3-(3-羟基-苯基)-丙醛 | 26172-10-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 3-(3-羟基-苯基)-丙醛
• 英文名称: 3-(3-hydroxyphenyl)propanal
• CAS: 26172-10-1
• 化学式: C₉H₁₀O₂
• 分子量: 150.177
• InChiKey: AMQRNDIFPLIQBP-UHFFFAOYSA-N

物化性质

• 沸点：
  278.5±15.0 °C(Predicted)
• 密度：
  1.116±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2912499000

反应信息

• 作为反应物：
  描述：

  3-(3-羟基-苯基)-丙醛 、 在 sodium cyanoborohydride 、 溶剂黄146 作用下， 生成
  参考文献：
  名称：

  Anhydrolide Macrolides. 2. Synthesis and Antibacterial Activity of 2,3-Anhydro-6-O-methyl 11,12-Carbazate Erythromycin A Analogues

  摘要：

  A series of 3-descladinosyl-2,3-anhydro-6-O-methylerythromycin A 11,12-cyclic carbazate analogues was prepared and evaluated for antibacterial activity. These 2,3-anhydro macrolides were found to be potent antibacterial agents in vitro against macrolide-susceptible organisms including Staphylococcus aureus 6538P, Streptococcus pyogenes EES61, and Streptococcus pneumoniae ATCC6303. These compounds were also very active against some organisms that show macrolide resistance (S. aureus A5177, S. pyogenes PIU2584, and S. pneumoniae 5649). The compounds generally showed poor activity against organisms with constitutive MLS resistance. Selected compounds were evaluated in vivo in mouse protection studies. Although most of the compounds tested in vivo showed poor efficacy, two compounds, 38 and 57, were more active than clarithromycin against S. pneumoniae ATCC6303.

  DOI：

  10.1021/jm970548p
• 作为产物：
  描述：

  3-(3-羟基苯基)丙-2-烯醛 在 Wilkinson's catalyst 氢气 作用下， 生成 3-(3-羟基-苯基)-丙醛
  参考文献：
  名称：

  醌的光诱导反应和相关反应。第六部分 一些带有甲酰基的对苯醌的反应

  摘要：

  甲酰基-1,4-苯醌，1,4-苯醌基乙醛，3-（1,4-苯醌基）丙醛，2-（1,4-苯醌基）-2-甲基丙醛和2-甲基-2-（1）的制备描述了（4-萘醌-2-基）丙醛。用可见光照射这些苯醌在苯中的溶液导致将2，5-二羟基苯甲酸从甲酰基-1，4-苯醌中分离出来，并形成5-羟基香豆素-2-酮和3,4-二氢-接下来的两个醌中的6-羟基香豆素；该系列中的最后两个醌失去甲醛元素，分别生成5-羟基-3-甲基苯并呋喃和5-羟基-3-甲基萘-[1,2- b ]呋喃。没有任何辐射进行得很干净。

  DOI：

  10.1039/j39700000649

文献信息

• WRINKLE-IMPROVING AGENT
  申请人：Shiseido Company, Limited

  公开号：EP1941861A1

  公开（公告）日：2008-07-09

  The invention provides a novel wrinkle-improving agent that has an effect of improving wrinkles, that does not entail problems of safety or pain even when applied to the skin, and that contains a very safe substance as an active component. A discovery was made that N-benzoyl-β-alanine, other specific β-alanine derivatives, and salts thereof have a wrinkle-improving effect, whereby a wrinkle-improving agent containing as an active component one, two, or more types of compounds selected from the group composed of these specific β-alanine derivatives and the salts thereof was developed.

  该发明提供了一种新型的改善皱纹的剂，具有改善皱纹的效果，即使应用于皮肤也不会带来安全或疼痛问题，并且包含一种非常安全的物质作为活性成分。发现N-苯甲酰-β-丙氨酸、其他特定的β-丙氨酸衍生物及其盐具有改善皱纹的效果，因此开发了一种改善皱纹的剂，其活性成分包含从这些特定的β-丙氨酸衍生物及其盐组成的群体中选择的一种、两种或更多种化合物。
• Photoactive Chiral Metal–Organic Frameworks for Light-Driven Asymmetric α-Alkylation of Aldehydes
  作者：Pengyan Wu、Cheng He、Jian Wang、Xiaojun Peng、Xuezhao Li、Yonglin An、Chunying Duan

