2-hydroxy-N-(2,4,5-trichloro-phenyl)-benzamide | 106480-61-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-N-(2,4,5-trichloro-phenyl)-benzamide
• 英文别名: Salicylsaeure-<2.4.5-trichlor-anilid>；2-hydroxy-N-(2,4,5-trichlorophenyl)benzamide
• CAS: 106480-61-9
• 化学式: C₁₃H₈Cl₃NO₂
• 分子量: 316.571
• InChiKey: BGEMAKTZPJNUSX-UHFFFAOYSA-N

物化性质

• 沸点：
  367.4±42.0 °C(Predicted)
• 密度：
  1.562±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-hydroxy-N-(2,4,5-trichloro-phenyl)-benzamide 、 氯甲酸乙酯 在 吡啶 作用下， 以 乙腈 为溶剂， 生成 3-(2,4,5-trichloro-phenyl)-benzo[e][1,3]oxazine-2,4-dione
  参考文献：
  名称：

  取代的3-苯基-1,3-苯并恶嗪-2,4-二酮及其抑菌活性。

  摘要：

  DOI：

  10.1021/jm00338a034

文献信息

• Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes
  申请人：NAN Global, LLC

  公开号：US10849872B2

  公开（公告）日：2020-12-01

  The present invention relates to compositions and kits including a chemical uncoupler, such as tyrphostin 9 or precursor or a salt thereof, and compositions including a chemical uncoupler, such as tyrphostin 9 in combination with one or more therapeutic agents, for example, L-carnitine, which are useful, for example, in treating obesity, preventing weight gain, promoting weight loss/slimming, and/or treating or preventing the development of diabetes.

  本发明涉及包括化学解偶联剂的组合物和试剂盒，如tyrphostin 9或其前体或盐，以及包括化学解偶联剂的组合物，如tyrphostin 9与一种或多种治疗剂（例如左旋肉碱）的组合物，这些组合物在治疗肥胖症、防止体重增加、促进减肥/瘦身和/或治疗或预防糖尿病发展等方面有用。
• METHODS AND COMPOSITIONS FOR TREATING OBESITY, PREVENTING WEIGHT GAIN, PROMOTING WEIGHT LOSS, PROMOTING SLIMMING, OR TREATING OR PREVENTING THE DEVELOPMENT OF DIABETES
  申请人：NAN Global, LLC

  公开号：US20160000745A1

  公开（公告）日：2016-01-07

  The present invention relates to compositions and kits including a chemical uncoupler, such as tyrphostin 9 or precursor or a salt thereof, and compositions including a chemical uncoupler, such as tyrphostin 9 in combination with one or more therapeutic agents, for example, L-carnitine, which are useful, for example, in treating obesity, preventing weight gain, promoting weight loss/slimming, and/or treating or preventing the development of diabetes.
• Substituted 3-Phenyl-1,3-benzoxazine-2,4-diones and their Bacteriostatic Activity
  作者：Raymond E. Stenseth、Joseph W. Baker、Daniel P. Roman

  DOI：10.1021/jm00338a034

  日期：1963.3