cyclohexyl N-(4-aminophenyl)carbamate | 20995-16-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cyclohexyl N-(4-aminophenyl)carbamate
• 英文别名: cyclohexyl (4-aminophenyl)carbamate
• CAS: 20995-16-8
• 化学式: C₁₃H₁₈N₂O₂
• mdl: MFCD12414579
• 分子量: 234.298
• InChiKey: HWGZISRAIVADBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  cyclohexyl N-(4-aminophenyl)carbamate 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 生成
  参考文献：
  名称：

  Some chemical transformations of alkyl (4-aminophenyl)carbamates

  摘要：

  Azo coupling of diazonium salts derived from alkyl (4-aminophenyl)carbamates with ethyl alpha-methylacetoacetate gave ethyl 5-alkoxycarbonylamino-1H-indole-2-carboxylates. The condensation of aminophenylcarbamates with aromatic aldehydes in ethanol afforded the corresponding Schiff bases. Cyclohexyl {4-[(4-methoxyphenyl)methylidene]aminophenyl}carbamate reacted with chloroacetyl chloride in dioxane in the presence of triethylamine to produce cyclohexyl {4-[3-chloro-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]phenylcarbamate, and the reaction of benzyl {4-[(4-nitrophenyl)methylidene]aminophenyl}carbamate with sulfanylacetic acid in DMF led to the formation of benzyl {4-[2-(4-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]-phenyl}carbamate.

  DOI：

  10.1134/s1070428013070087
• 作为产物：
  描述：

  苯基氨基甲酸环己酯 在 sodium dithionite 、 HSO₃ONO 作用下， 以 1,4-二氧六环 、 水 、 溶剂黄146 为溶剂， 反应 1.0h， 生成 cyclohexyl N-(4-aminophenyl)carbamate
  参考文献：
  名称：

  Velikorodov, Russian Journal of Organic Chemistry, 2000, vol. 36, # 2, p. 233 - 239

  摘要：

  DOI：

文献信息

• Synthesis of N-arylcarbamates with tetrazole fragment and some their derivatives
  作者：A. V. Velikorodov、N. N. Stepkina、V. A. Ionova、E. A. Melent’eva

  DOI：10.1134/s1070428014080193

  日期：2014.8
• Synthesis of New Derivatives of 5-Acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione
  作者：A. V. Velikorodov、A. S. Zukhayrayeva、V. P. Osipova、M. A. Polovinkina

  DOI：10.1134/s1070428019120121

  日期：2019.12

  5-Acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione reacted with cyclohexyl and benzyl (4-aminophenyl)carbamates in boiling ethanol in the presence of a catalytic amount of glacial acetic acid to give the corresponding Schiff bases, cyclohexyl and benzyl (4-[(E)-1-(4-hydroxy-2,6-dioxo-3,6-dihydro-2H-1,3-thiazin-5-yl)ethylidene]amino}phenyl)carbamates. Heating of the latter in dimethylformamide for 2 h was accompanied by evolution of COS with the formation of cyclohexyl and benzyl 4-[6-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl]phenyl}carbamates. The condensation of the title compound with benzene-1,2-diamine in propan-2-ol, followed by addition of 5-arylfuran-2-carbaldehyde and trifluoroacetic acid afforded 5-(2-5-[4-bromo(nitro)phenyl]furan-2-yl}-2,3-dihydro-1H-1,5-benzodiazepin-4-yl)-4-hydroxy-2H-1,3-thiazine-2,6(3H)-diones. 5-((E)-3-5-[4-Bromo(nitro)phenyl]furan-2-yl}prop-2-enoyl)-4-hydroxy-2H-1,3-thiazine-2,6(3H)-diones were synthesized by condensation of 5-acetyl-4-hydroxy-2H-1,3-thiazine-2,6(3H)-dione with 5-[4-bromo(nitro)phenyl]furan-2-carbaldehydes in chloroform in the presence of catalytic amounts of pyridine and piperidine.
• Velikorodov, Russian Journal of Organic Chemistry, 2000, vol. 36, # 2, p. 233 - 239
  作者：Velikorodov

  DOI：——

  日期：——
• Some chemical transformations of alkyl (4-aminophenyl)carbamates
  作者：A. V. Velikorodov、V. A. Ionova、S. I. Temirbulatova、M. A. Suvorova

  DOI：10.1134/s1070428013070087

  日期：2013.7

  Azo coupling of diazonium salts derived from alkyl (4-aminophenyl)carbamates with ethyl alpha-methylacetoacetate gave ethyl 5-alkoxycarbonylamino-1H-indole-2-carboxylates. The condensation of aminophenylcarbamates with aromatic aldehydes in ethanol afforded the corresponding Schiff bases. Cyclohexyl 4-[(4-methoxyphenyl)methylidene]aminophenyl}carbamate reacted with chloroacetyl chloride in dioxane in the presence of triethylamine to produce cyclohexyl 4-[3-chloro-2-(4-methoxyphenyl)-4-oxoazetidin-1-yl]phenylcarbamate, and the reaction of benzyl 4-[(4-nitrophenyl)methylidene]aminophenyl}carbamate with sulfanylacetic acid in DMF led to the formation of benzyl 4-[2-(4-nitrophenyl)-4-oxo-1,3-thiazolidin-3-yl]-phenyl}carbamate.