6H-dibenzothiopyran-S,S-dioxid | 32018-39-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻喃类
• 英文名称: 6H-dibenzothiopyran-S,S-dioxid
• 英文别名: 6H-Dibenzothiopyran-5,5-dioxid；6H-Dibenzo[b,d]thiopyran-S,S-dioxid；6H-benzo[c]thiochromene 5,5-dioxide
• CAS: 32018-39-6
• 化学式: C₁₃H₁₀O₂S
• 分子量: 230.287
• InChiKey: IIYSCCYSGZXSTI-UHFFFAOYSA-N

物化性质

• 熔点：
  140-142 °C(Solv: ethanol (64-17-5))
• 沸点：
  473.8±28.0 °C(Predicted)
• 密度：
  1.333±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6H-dibenzothiopyran-S,S-dioxid 在 potassium tert-butylate 作用下， 以 乙腈 为溶剂， 反应 12.5h， 生成 (E)-6-(Methoxymethylen)-6H-dibenzothiopyran-5,5-dioxid
  参考文献：
  名称：

  Schank, Kurt; Werner, Frank, Liebigs Annalen der Chemie, 1983, # 10, p. 1739 - 1743

  摘要：

  DOI：
• 作为产物：
  描述：

  6H-dibenzothiopyran 在 双氧水 、 溶剂黄146 作用下， 反应 3.0h， 以90%的产率得到6H-dibenzothiopyran-S,S-dioxid
  参考文献：
  名称：

  Unterhalt; Bruening, Scientia Pharmaceutica, 1997, vol. 65, # 1-2, p. 1 - 10

  摘要：

  DOI：

文献信息

• Palladium-Catalysed Intramolecular Direct Arylation of 2-Bromobenzenesulfonic Acid Derivatives
  作者：Charles Beromeo Bheeter、Jitendra K. Bera、Henri Doucet

  DOI：10.1002/adsc.201200793

  日期：2012.12.14

  arylation of 2-bromobenzenesulfonic acid derivatives was found to proceed using 1 mol% of palladium acetate as the catalyst. The influence of the substituents on the phenol moiety of 2-bromobenzenesulfonic acid phenyl esters reveals that electron-donating substituents favour the reaction while electron-withdrawing ones are unfavourable. The reactivity of sulfonamides was also studied and, in all cases

  发现使用1mol％乙酸钯作为催化剂进行2-溴苯磺酸衍生物的钯催化的分子内直接芳基化。取代基对2-溴苯磺酸苯基酯的酚部分的影响表明，供电子取代基有利于反应，而吸电子取代基不利。还研究了磺酰胺的反应性，并且在所有情况下，均观察到sp 2 CH与sp 3 CH的选择性活化。在氮上同时带有苯基和苄基取代基的磺酰胺选择性地产生六元环产物。
• Cellulose Compound Film, Optical Compensation Sheet, Polarizing Plate, and Liquid Crystal Display Device
  申请人：Nozoe Yutaka

  公开号：US20070259134A1

  公开（公告）日：2007-11-08

  A cellulose compound film containing a cellulose compound having two or more substituents whose polarizability anisotropies Δα calculated by mathematical formula (1) are different from each other, wherein substitution degrees of the following substituents A and B in the cellulose compound satisfy relationship as defined by mathematical formula (A1), in which the substituent A has the lowest Δα and the substituent B has the highest Δα: Δ ⁢ ⁢ α = α ⁢ ⁢ x - α ⁢ ⁢ y + α ⁢ ⁢ z 2 Mathematical ⁢ ⁢ formula ⁢ ⁢ ( 1 ) wherein, in characteristic values obtained after diagonalization of polarizability tensor, αx is the largest component, αy is the second largest component, and αz is the smallest component; DS B 2+ DS B 3− DS B 6≧−0.1   Mathematical formula (A1) wherein DS B 2, DS B 3, and DS B 6 represent a substitution degree of the substituent B at the 2-, 3-, or 6-position of a β-glucose ring constituting unit of cellulose, respectively; and an optical compensation film, a polarizing plate, and a liquid crystal display device, using the cellulose compound film.

