1-(2,2-dimethoxyethyl)-1-tosylcyclopentane | 176312-97-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,2-dimethoxyethyl)-1-tosylcyclopentane
• 英文别名: 1-[1-(2,2-dimethoxyethyl)cyclopentyl]sulfonyl-4-methylbenzene
• CAS: 176312-97-3
• 化学式: C₁₆H₂₄O₄S
• 分子量: 312.43
• InChiKey: MMROFRDCYSCGKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.09
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  52.6
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  1-(2,2-dimethoxyethyl)-1-tosylcyclopentane 在 盐酸 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 、 水 、 丙酮 为溶剂， 生成 cyclopentylidenacetaldehyde
  参考文献：
  名称：

  Dilithiated 3-tosylpropanal dimethyl acetal as β,β-acylvinyl dianion or homoenolate dianion equivalent

  摘要：

  3,3-Dilithio-1,1-dimethoxy-3-tosylpropane (6) reacts with mono and dielectrophiles to give dialkylated products 7 and carbocyclic derivatives 8, respectively. Hydrolysis of the acetal function followed by DBU dehydrosulfinylation of these products affords beta,beta-disubstituted propenal derivatives 11 and 12. Reductive desulfonylation of compounds 8g-j provides beta,beta-disubstituted propanal acetals 14.

  DOI：

  10.1016/s0040-4020(96)00072-5
• 作为产物：
  描述：

  1,4-二碘代丁烷 、 1,1-dimethoxy-3-(4-tolylsulfonyl)propane 在 正丁基锂 作用下， 生成 1-(2,2-dimethoxyethyl)-1-tosylcyclopentane 、
  参考文献：
  名称：

  Dilithiated 3-tosylpropanal dimethyl acetal as β,β-acylvinyl dianion or homoenolate dianion equivalent

  摘要：

  3,3-Dilithio-1,1-dimethoxy-3-tosylpropane (6) reacts with mono and dielectrophiles to give dialkylated products 7 and carbocyclic derivatives 8, respectively. Hydrolysis of the acetal function followed by DBU dehydrosulfinylation of these products affords beta,beta-disubstituted propenal derivatives 11 and 12. Reductive desulfonylation of compounds 8g-j provides beta,beta-disubstituted propanal acetals 14.

  DOI：

  10.1016/s0040-4020(96)00072-5

文献信息

• Dilithiated 3-tosylpropanal dimethyl acetal as β,β-acylvinyl dianion or homoenolate dianion equivalent
  作者：Pedro Bonete、Carmen Nájera

  DOI：10.1016/s0040-4020(96)00072-5

  日期：1996.3

  3,3-Dilithio-1,1-dimethoxy-3-tosylpropane (6) reacts with mono and dielectrophiles to give dialkylated products 7 and carbocyclic derivatives 8, respectively. Hydrolysis of the acetal function followed by DBU dehydrosulfinylation of these products affords beta,beta-disubstituted propenal derivatives 11 and 12. Reductive desulfonylation of compounds 8g-j provides beta,beta-disubstituted propanal acetals 14.