1-butoxy-4-phenoxybenzene | 85090-22-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-butoxy-4-phenoxybenzene
• CAS: 85090-22-8
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: NSCFOXCKETUFMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-苯氧基苯酚 、 正丁醇 在 1,3,4-三苯基-4,5-二氢-1H-1,2,4-三氮唑-5-亚基 、 3,3',5,5'-四叔丁基-4,4'-联苯醌 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以56%的产率得到1-butoxy-4-phenoxybenzene
  参考文献：
  名称：

  N-杂环卡宾介导的醇的氧化还原缩合。

  摘要：

  具有各种氧化剂的N-杂环卡宾（NHC）可以促进醇与酚，羧酸和邻苯二甲酰亚胺的Mitsunobu型偶联反应。使用手性醇的实验表明，取决于所用溶剂的极性，这些反应通过SN1或SN2途径进行。NHC作为还原剂被消耗掉，形成易于分离的副产物的氧化物。

  DOI：

  10.1039/c6cc04154j

文献信息

• 2-PHENYLNICOTINIC ACID DERIVATIVE
  申请人：Menjo Nobuo

  公开号：US20100004459A1

  公开（公告）日：2010-01-07

  The present invention is to provide the compounds useful as a treating or preventing agent for gout and hyperuricemia which are 2-phenylnicotinic acid derivatives having a uric acid lowering action due to an excellent xanthine oxidase inhibitory action. Since the 2-phenylnicotinic acid derivatives of the present invention exhibit a uric acid lowering action due to an excellent xanthine oxidase inhibitory action and also hypolipemic action, their utility is very high as a treating or preventive agent for gout and hyperuricemia which are often accompanied by hyperlipemia as a complication.

  本发明提供了一种化合物，它是2-苯基烟酸衍生物，具有出色的黄嘌呤氧化酶抑制作用，可用作痛风和高尿酸血症的治疗或预防剂。由于本发明的2-苯基烟酸衍生物表现出出色的黄嘌呤氧化酶抑制作用和降脂作用，因此它们作为治疗或预防痛风和高尿酸血症的药物，其实用价值非常高，因为这些疾病通常伴随着高脂血症的并发症。
• SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS
  申请人：VANDERBILT UNIVERSITY

  公开号：US20150336925A1

  公开（公告）日：2015-11-26

  The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.

  本发明提供了一种抑制抗凋亡Bcl-2家族成员髓系细胞白血病-1（Mcl-1）蛋白活性的化合物。本发明还提供了制药组合物以及使用化合物治疗因Mcl-1蛋白过度表达或失调而表现出的疾病和症状（例如癌症）的方法。
• Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives
  作者：Xiaolu Jiang、Lu Zhou、Dengguo Wei、Hu Meng、Ying Liu、Luhua Lai

  DOI：10.1016/j.bmcl.2008.10.044

  日期：2008.12

  The synthesis and biological evaluation of a series of diphenyl ether derivatives were described. The compounds can either activate or inhibit the aminopeptidase activity of leukotriene A(4) hydrolase, while at the same time do not influence the hydrolase activity. Further enzyme kinetics and molecular modeling investigation on these novel chemical activators revealed their possible activation mechanism. These compounds can be used as probes to regulate the aminopeptidase activity of leukotriene A4 hydrolase. (C) 2008 Elsevier Ltd. All rights reserved.
• [EN] SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS<br/>[FR] INHIBITEURS DE LA MCL-1 À BASE DE BENZOFURANE, DE BENZOTHIOPHÈNE ET D'INDOLE SUBSTITUÉS
  申请人：UNIV VANDERBILT

  公开号：WO2014047427A2

  公开（公告）日：2014-03-27

  The present invention provides for compounds that inhibit the activity of an anti-apoptotic Bcl-2 family member Myeloid cell leukemia-1 (Mcl-1) protein. The present invention also provides for pharmaceutical compositions as well as methods for using compounds for treatment of diseases and conditions (e.g., cancer) characterized by the over-expression or dysregulation of Mcl-1 protein.
• N-Heterocyclic carbene-mediated redox condensation of alcohols
  作者：Terumasa Kato、Shin-ichi Matsuoka、Masato Suzuki

  DOI：10.1039/c6cc04154j

  日期：——

  N-Heterocyclic carbenes (NHCs) with a variety of oxidants promote the Mitsunobu-type coupling reactions of alcohols with phenols, carboxylic acids, and phthalimide. Experiments using a chiral alcohol indicate that these reactions proceed via SN1 or SN2 pathways depending on the polarity of the used solvents. The NHCs are consumed as reducing reagents to form their oxides as readily separable byproducts

  具有各种氧化剂的N-杂环卡宾（NHC）可以促进醇与酚，羧酸和邻苯二甲酰亚胺的Mitsunobu型偶联反应。使用手性醇的实验表明，取决于所用溶剂的极性，这些反应通过SN1或SN2途径进行。NHC作为还原剂被消耗掉，形成易于分离的副产物的氧化物。