  一种纤维素化合物薄膜，其含有具有两个或更多取代基的纤维素化合物，其极化率各向异性Δα通过数学公式（1）计算得出，其中以下取代基A和B的取代度满足数学公式（A1）所定义的关系，其中取代基A具有最低的Δα，而取代基B具有最高的Δα：Δα = αx-αy + αz2数学公式（1）其中，在极化率张量对角化后获得的特征值中，αx是最大分量，αy是第二大分量，αz是最小分量;DSB2 + DSB3-DSB6≥-0.1数学公式（A1）其中DSB2、DSB3和DSB6分别表示取代基B在纤维素构成单位β-葡萄糖环的2-、3-或6-位置的取代度;以及使用该纤维素化合物薄膜的光学补偿膜、偏光板和液晶显示装置。
• Cellulose Acylate Film, Method of Producing the Same, Cellulose Derivative Film, Optically Compensatory Film Using the Same, Optically-Compensatory Film Incorporating Polarizing Plate, Polarizing Plate and Liquid Crystal Display Device
  申请人：Haruta Hiromoto

  公开号：US20090290100A1

  公开（公告）日：2009-11-26

  A method of producing a cellulose derivative film, the method comprising: forming a film with a solvent cast method from a dope including a cellulose derivative satisfying following conditions (a) and (b): (a) at least one among three hydroxyl groups included in a glucose unit of cellulose is substituted by a substituent of which a polarizability anisotropy Δα represented as following Expression (1) is 2.5×10 −24 cm 3 or higher: Expression (1): Δα=αx−(αy+αz)/2, wherein αx, αy and αz is as defined in the specification; and (b) when a substitution degree by a substituent of which Δα is 2.5×10 −24 cm 3 or higher is P A , and a substitution degree by a substituent of which Δα is lower than 2.5×10 −24 cm 3 is P B , the P A and P B satisfy following Expressions (3) and (4): Expression (3): 2P A +P B >3.0; and Expression (4): P A >0.2.

  一种生产纤维素衍生物薄膜的方法，该方法包括：使用包括满足以下条件（a）和（b）的纤维素衍生物的溶胶，通过溶剂浇铸法形成薄膜：（a）纤维素的葡萄糖单元中的三个羟基中的至少一个被取代为极化率各向异性Δα（以下表达式（1）表示）为2.5×10-24cm3或更高的取代基：表达式（1）：Δα=αx-（αy+αz）/ 2，其中αx，αy和αz如规范中定义的；并且（b）当Δα为2.5×10-24cm3或更高的取代基的取代度为PA时，Δα低于2.5×10-24cm3的取代基的取代度为PB，PA和PB满足以下表达式（3）和（4）：表达式（3）：2PA + PB> 3.0；表达式（4）：PA> 0.2。
• PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DELIVERING SUCH COMPOSITIONS
  申请人：Bentley Michael D.

  公开号：US20120258912A1

  公开（公告）日：2012-10-11

  The present invention provides pharmaceutical compositions comprising a pharmaceutically acceptable excipient and a conjugate having a degradable linkage. The conjugates include at least one of each the following: an aromatic moiety comprising an ionizable hydrogen atom, a spacer moiety, and a water-soluble polymer. Methods for delivering such compositions are also provided.

  本发明提供了含有可降解连接的共轭物的制药组合物，其中包括药用可接受的赋形剂和共轭物。共轭物包括以下至少一种：具有可离解氢原子的芳香基团，间隔基团和水溶性聚合物。本发明还提供了传递这种组合物的方法。
• POLYMERIC REAGENTS COMPRISING A TERMINAL VINYLIC GROUP AND CONJUGATES FORMED THEREFROM
  申请人：Culbertson Sean M.

  公开号：US20120318701A1

  公开（公告）日：2012-12-20

  The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

  本发明提供了具有可降解连接的共轭物和用于制备这种共轭物的高分子试剂。还提供了制备高分子试剂和共轭物的方法，以及给予共轭物和组合物的方法。