metal center of the cations is tris-chelated and strongly distorted from octahedral coordination due to the small bite of the DpyF(-) and DMepyF(-) ligands. The molecules of the cations are chiral due to the ligand constraints. They are the first dicadmium complexes bearing formamidinate ligands with triple helical structures. 2002 Elsevier Science B.V. All rights reserved.
• US4021437A
  申请人：——

  公开号：US4021437A

  公开（公告）日：1977-05-03