[4-(5-Methyl-1H-benzimidazol-2-yl)cyclohexyl]-methylamine | 933682-43-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: [4-(5-Methyl-1H-benzimidazol-2-yl)cyclohexyl]-methylamine
• 英文别名: [4-(6-methyl-1H-benzimidazol-2-yl)cyclohexyl]methanamine
• CAS: 933682-43-0
• 化学式: C₁₅H₂₁N₃
• mdl: MFCD09971891
• 分子量: 243.35
• InChiKey: HVMIDSJYEROFEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.533
• 拓扑面积：
  54.7
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为产物：
  描述：

  3,4-二氨基甲苯 、 凝血酸 在 盐酸 、 氯化铵 作用下， 以 乙醇 为溶剂， 以70 %的产率得到[4-(5-Methyl-1H-benzimidazol-2-yl)cyclohexyl]-methylamine
  参考文献：
  名称：

  Synthesis, Characterization and Antioxidant Evaluation of Tranexamic Acid-derived Benzimidazole, Azomethines, and Oxazolidine

  摘要：

  This work includes the synthesis of heterocyclic compounds and azomethines starting from tranexamic acid. The benzimidazole C2 was prepared by mixing equal molar amounts of tranexamic acid with 4-methyl-o-phenylenediamine). Compounds C13-C18 were prepared by the reaction of tranexamic acid with the aromatic aldehydes. The oxazolidine (C19) was synthesized from the reaction of the compound C13 with hydroxyacetic acid. The synthesized compounds were identified by physical properties such as melting point, color change, and spectral data (Fourier transform infrared and mass). The effectiveness of the compounds C2, C13, C15, C17, and C19 was estimated as antioxidants outside the body (in vitro) and by three methods, namely, reducing power assay, scavenging of hydrogen peroxide, and phosphomolybdenum method.. KEYWORDS :Antioxidant, Azomethine, Benzimidazole, Oxazolidine, Tranexamic acid.

  DOI：

  10.59467/ijhc.2024.34.99

文献信息

• Synthesis, Characterization and Antioxidant Evaluation of Tranexamic Acid-derived Benzimidazole, Azomethines, and Oxazolidine
  作者：Zainab Hashim Mohammad、Rafah Razooq Hameed Al-Samarrai、Malath Khalaf Rasheed

  DOI：10.59467/ijhc.2024.34.99

  日期：2024.3

  This work includes the synthesis of heterocyclic compounds and azomethines starting from tranexamic acid. The benzimidazole C2 was prepared by mixing equal molar amounts of tranexamic acid with 4-methyl-o-phenylenediamine). Compounds C13-C18 were prepared by the reaction of tranexamic acid with the aromatic aldehydes. The oxazolidine (C19) was synthesized from the reaction of the compound C13 with hydroxyacetic acid. The synthesized compounds were identified by physical properties such as melting point, color change, and spectral data (Fourier transform infrared and mass). The effectiveness of the compounds C2, C13, C15, C17, and C19 was estimated as antioxidants outside the body (in vitro) and by three methods, namely, reducing power assay, scavenging of hydrogen peroxide, and phosphomolybdenum method.. KEYWORDS :Antioxidant, Azomethine, Benzimidazole, Oxazolidine, Tranexamic acid.