triphenyl (3-(methoxycarbonyl)benzyl)phosphonium chloride | 114302-36-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: triphenyl (3-(methoxycarbonyl)benzyl)phosphonium chloride
• 英文别名: methyl 3-(chloromethyl)benzoate triphenylphosphonium salt；{[3-(Methoxycarbonyl)phenyl]methyl}(triphenyl)phosphanium chloride；(3-methoxycarbonylphenyl)methyl-triphenylphosphanium;chloride
• CAS: 114302-36-2
• 化学式: C₂₇H₂₄O₂P*Cl
• 分子量: 446.913
• InChiKey: OEFJWLNWTABDRW-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.97
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (+/-)-<(3aα,4α,5β,6aα)>-5-(tert-butyldimethylsiloxy)hexahydro-4-<(E)-3,3-ethylenedioxy-4-(4-methylphenoxy)-1-butenyl>-2H-cyclopentafuran-2-ol 、 triphenyl (3-(methoxycarbonyl)benzyl)phosphonium chloride 在 potassium tert-butylate 作用下， 生成 3-((Z)-3-{(1R,2R,3R,5S)-3-(tert-Butyl-dimethyl-silanyloxy)-5-hydroxy-2-[(E)-2-(2-p-tolyloxymethyl-[1,3]dioxolan-2-yl)-vinyl]-cyclopentyl}-propenyl)-benzoic acid methyl ester
  参考文献：
  名称：

  Synthetic Analogues of 15,15-Acetals of Prostaglandin F2α and E2

  摘要：

  两个系列的15,15-乙烯基乙醚类似物，分别对PG F_2α和PG E₂的α-和ω-链进行了改性，旨在寻找更稳定和高效的类似物。这些类似物的合成是从易得的(±)-[(3aα,4α,5β,6aα)]-5-(1,1'-联苯基-4-羰基氧基)-4-甲醛基六氢-2H-环戊[b]呋喃-2-酮（称为Corey醛I）开始的，基于常规程序，其中一些被改进以实现最优收率。

  DOI：

  10.1135/cccc19942533
• 作为产物：
  描述：

  3-(氯甲基)苯甲酰氯 在 吡啶 作用下， 以 1,4-二氧六环 为溶剂， 反应 28.0h， 生成 triphenyl (3-(methoxycarbonyl)benzyl)phosphonium chloride
  参考文献：
  名称：

  Chemical stability of a prostacyclin analog due to the absence of intramolecular catalysis

  摘要：

  DOI：

  10.1021/jo00246a027

文献信息

• Synthesis and Biological Activity of 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Derivatives as Thromboxane A 2 Receptor Antagonists
  作者：Hiroshi Marusawa、Hiroyuki Setoi、Akihiko Sawada、Akio Kuroda、Jiro Seki、Yukio Motoyama、Hirokazu Tanaka

  DOI：10.1016/s0968-0896(01)00397-2

  日期：2002.5

  The synthesis and biological activity of novel 1-phenylsulfonyl-4- phenylsulfonylaminopyrrolidine analogues are described. All compounds were produced through modification of the substituent formally corresponding to the 1,3-dioxane ring system and the omega-octenol side chain of thromboxane A(2) (TXA(2)), in reference to the structure of Daltroban. Several compounds were found to be potent TXA(2) receptor antagonists. Compound 51a was the most effective inhibitor of 9.11-epoxymethano PGH(2) (U-46619)-induced rat aortic strip contraction (IC50 = 0.48 nM). (C) 2002 Elsevier Science Ltd. All rights reserved.
• Indolizin derivatives, process for their preparation and pharmaceutical composition containing them
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0519353B1

  公开（公告）日：2000-08-16
• US5334716A
  申请人：——

  公开号：US5334716A

  公开（公告）日：1994-08-02
• Chemical stability of a prostacyclin analog due to the absence of intramolecular catalysis
  作者：Nils Aake Bergman、Torbjoern Halvarsson

  DOI：10.1021/jo00246a027

  日期：1988.5
• Synthetic Analogues of 15,15-Acetals of Prostaglandin F2α and E2
  作者：Václav Kozmík、Jaroslav Paleček

  DOI：10.1135/cccc19942533

  日期：——

  Two series of 15,15-ethyleneacetals of PG F_2α and PG E₂ modified both in the α- and ω-chains were prepared with a view to find more stable and efficient analogues of this type. The synthesis of the analogues starting from the easily available (±)-[(3aα,4α,5β,6aα)]-5-(1,1'-biphenylyl-4-carbonyloxy)-4-formylhexahydro-2H-cyclopenta[b]furan-2-one, the so-called Corey aldehyde I, was based on conventional procedures, some of which were modified to achieve the optimum yields.

  两个系列的15,15-乙烯基乙醚类似物，分别对PG F_2α和PG E₂的α-和ω-链进行了改性，旨在寻找更稳定和高效的类似物。这些类似物的合成是从易得的(±)-[(3aα,4α,5β,6aα)]-5-(1,1'-联苯基-4-羰基氧基)-4-甲醛基六氢-2H-环戊[b]呋喃-2-酮（称为Corey醛I）开始的，基于常规程序，其中一些被改进以实现最优收率。