申请人:Bergeron Philippe
公开号:US20120165313A1
公开(公告)日:2012-06-28
Disclosed are compounds of Formula I, including steroisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, that are useful in modulating PIKK related kinase signaling, e.g., mTOR, and for the treatment of diseases (e.g., cancer) that are mediated at least in part by the dysregulation of the PIKK signaling pathway (e.g., mTOR).
本发明揭示了I式化合物,包括立体异构体、几何异构体、互变异构体、溶剂化物、代谢物和药学上可接受的盐,对于调节PIKK相关激酶信号传导,例如mTOR,并用于治疗通过PIKK信号通路(例如mTOR)失调至少部分介导的疾病(例如癌症)是有用的。