2-Bromo-6-[6-[2-[2-[2-[2-[6-(6-bromopyridin-2-yl)pyridin-2-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]pyridin-2-yl]pyridine | 914458-72-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Bromo-6-[6-[2-[2-[2-[2-[6-(6-bromopyridin-2-yl)pyridin-2-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]pyridin-2-yl]pyridine
• 英文别名: 2-bromo-6-[6-[2-[2-[2-[2-[6-(6-bromopyridin-2-yl)pyridin-2-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]pyridin-2-yl]pyridine
• CAS: 914458-72-3
• 化学式: C₂₈H₂₈Br₂N₄O₅
• 分子量: 660.362
• InChiKey: NQXXCJPECJZLQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  39
• 可旋转键数：
  16
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  97.7
• 氢给体数：
  0
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  2-Bromo-6-[6-[2-[2-[2-[2-[6-(6-bromopyridin-2-yl)pyridin-2-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]pyridin-2-yl]pyridine 在 四(三苯基膦)钯 2,6-二叔丁基-4-甲基苯酚 作用下， 以 甲苯 为溶剂， 反应 14.0h， 生成 (2S,5R)-16,19,22,25,28-pentaoxa-38,39,40,41-tetrazahexacyclo[32.3.1.16,10.111,15.129,33.02,5]hentetraconta-1(37),6,8,10(41),11(40),12,14,29,31,33(39),34(38),35-dodecaene
  参考文献：
  名称：

  Synthesis of crownophanes possessing bipyridine moieties: bipyridinocrownophanes exhibiting perfect extractability toward Ag+ ion

  摘要：

  Novel crownophanes with two bipyridine moieties (bipyridinocrownophanes la and 1b) were conveniently prepared by means of intramolecular [2+2] photocycloaddition of vinylbipyridine derivatives. In the liquid-liquid extraction of heavy metal cations, la and 1b exhibited perfect selectivity toward Ag+ with high efficiency. It was found that the ethereal oxygen atoms and the four nitrogen atoms in 1a and 1b acted as ligating sites, according to the high extractability and complexing stability constant for Ag+ compared to those of the corresponding pyridinocrownophanes 4a and 4b. H-1 NMR and ESI-MS analyses suggested that the crownophanes formed a 1:1 complexes with the Ag+ ion. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.005
• 作为产物：
  描述：

  6,6'-二溴-2,2'-联吡啶 、 三缩四乙二醇 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以53%的产率得到2-Bromo-6-[6-[2-[2-[2-[2-[6-(6-bromopyridin-2-yl)pyridin-2-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]pyridin-2-yl]pyridine
  参考文献：
  名称：

  Synthesis of crownophanes possessing bipyridine moieties: bipyridinocrownophanes exhibiting perfect extractability toward Ag+ ion

  摘要：

  Novel crownophanes with two bipyridine moieties (bipyridinocrownophanes la and 1b) were conveniently prepared by means of intramolecular [2+2] photocycloaddition of vinylbipyridine derivatives. In the liquid-liquid extraction of heavy metal cations, la and 1b exhibited perfect selectivity toward Ag+ with high efficiency. It was found that the ethereal oxygen atoms and the four nitrogen atoms in 1a and 1b acted as ligating sites, according to the high extractability and complexing stability constant for Ag+ compared to those of the corresponding pyridinocrownophanes 4a and 4b. H-1 NMR and ESI-MS analyses suggested that the crownophanes formed a 1:1 complexes with the Ag+ ion. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.08.005

文献信息

• Synthesis of crownophanes possessing bipyridine moieties: bipyridinocrownophanes exhibiting perfect extractability toward Ag+ ion
  作者：Seiichi Inokuma、Masahiro Kuramami、Shinji Otsuki、Tetsuyuki Shirakawa、Shi-ichi Kondo、Yosuke Nakamura、Jun Nishimura

  DOI：10.1016/j.tet.2006.08.005

  日期：2006.10

  Novel crownophanes with two bipyridine moieties (bipyridinocrownophanes la and 1b) were conveniently prepared by means of intramolecular [2+2] photocycloaddition of vinylbipyridine derivatives. In the liquid-liquid extraction of heavy metal cations, la and 1b exhibited perfect selectivity toward Ag+ with high efficiency. It was found that the ethereal oxygen atoms and the four nitrogen atoms in 1a and 1b acted as ligating sites, according to the high extractability and complexing stability constant for Ag+ compared to those of the corresponding pyridinocrownophanes 4a and 4b. H-1 NMR and ESI-MS analyses suggested that the crownophanes formed a 1:1 complexes with the Ag+ ion. (c) 2006 Elsevier Ltd. All rights reserved.