N¹-(4-methoxybenzoyl)-N²-(2,6-dimethylphenyl)-hydrazine | 75601-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹-(4-methoxybenzoyl)-N²-(2,6-dimethylphenyl)-hydrazine
• 英文别名: N'-(2,6-dimethylphenyl)-4-methoxybenzohydrazide
• CAS: 75601-10-4
• 化学式: C₁₆H₁₈N₂O₂
• 分子量: 270.331
• InChiKey: FCCKQPUBFXGZAS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  50.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N¹-(4-methoxybenzoyl)-N²-(2,6-dimethylphenyl)-hydrazine 以10%的产率得到
  参考文献：
  名称：

  FUSCO R.; SANNICOLO F., J. ORG. CHEM., 1981, 46, NO 1, 83-89

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲氧基苯甲酰氯 、 2,6-二甲基苯肼 在 三乙胺 作用下， 以 氯仿 为溶剂， 反应 0.5h， 以70%的产率得到N¹-(4-methoxybenzoyl)-N²-(2,6-dimethylphenyl)-hydrazine
  参考文献：
  名称：

  Rearrangement of arylhydrazones of aromatic and arylaliphatic carbonyl compounds to biphenyl derivatives. 3

  摘要：

  DOI：

  10.1021/jo00314a018

文献信息

• Identification and Structure–Activity Relationships of Diarylhydrazides as Novel Potent and Selective Human Enterovirus Inhibitors
  作者：Xin Han、Ningyuan Sun、Haoming Wu、Deyin Guo、Po Tien、Chune Dong、Shuwen Wu、Hai-Bing Zhou

  DOI：10.1021/acs.jmedchem.5b01803

  日期：2016.3.10

  Enterovirus 71 (EV71) plays an important role in hand-foot-and-mouth disease. In this study, a series of diarylhydrazide analogues was synthesized, and the systematic exploration of SAP. led to potent enterovirus inhibitors, of which compound 15 exhibits significant improvements in inhibition potency with an EC50 value of 0.02 mu M against EV71. It is very interesting that this class of diarylhydrazides exhibits activities against a series of human enteroviruses at the picomolar level, including EV71 and Coxsackieviruses B1 (CVB1), CVB2, CVB3, CVB4, CVB5, and CVB6 (EC50 as low as 0.5 nM). Compared with the reference antienterovirus drug 1 (enviroxime) and known inhibitor 5 (WIN 51711), the four highly selective compounds 15, 27, 41 and 47 inhibited EV71 replication with EC50 values of 0.17-0.02 mu M and SI values in range of 978.4-12338. A preliminary mechanistic study indicated that VP1 might be the target site for this type of compound.
• Rearrangement of arylhydrazones of aromatic and arylaliphatic carbonyl compounds to biphenyl derivatives. 3
  作者：R. Fusco、F. Sannicolo

  DOI：10.1021/jo00314a018

  日期：1981.1
• FUSCO R.; SANNICOLO F., J. ORG. CHEM., 1981, 46, NO 1, 83-89
  作者：FUSCO R.、 SANNICOLO F.

  DOI：——

  日期：——