3-(3-环戊氧基-4-甲氧基苯基)戊二酸 | 172970-89-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 中文名称: 3-(3-环戊氧基-4-甲氧基苯基)戊二酸
• 英文名称: 3-(3-cyclopentyloxy-4-methoxyphenyl)pentanedioic acid
• 英文别名: 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-carboxymethylpropanoic acid
• CAS: 172970-89-7
• 化学式: C₁₇H₂₂O₆
• 分子量: 322.358
• InChiKey: WIIJIPAYKBVRPE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  93.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-(3-环戊氧基-4-甲氧基苯基)戊二酸 在 乙酸酐 作用下， 反应 0.5h， 以93%的产率得到4-(3-cyclopentyloxy-4-methoxyphenyl)dihydropyran-2,6-dione
  参考文献：
  名称：

  A simple enantioselective route toward (R)- and (S)-Rolipram via anhydride desymmetrization

  摘要：

  A highly enantioselective metal-free synthesis of both enantiomers of Rolipram is reported. The key stereoinductive step is a cinchona alkaloid catalyzed opening of a cyclic anhydride prepared from isovanillin, where both enantiomers are available using the same chiral catalyst in two protocols. An extended one-pot Curtius sequence provides the lactam directly from the desymmetrization product after enrichment in high yield and excellent ee. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.01.009
• 作为产物：
  描述：

  3-环戊氧-4-甲氧基苯甲醛 在 哌啶 、 水 、 potassium hydroxide 作用下， 以 乙醇 为溶剂， 反应 144.0h， 生成 3-(3-环戊氧基-4-甲氧基苯基)戊二酸
  参考文献：
  名称：

  A simple enantioselective route toward (R)- and (S)-Rolipram via anhydride desymmetrization

  摘要：

  A highly enantioselective metal-free synthesis of both enantiomers of Rolipram is reported. The key stereoinductive step is a cinchona alkaloid catalyzed opening of a cyclic anhydride prepared from isovanillin, where both enantiomers are available using the same chiral catalyst in two protocols. An extended one-pot Curtius sequence provides the lactam directly from the desymmetrization product after enrichment in high yield and excellent ee. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2013.01.009

文献信息

• Piperidine derivatives and drugs containing these derivatives as active ingredient
  申请人：——

  公开号：US20040044036A1

  公开（公告）日：2004-03-04

  Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): 1 Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is useful for preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, bone fracture, obesity, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia and the like.

  Piperidine衍生物由公式(I)代表，或其无毒盐（其中符号在描述中定义）：由于公式(I)代表的化合物具有PDE4抑制活性，因此对于预防和/或治疗炎症性疾病、糖尿病、过敏性疾病、自身免疫疾病、骨质疏松症、骨折、肥胖症、抑郁症、帕金森病、痴呆症、缺血再灌注损伤、白血病等疾病是有用的。
• Piperidine derivatives and agent comprising the derivative as active ingredient
  申请人：Nakai Hisao

  公开号：US20060189656A1

  公开（公告）日：2006-08-24

  Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is useful for preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, bone fracture, obesity, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia and the like.

  式(I)所代表的吡啶衍生物或其无毒盐（其中符号在描述中定义）：由于式(I)所代表的化合物具有PDE4抑制活性，因此对于预防和/或治疗炎症性疾病、糖尿病、过敏性疾病、自身免疫性疾病、骨质疏松症、骨折、肥胖症、抑郁症、帕金森病、痴呆症、缺血再灌注损伤、白血病等疾病具有用处。
• PIPERIDINE DERIVATIVES AND DRUGS CONTAINING THESE DERIVATIVES AS THE ACTIVE INGREDIENT
  申请人：ONO PHARMACEUTICAL CO., LTD.

  公开号：EP1308440A1

  公开（公告）日：2003-05-07

  Piperidine derivatives represented by formula (I) or nontoxic salts thereof (wherein symbols are defined in the description): Since the compound represented by formula (I) has a PDE4 inhibitory activity, it is useful for preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, osteoporosis, bone fracture, obesity, depression, Parkinson's disease, dementia, ischemia-reperfusion injury, leukemia and the like.

  式 (I) 所代表的哌啶衍生物或其无毒盐（其中符号在描述中定义）： 由于式（I）代表的化合物具有 PDE4 抑制活性，因此可用于预防和/或治疗炎症性疾病、糖尿病、过敏性疾病、自身免疫性疾病、骨质疏松症、骨折、肥胖症、抑郁症、帕金森病、痴呆症、缺血再灌注损伤、白血病等。
• N-ACYL SUBSTITUTED PHENYL PIPERIDINES AS BRONCHODILATORS AND ANTI-INFLAMMATORY AGENTS
  申请人：AMERICAN HOME PRODUCTS CORPORATION

  公开号：EP0696276A1

  公开（公告）日：1996-02-14
• US5459151A
  申请人：——

  公开号：US5459151A

  公开（公告）日：1995-10-17