  DOI：10.1021/ja305367j

  日期：2012.9.12

  α-alkylation. The chiral PYI moieties acted as cooperative organocatalytic active sites to drive the asymmetric catalysis with significant stereoselectivity. Control experiments using the lanthanide-based metal-organic frameworks Ho-TCA and MOF-150, assembled from 4,4',4"-nitrilotribenzoic acid, as catalysts suggested that both the photosensitizer triphenylamine moiety and the chiral organocatalyst D-/L-PYI

  具有多孔和可调性质的手性金属有机骨架（MOF）有望作为非均相不对称催化剂。通过将立体选择性有机催化剂 L-或 D-吡咯烷-2-基咪唑 (PYI) 和三苯胺光氧化还原基团结合到单个框架中，我们开发了两种对映体 MOF，Zn-PYI1 和 Zn-PYI2，以促进不对称 α-烷基化脂肪族醛以多相方式。这些 MOF 中三苯胺部分的强还原激发态引发了光诱导电子转移，为 α-烷基化提供了活性中间体。手性 PYI 部分作为协同有机催化活性位点，以显着的立体选择性驱动不对称催化。使用镧系金属有机骨架 Ho-TCA 和 MOF-150 的对照实验，作为催化剂，光敏剂三苯胺部分和手性有机催化剂 D-/L-PYI 部分都是光驱动的 α-烷基化反应所必需的。进一步的研究表明，将光催化剂和不对称有机催化剂整合到单个 MOF 中使得对映选择优于简单地将相应的 MOF 与手性加合物混合。MOF 易于获得、优异的立体选择
• 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles
  申请人：Tsubouchi Hidetsugu

  公开号：US20060094767A1

  公开（公告）日：2006-05-04

  The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula: wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group —OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and —(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H): wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis , multi-drug-resistant Mycobacterium tuberculosis , and atypical acid-fast bacteria.

  本发明提供了一种2,3-二氢-6-硝基咪唑并[2,1-b]噁唑化合物，其通式如下：其中，R1代表氢原子或C1-C6烷基，n代表0到6的整数，R2代表—OR3或类似的基团，R3代表氢原子、C1-C6烷基或类似的基团，或者R1和—(CH2)nR2可以通过相邻的碳原子通过氮原子结合在一起形成一个螺环，其通式为（H）：其中，R41为氢、C1-C6烷基或类似的基团。该化合物对结核分枝杆菌、多药耐药结核分枝杆菌和非典型酸性快速细菌具有优异的杀菌作用。
• Parakeratosis inhibitor, pore -shrinking agent and external compositon for skin
  申请人：Kaminuma Mikiko

  公开号：US20120232111A1

  公开（公告）日：2012-09-13

  The invention provides a parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent that has a function such as parakeratosis inhibition, pore shrinkage, or rough skin—inhibition/abatement, poses no safety problems such as sensory irritation, and is very safe, and further provides an external composition for skin to which a compound having the above-mentioned function has been added. The parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent comprises one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof. The external composition for skin comprises the one or more compounds selected from the group consisting of β-alanine derivatives and salts thereof as the above-mentioned parakeratosis inhibitor, pore-shrinking agent, or rough skin preventing/ameliorating agent.

  本发明提供了一种角化过度抑制剂、毛孔收缩剂或粗糙肌肤预防/改善剂，具有诸如角化过度抑制、毛孔收缩或粗糙肌肤抑制/减轻等功能，不会引起感觉刺激等安全问题，非常安全，还提供了一种外用皮肤组成物，其中添加了具有上述功能的化合物。该角化过度抑制剂、毛孔收缩剂或粗糙肌肤预防/改善剂包括从β-丙氨酸衍生物和其盐的群组中选择的一种或多种化合物。该外用皮肤组成物包括上述β-丙氨酸衍生物和其盐中的一种或多种作为上述角化过度抑制剂、毛孔收缩剂或粗糙肌肤预防/改善剂。
• PESTICIDAL FLAVOBACTERIUM STRAIN AND BIOACTIVE COMPOSITIONS METABOLITES AND USES
  申请人：Marrone Bio Innovations, Inc.

  公开号：US20150031534A1

  公开（公告）日：2015-01-29

  Provided is a pesticidal Flavobacterium strain and bioactive compositions and metabolites derived therefrom as well as their methods of use for controlling pests.

  提供了一种杀虫的黄杆菌菌株及其衍生的生物活性组分和代谢产物，以及它们的使用方法，用于控制害虫。