(+/-)-2,6-Dimethyl-4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenol | 125404-86-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (+/-)-2,6-Dimethyl-4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenol
• 英文别名: 2,6-Dimethyl-4-tetralin-1-yl-phenol；2,6-dimethyl-4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenol
• CAS: 125404-86-6
• 化学式: C₁₈H₂₀O
• 分子量: 252.356
• InChiKey: GFVMCQKUIJCSAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-苯基丁酸 在 lithium aluminium tetrahydride 、 叔丁基锂 、 四氯化钛 作用下， 以 四氢呋喃 、 二氯甲烷 、 正戊烷 为溶剂， 反应 2.58h， 生成 (+/-)-2,6-Dimethyl-4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenol
  参考文献：
  名称：

  Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

  摘要：

  p-Quinone methides were found to be excellent electrophilic cyclization initiators for the formation of six-membered rings. Cyclizations to form five- and seven-membered rings were also studied. Oxidation of 2,6-disubstituted phenols with Ag2O afforded the corresponding quinone methides. A wide range of cyclization terminators/nucleophiles were found to be effective in the cyclizations, including: allylsilane, beta-keto esters, furan, pyrrole, indole, and a number of alkenes. The yields of the cyclizations were generally high.

  DOI：

  10.1021/jo00100a039

文献信息

• Cationic cyclization reactions initiated by stabilized benzyl cations
  作者：Steven R. Angle、Michael S. Louie

  DOI：10.1016/s0040-4039(00)76185-5

  日期：1989.1

  The in situ generation of stabilized benzyl cations and their subsequent use in cyclization reactions with a monosubstituted benzene, a furan and a β-keto ester terminators is described.

  描述了稳定的苄基阳离子的原位产生及其在与单取代的苯，呋喃和β-酮酸酯终止剂的环化反应中的后续应用。
• Para-quinone methide initiated intramolecular electrophilic substitution reactions
  作者：Steven R. Angle、Michael S. Louie、Heather L. Mattson、Wenjin Yang

  DOI：10.1016/s0040-4039(00)72713-4

  日期：1989.1

  A study on the reactivity of para-quinone methides in intramolecular cyclization reactions is presented. The para-quinone methides were isolated and completely characterized prior to cyclization. A furan, a pyrrole and a mono-alkyl substituted benzene were used as cyclization terminators.

  提出了对-醌甲基化物在分子内环化反应中的反应性的研究。的对位-quinone甲基化物进行分离和前环化完全表征。呋喃，吡咯和单烷基取代的苯用作环化终止剂。
• ANGLE, STEVEN R.;LOUIE, MICHAEL S.;MATTSON, HEATHER L.;YANG, WENJIN, TETRAHEDRON LETT., 30,(1989) N0, C. 1193-1196
  作者：ANGLE, STEVEN R.、LOUIE, MICHAEL S.、MATTSON, HEATHER L.、YANG, WENJIN

  DOI：——

  日期：——
• Angle Steven R., Arnaiz Damian O., Boyce James P., Frutos Rogelio P., Lou+, J. Org. Chem, 59 (1994) N 21, S 6322-6337
  作者：Angle Steven R., Arnaiz Damian O., Boyce James P., Frutos Rogelio P., Lou+

  DOI：——

  日期：——