6-chloro-2-methylchromone-8-carboxaldehyde | 365431-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-chloro-2-methylchromone-8-carboxaldehyde
• 英文别名: 6-Chloro-2-methyl-4-oxochromene-8-carbaldehyde
• CAS: 365431-31-8
• 化学式: C₁₁H₇ClO₃
• 分子量: 222.628
• InChiKey: PFAZBZFCLJNGRL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-chloro-2-methylchromone-8-carboxaldehyde 在 potassium permanganate 、 magnesium sulfate 作用下， 以 丙酮 为溶剂， 反应 3.0h， 以38%的产率得到6-chloro-2-methylchromone-8-carboxylic acid
  参考文献：
  名称：

  SYNTHESIS OF 2-METHYLCHROMONE-8-ACETIC ACIDS AND 2-METHYLCHROMONE-8-CARBOXYLIC ACIDS

  摘要：

  2-Hydroxy-3-allylacetophenones on Claisen condensation with EtOAc/Na gave intermediate diketone, followed by cyclization in AcOH/HCl gave 8-allyl/-1-propenylchromones. which on ozonolysis gave X-acetaldehydes or 8-carboxaldehydes. The above aldehydes on oxidation with KMnO4 furnished corresponding 8-acetic acids and 8-carboxylic acids.

  DOI：

  10.1081/scc-100104068
• 作为产物：
  描述：

  2-hydroxy-3-allyl-5-chloroacetophenone 在 盐酸 、 sodium 作用下， 以 溶剂黄146 为溶剂， 反应 6.0h， 生成 6-chloro-2-methylchromone-8-carboxaldehyde
  参考文献：
  名称：

  SYNTHESIS OF 2-METHYLCHROMONE-8-ACETIC ACIDS AND 2-METHYLCHROMONE-8-CARBOXYLIC ACIDS

  摘要：

  2-Hydroxy-3-allylacetophenones on Claisen condensation with EtOAc/Na gave intermediate diketone, followed by cyclization in AcOH/HCl gave 8-allyl/-1-propenylchromones. which on ozonolysis gave X-acetaldehydes or 8-carboxaldehydes. The above aldehydes on oxidation with KMnO4 furnished corresponding 8-acetic acids and 8-carboxylic acids.

  DOI：

  10.1081/scc-100104068

文献信息

• SYNTHESIS OF 2-METHYLCHROMONE-8-ACETIC ACIDS AND 2-METHYLCHROMONE-8-CARBOXYLIC ACIDS
  作者：S. G. Jagadeesh、G. L. David Krupadanam、G. Srimannarayana

  DOI：10.1081/scc-100104068

  日期：2001.1

  2-Hydroxy-3-allylacetophenones on Claisen condensation with EtOAc/Na gave intermediate diketone, followed by cyclization in AcOH/HCl gave 8-allyl/-1-propenylchromones. which on ozonolysis gave X-acetaldehydes or 8-carboxaldehydes. The above aldehydes on oxidation with KMnO4 furnished corresponding 8-acetic acids and 8-carboxylic acids.