2-(3,5-dichloro-2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester | 500887-70-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,5-dichloro-2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester
• 英文别名: 2-(3,5-Dichlor-2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoesaeure-methylester；Methyl 2-(3,5-dichloro-2,6-dimethoxy-4-methylbenzoyl)-3,5-dimethoxybenzoate
• CAS: 500887-70-7
• 化学式: C₂₀H₂₀Cl₂O₇
• 分子量: 443.281
• InChiKey: IXSXGTNMTQGRMH-UHFFFAOYSA-N

物化性质

• 沸点：
  591.1±50.0 °C(Predicted)
• 密度：
  1.297±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(3,5-dichloro-2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester 在 硫酸 作用下， 生成 acide dichloro-3,5-hydroxy-2-methoxy-6-methyl-4-benzoique
  参考文献：
  名称：

  Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators

  摘要：

  Purpose: To describe the effects of the combination of several therapies on the pulmonary circulation and cardiac function in a patient with severe pulmonary hypertension.Clinical features: We report the case of a female patient with chronic secondary pulmonary hypertension and cardiac failure who underwent right hemicolectomy under general anesthesia. Insertion of a pulmonary artery catheter before the operation revealed pulmonary artery pressure (PAP) of 55/24 mmHg which was lowered moderately by 40 parts per million (ppm) inhNO, During surgery, the patient presented an episode of atrial fibrillation with a slow, irregular heart rate of 45-50 min(-1) and variable systemic pressure. A dipyridamole DPD (0.2 mg.kg(-1)) bolus stabilized systemic pressure and increased heart rate and cardiac output. However, PAP did not change. Nitroglycerine infusion was started at 10 mg.hr(-1) shortly after the initiation of DPD, The patient responded favourably to combined inhNO, intravenous DPD and NTG therapy with a marked and sustained reduction of PAP and a systemic hemodynamic stability.Conclusion: We conclude that: 1) in combination with inhNO, DPD does not augment the inhNO-induced decrease in PAP; 2) DPD improves the hemodynamic profile and elevates cardiac output; 3) therapeutic combination (inhaled NO, NTG, DPD) has a potent effect an pulmonary pressure in cardiac failure patients.

  DOI：

  10.1007/bf03018946
• 作为产物：
  描述：

  3,5-二氯-2,6-二甲氧基-4-甲基苯甲酸 在 三氯化铝 、 氯化亚砜 、 乙醚 作用下， 生成 2-(3,5-dichloro-2,6-dimethoxy-4-methyl-benzoyl)-3,5-dimethoxy-benzoic acid methyl ester
  参考文献：
  名称：

  Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators

  摘要：

  Purpose: To describe the effects of the combination of several therapies on the pulmonary circulation and cardiac function in a patient with severe pulmonary hypertension.Clinical features: We report the case of a female patient with chronic secondary pulmonary hypertension and cardiac failure who underwent right hemicolectomy under general anesthesia. Insertion of a pulmonary artery catheter before the operation revealed pulmonary artery pressure (PAP) of 55/24 mmHg which was lowered moderately by 40 parts per million (ppm) inhNO, During surgery, the patient presented an episode of atrial fibrillation with a slow, irregular heart rate of 45-50 min(-1) and variable systemic pressure. A dipyridamole DPD (0.2 mg.kg(-1)) bolus stabilized systemic pressure and increased heart rate and cardiac output. However, PAP did not change. Nitroglycerine infusion was started at 10 mg.hr(-1) shortly after the initiation of DPD, The patient responded favourably to combined inhNO, intravenous DPD and NTG therapy with a marked and sustained reduction of PAP and a systemic hemodynamic stability.Conclusion: We conclude that: 1) in combination with inhNO, DPD does not augment the inhNO-induced decrease in PAP; 2) DPD improves the hemodynamic profile and elevates cardiac output; 3) therapeutic combination (inhaled NO, NTG, DPD) has a potent effect an pulmonary pressure in cardiac failure patients.

  DOI：

  10.1007/bf03018946

文献信息

• Inner core’s seismic anisotropy is related to its rotation
  作者：Bin Liu、Qunshan Zhang、Baoshan Wang、Rongshan Fu、H. Kern、T. Popp

  DOI：10.1007/bf02886184

  日期：2000.4

  The inner core has a differential rotation relative to the crust and mantle, the relative linear velocity between the solid inner core and the molten outer core is the biggest at the equator and zero at pole area, As a result, the inner core grows faster at the equator than at the pole area. The gravitational force drives the material flow from the equator to the pole area and makes the inner core remain quasi-orbicular. The corresponding axial symmetric stress field makes c-axes of hexagonal close packed (hcp) iron align with inner core's rotation axis, resulting in observed seismic anisotropy.
• Treatment of pulmonary hypertension during surgery with nitric oxide and vasodilators
  作者：Zu Yi Jiang、Tudor Costachescu、Marc Derouin、Gilbert Blaise

  DOI：10.1007/bf03018946

  日期：2000.6

  Purpose: To describe the effects of the combination of several therapies on the pulmonary circulation and cardiac function in a patient with severe pulmonary hypertension.Clinical features: We report the case of a female patient with chronic secondary pulmonary hypertension and cardiac failure who underwent right hemicolectomy under general anesthesia. Insertion of a pulmonary artery catheter before the operation revealed pulmonary artery pressure (PAP) of 55/24 mmHg which was lowered moderately by 40 parts per million (ppm) inhNO, During surgery, the patient presented an episode of atrial fibrillation with a slow, irregular heart rate of 45-50 min(-1) and variable systemic pressure. A dipyridamole DPD (0.2 mg.kg(-1)) bolus stabilized systemic pressure and increased heart rate and cardiac output. However, PAP did not change. Nitroglycerine infusion was started at 10 mg.hr(-1) shortly after the initiation of DPD, The patient responded favourably to combined inhNO, intravenous DPD and NTG therapy with a marked and sustained reduction of PAP and a systemic hemodynamic stability.Conclusion: We conclude that: 1) in combination with inhNO, DPD does not augment the inhNO-induced decrease in PAP; 2) DPD improves the hemodynamic profile and elevates cardiac output; 3) therapeutic combination (inhaled NO, NTG, DPD) has a potent effect an pulmonary pressure in cardiac failure patients.