sodium N-methylanilide | 5000-15-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: sodium N-methylanilide
• 英文别名: sodium;methyl(phenyl)azanide
• CAS: 5000-15-7
• 化学式: C₇H₈N*Na
• 分子量: 129.137
• InChiKey: XLFNOLLLIRCFNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.67
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-溴乙酰乙酸乙酯 、 sodium N-methylanilide 生成 4-(N-甲基苯胺基)-3-氧代丁酸乙酯
  参考文献：
  名称：

  合成4-取代的乙酰乙酸酯的方法

  摘要：

  可以用氢化钠将4-溴-3-氧代丁酸乙酯转化为烯醇盐，然后可以在4-碳原子上进行亲核取代。

  DOI：

  10.1039/c39770000932
• 作为试剂：
  描述：

  7,7'-p-phenylenedioxy-di-heptanenitrile 在 硫酸 、 sodium N-methylanilide 、 苯 作用下， 生成 1,15-dioxa-[15]paracyclophan-8-one
  参考文献：
  名称：

  Ziegler; Luettringhaus, Justus Liebigs Annalen der Chemie, 1934, vol. 511, p. 1,11

  摘要：

  DOI：

文献信息

• Nickel-Catalyzed Amination of Aryl Thioethers: A Combined Synthetic and Mechanistic Study
  作者：Alessandro Bismuto、Tristan Delcaillau、Patrick Müller、Bill Morandi

  DOI：10.1021/acscatal.0c00393

  日期：2020.4.17

  and kinetically competent catalysts for this transformation. The fleeting transmetalation intermediate has been successfully synthesized through an alternative synthetic organometallic pathway at lower temperature, allowing for in situ NMR study of the C–N bond reductive elimination step. This study addresses key factors governing the mechanism of the nickel-catalyzed Buchwald–Hartwig amination process

  在本文中，我们报道了镍1,2,2-双（二环己基膦基）乙烷（dcype）配合物用于芳基硫醚的Buchwald-Hartwig催化胺化。该方案显示了在催化条件下可耐受的各种不同官能团的广泛适用性。广泛的有机金属和动力学研究支持这种转化的镍（0）-镍（II）途径，并揭示了氧化加成配合物是催化循环的静止状态。已证明所有分离出的中间体都是这种转化的催化和动力学催化剂。通过在较低的温度下通过另一种合成的有机金属途径，已经成功合成了短暂的重金属化中间体，从而可以对C–N键的还原消除步骤进行原位NMR研究。
• Processes and compounds for the preparation of substituted naphthylindole derivatives
  申请人：Dragan A. Vladimir

  公开号：US20060183917A1

  公开（公告）日：2006-08-17

  The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.

  本发明提供了制备取代萘基吲哚衍生物的方法，可用作纤维蛋白溶酶原激活物抑制剂-1（PAI-1）的抑制剂。在本发明的某些实施例中，该方法涉及反应，包括Oppenauer氧化反应，Fischer吲哚合成反应，甲醚裂解反应或将取代甲基四唑与取代萘酚偶联反应的一种或多种。
• PROCESSES AND COMPOUNDS FOR THE PREPARATION OF SUBSTITUTED NAPHTHYLINDOLE DERIVATIVES
  申请人：DRAGAN A. Vladimir

  公开号：US20080071091A1

  公开（公告）日：2008-03-20

  The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1 (PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.

  本发明提供了制备取代萘基吲哚衍生物的方法，可以用作纤溶酶原激活物抑制剂-1（PAI-1）的抑制剂。在本发明的某些实施例中，该方法包括反应，其中包括Oppenauer氧化、Fischer吲哚合成、甲醚裂解或将取代甲基四唑与取代萘酚偶联的一个或多个。
• PROCESS FOR PRODUCING 2-($g(v)-ALKOXYCARBONYLALKANOYL)-4-BUTANOLIDE AND LONG-CHAIN $g(v)-HYDROXY CARBOXYLIC ACID
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP0794182A1

  公开（公告）日：1997-09-10

  2-(ω-alkoxycarbonyl alkanoyl)-4-butanolide can be produced unexpectedly with a high selectivity and yield through condensation reaction of γ-butyrolactone with a highly available, loω-price dicarboxylate as represented by the following general formula:         ROOC(CH2)nCOOR (where n denotes an integer of 7-13, and R denotes an alkyl group or an alkenyl group). Furthermore, a long-chain ω-hydroxycarboxylic acid can be produced by subjecting 2-(ω-alkoxycarbonyl alkanoyl)-4-butanolide to hydrolysis and decarboxylation and reducing the carbonyl groups in the resultant product into methylene groups.

  通过γ-丁内酯与以下通式所代表的高可得性、低ω价二羧酸盐的缩合反应，可以意外地以高选择性和高产率生产出 2-(ω-烷氧羰基烷酰基)-4-丁内酯： ROOC(CH2)nCOOR (其中 n 表示 7-13 的整数，R 表示烷基或烯基）。此外，将 2-(ω-烷氧羰基烷酰基)-4-丁内酯进行水解和脱羧反应，并将所得产物中的羰基还原成亚甲基，可制得长链ω-羟基羧酸。
• Conversion of 7-methoxy-3,4-dihydro-2H-1-benzopyran-2-one into the corresponding dimethyl ortho ester
  作者：David G. Bourke、David J. Collins

  DOI：10.1016/s0040-4020(97)00007-0

  日期：1997.3

  7-Methoxy-3,4-dihydro-2H-1-benzopyran-2-one 2 was converted into 3-(2'-tert-butyldimethylsilyloxy-4'-methoxyphenyl)-N-Methyl-N-phenylpropanamide 25 and reaction of this with methyl trifluoromethanesulfonate, followed by reaction with sodium methoxide, gave 2,2,7-trimethoxy-2H-1-benzopyran 1a in 55% overall yield from 25. A similar methylation/methoxide sequence using 3-(2'-benzyloxy-4'-methoxyphenyl)-N-methyl-N-phenylpropanamide 18 gave a mixture which contained trimethyl 3-(2'-benzyloxy-4'-methoxyphenyl)orthopropanoate 20a and reaction of this mixture with a solution of sodium in tert-butanol gave a product in which 2,2,7-trimethoxy-2H-1-benzopyran 1a was detected, but not isolable. (C) 1997 Elsevier Science Ltd.