N-methylammonium p-toluenesulfonate | 2840-20-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methylammonium p-toluenesulfonate
• 英文别名: monomethylammonium p-toluenesulfonate；methylammonium tosylate；methylamine tolylsulfonate；Toluolsulfonsaeure-(4)-Methylamin-Salz；Toluol-4-sulfonsaeure; Salz des Methylamins；toluene-4-sulfonic acid ; methylamine salt；Toluol-4-sulfonsaeure; Methylamin-Salz；methyl-ammonium p-toluenesulfonate；methylazanium;4-methylbenzenesulfonate
• CAS: 2840-20-2
• 化学式: CH₅N*C₇H₈O₃S
• 分子量: 203.262
• InChiKey: PTFDTQDDWWQYMG-UHFFFAOYSA-N

物化性质

• 熔点：
  145.5-145.7 °C

计算性质

• 辛醇/水分配系数(LogP)：
  -0.24
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  93.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-5-(3-吡啶基)四氢-2-呋喃酮 、 N-methylammonium p-toluenesulfonate 在 盐酸 作用下， 反应 12.0h， 生成 1-甲基-5-(3-吡啶基)-2-吡咯烷酮
  参考文献：
  名称：

  一种人工合成尼古丁的制备方法

  摘要：

  本发明公开了一种人工合成尼古丁的制备方法，属于化学合成技术领域。本发明提供的消旋体(±)‑(R,S)‑尼古丁及天然光学活性体(‑)‑(S)‑尼古丁的合成方法是通过采用烟酸酯与琥珀酸二酯或N‑烷基琥珀酰亚胺作为初始原料，其可以克服现有人工合成尼古丁技术所存在的规模化生产困难、成本昂贵等诸多缺陷。具体的，本发明提供的消旋体(±)‑(R,S)‑尼古丁及天然光学活性体(‑)‑(S)‑尼古丁的合成方法所采用的初始原料是很容易获得的，其制备工艺简单，成本低廉，所制得的尼古丁不含有任何有害的其它烟草化合物，并且适合于工业规模化生产。

  公开号：

  CN110256403B
• 作为产物：
  描述：

  甲苯 在 硫酸 、 水 作用下， 生成 N-methylammonium p-toluenesulfonate
  参考文献：
  名称：

  Norton; Otten, American Chemical Journal, 1888, vol. 10, p. 144

  摘要：

  DOI：

文献信息

• Synthesis of Alkylammonium Tosylates with Poly{[4‐Hydroxy(Tosyloxy)Iodo]Styrene}
  作者：Shi Juan Liu、Ji Zhen Zhang、Guan Rong Tian、Ping Liu

  DOI：10.1081/scc-200050954

  日期：2005.3

  Abstract Several primary carboxamides (RCONH2) were converted to the corresponding alkylammonium tosylates (RN+H3 −OTs) with poly[4‐hydroxy(tosyloxy)iodo]styrene} (PSHTIB) in yields ranging from 60% to 90%.

  摘要 几种初级甲酰胺（RCONH2）与聚[4-羟基（甲苯磺酰氧基）碘]苯乙烯}（PSHTIB）转化为相应的甲苯磺酸烷基铵（RN+H3-OTs），产率从60%到90%不等。
• New Upper Rim Pyridine-Bridged Calix[4]arenes:  Synthesis and Complexation Properties toward Neutral Molecules and Ammonium Ions in Organic Media
  作者：Arturo Arduini、William M. MGregor、Andrea Pochini、Andrea Secchi、Franco Ugozzoli、Rocco Ungaro

  DOI：10.1021/jo960937b

  日期：1996.1.1

  of calix[4]arenes, diametrically bridged at the upper rim with pyridino systems, has been synthesized. The shape, rigidity, and chemical structure of the bridge influence the host-guest complexation properties of these systems in solution toward several neutral molecules having acidic C-H bonds. Additionally, selective complexation of methylammonium tosylate in comparison with other ammonium salts has

  合成了一系列新的杯芳烃[4]芳烃，它们在上缘与吡啶基体系径向连接。桥的形状，刚性和化学结构影响这些体系在溶液中朝着几个带有酸性CH键的中性分子的主客体络合特性。另外，已经观察到甲苯磺酸甲基铵与其他铵盐的选择性络合，并且该络合物的强度通过杯芳烃主体的吡啶部分上的p-取代基的电子给体能力而增强。主体5与丙二腈和硝基甲烷的内配合物的X射线晶体结构已得到解析，证实了与桥的硬氧和氮原子以及杯芳烃的软芳环形成特定的CH键。
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY PURE 1-SUBSTITUTED-3-AMINOALCOHOLS
  申请人：Brieden Walter

  公开号：US20120316350A1

  公开（公告）日：2012-12-13

  A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (1a), (1b): wherein R 1 is C 6-20 -aryl or C 4-12 -heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, R 2 is C 1-4 -alkyl or C 6-20 -aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, and wherein R 3 is selected from the group consisting of C 1-18 -alkyl, C 6-20 -cycloalkyl, C 6-20 -aryl and C 7-20 -aralkyl residues; including a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, said organic solvent which can include water to provide N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R 1 , R 2 and R 3 are as defined above, and b) asymmetrically hydrogenating.

