4-(4'-oxopentyl)pyridine | 90874-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-(4'-oxopentyl)pyridine
• 英文别名: 5-pyridin-4-ylpentan-2-one
• CAS: 90874-89-8
• 化学式: C₁₀H₁₃NO
• 分子量: 163.219
• InChiKey: JFQUYILVPYKTAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-乙烯基吡啶 在 盐酸 、 水 、 sodium 作用下， 生成 4-(4'-oxopentyl)pyridine
  参考文献：
  名称：

  Pyridylethylation of Active Hydrogen Compounds. VI. Reactions of Ketones, Alkylpyridines, and Alkylquinolines with 2- and 4-Vinylpyridine^1,2,3

  摘要：

  DOI：

  10.1021/jo01354a012

文献信息

• Scalable, Electrochemical Oxidation of Unactivated C–H Bonds
  作者：Yu Kawamata、Ming Yan、Zhiqing Liu、Deng-Hui Bao、Jinshan Chen、Jeremy T. Starr、Phil S. Baran

  DOI：10.1021/jacs.7b03539

  日期：2017.6.7

  A practical electrochemical oxidation of unactivated C–H bonds is presented. This reaction utilizes a simple redox mediator, quinuclidine, with inexpensive carbon and nickel electrodes to selectively functionalize “deep-seated” methylene and methine moieties. The process exhibits a broad scope and good functional group compatibility. The scalability, as illustrated by a 50 g scale oxidation of sclareolide

  介绍了未活化的 C-H 键的实际电化学氧化。该反应利用简单的氧化还原介质奎宁环和廉价的碳和镍电极选择性地功能化“深层”亚甲基和次甲基部分。该工艺表现出广泛的范围和良好的官能团兼容性。可扩展性，如紫苏内酯 50 克规模氧化所示，预示着立即和广泛采用。
• Remote Oxidation of Aliphatic C–H Bonds in Nitrogen-Containing Molecules
  作者：Jennifer M. Howell、Kaibo Feng、Joseph R. Clark、Louis J. Trzepkowski、M. Christina White

  DOI：10.1021/jacs.5b10299

  日期：2015.11.25

  Nitrogen heterocycles are ubiquitous in natural products and pharmaceuticals. Herein, we disclose a nitrogen complexation strategy that employs a strong Bronsted acid (HBF4) or an azaphilic Lewis acid (BF3) to enable remote, non-directed C(sp(3))-H oxidations of tertiary, secondary, and primary amine- and pyridine-containing molecules with tunable iron catalysts. Imides resist oxidation and promote remote functionalization.
• Nikishin, G. I.; Sokova, L. L.; Kapustina, N. I., Doklady Chemistry, 1992, vol. 326, # 1.3, p. 205 - 207
  作者：Nikishin, G. I.、Sokova, L. L.、Kapustina, N. I.

  DOI：——

  日期：——
• Homolytic oxoalkylation of protonatedN-heteroaromatic compounds
  作者：N. I. Kapustina、L. L. Sokova、A. V. Ignatenko、G. I. Nikishin

  DOI：10.1007/bf00698999

  日期：1993.11

  The oxoalkylation of pyridine, 2-methyl-, 4-methyl-, 2,4-dimethyl-, 2,6-dimethyl-pyridines, quinoline, 4-methylquinoline, isoquinoline, and pyrazine with oxoalkyl radicals generated from 1-methylcyclobutanol or 1-methylcyclopentanol under the action of Pb(OAc)4 or Mn(OAc)3 has been carried out. The reaction products are isomers with 2-(6)- and 4-positions of the oxoalkyl group in the N-heteroaromatic ring. The isomer ratios have been determined as a function of the structure of the N-heteroaromatic compound and the reaction conditions.
• ——
  作者：G. I. Nikishin、L. L. Sokova、N. I. Kapustina

  DOI：10.1023/a:1011310511760

  日期：——