  一种制备式(1a)、(1b)的N-单取代β-氨基醇磺酸盐的方法，其中R1为C6-20芳基或C4-12杂芳基，每个芳基可选择性地被一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基取代，R2为C1-4烷基或C6-20芳基，每个芳基可选择性地被一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基取代，而R3从C1-18烷基、C6-20环烷基、C6-20芳基和C7-20芳基烷基残基中选择；包括a)在压力高于1.5巴的条件下，选择性地在有机溶剂中反应甲基酮、一级胺、甲醛和磺酸，所述有机溶剂可包括水，从而提供式(II)的N-单取代β-氨基酮磺酸盐：其中R1、R2和R3如上所定义；b)不对称氢化。
• Process for the Preparation of Enantiomerically Pure 1-Substituted-3-Aminoalcohols
  申请人：Brieden Walter

  公开号：US20090156833A1

  公开（公告）日：2009-06-18

  A process for the preparation of N-monosubstituted β-aminoalcohol sulfonates of formula (Ia), (Ib): wherein R 1 is C 6-20 -aryl or C 4-12 -heteroaryl, each optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups, R 2 is C 1-4 -alkyl or C 6-20 -aryl, each aryl optionally being substituted with one or more halogen atoms and/or one or more C 1-4 -alkyl or C 1-4 -alkoxy groups and wherein R 3 is selected from the group consisting of C 1-18 -alkyl, C 6-20 -cycloalkyl, C 6-20 -aryl and C 7-20 -aralkyl residues. The process has the steps of (a) reacting a methyl ketone, a primary amine, formaldehyde and a sulfonic acid, at a pressure above 1.5 bar, optionally in a organic solvent, the organic solvent optionally containing water, to afford N-monosubstituted β-aminoketone sulfonates of formula (II): wherein R 1 , R 2 and R 3 are as defined above, and (b) asymmetrically hydrogenating. The sulfonates in the presence of a base and a catalyst of a transition metal and a disphosphine ligand, in a polar solvent, optionally in the presence of water.

  一种制备公式（Ia），（Ib）的N-单取代β-氨基醇磺酸盐的方法：其中R1是C6-20芳基或C4-12杂芳基，每个选项可用一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基置换，R2是C1-4烷基或C6-20芳基，每个芳基可用一个或多个卤素原子和/或一个或多个C1-4烷基或C1-4烷氧基置换，其中R3选自由C1-18烷基，C6-20环烷基，C6-20芳基和C7-20芳基烷基残基组成的群。该过程的步骤为：（a）在压力大于1.5巴的情况下，将甲基酮，一级胺，甲醛和磺酸反应，可选地在有机溶剂中，所述有机溶剂可选地包含水，以得到公式（II）的N-单取代β-氨基酮磺酸盐：其中R1，R2和R3如上所述，以及（b）在极性溶剂中，在碱和过渡金属和双膦配体的催化剂存在下，可选地在水的存在下，对磺酸盐进行不对称氢化。
• No-post-cure method of curing polyacrylate polymers
  申请人：Zeon Chemicals USA, Inc.

  公开号：EP0309794A2

  公开（公告）日：1989-04-05

  A no-post-cure method of curing polyacrylates having dual cure sites is accomplished with a two-part curing system or a combined one-part curing system. The two-part curing system consists of one or more metallic acid salts and an ammonium and/or phosphonium quaternary salt. The one-part curing system consists of an ammonium or phosphonium quaternary acid salt. The polyacrylate rubber must have both a halogen and a carboxyl cure site. The method consists of blending the curative with the polyacrylate rubber and heating the resultant com­position until the composition cures. Because the mixed composition is shelf stable, it is not necessary to immediately heat the composition to cure it. The method may optionally include the step of storing the mixed composition until it is desired to cure it.

  使用双组分固化体系或组合式单组分固化体系，可实现具有双重固化位点的聚丙烯酸酯的免后固化方法。双组分固化体系由一种或多种金属酸盐和一种铵和/或鏻季盐组成。单组分固化体系由铵或鏻季酸盐组成。聚丙烯酸酯橡胶必须同时具有卤素和羧基固化位点。该方法包括将固化剂与聚丙烯酸酯橡胶混合，然后加热所得组合物，直至组合物固化。由于混合后的组合物具有货架稳定性，因此无需立即加热组合物使其固化。该方法可选择包括储存混合组合物的步骤，直到需要固化为止。