N-(2,3-dichlorobenzyl)-N-(4,5-dihydrothiazol-2-yl)amine | 159091-94-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,3-dichlorobenzyl)-N-(4,5-dihydrothiazol-2-yl)amine
• 英文别名: ((2,3-dichlorophenyl)methyl)-(1,3-thiazolin-2-yl)amine；(2,3-dichloro-benzyl)-(4,5-dihydro-thiazol-2-yl)-amine；N-(2,3-dichlorobenzyl)-4,5-dihydrothiazol-2-amine；2-(2,3-Dichlorobenzylamino)-2-thiazoline；N-[(2,3-dichlorophenyl)methyl]-4,5-dihydro-1,3-thiazol-2-amine
• CAS: 159091-94-8
• 化学式: C₁₀H₁₀Cl₂N₂S
• 分子量: 261.175
• InChiKey: OXVDIAASMCZEFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  49.7
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  二碳酸二叔丁酯 、 N-(2,3-dichlorobenzyl)-N-(4,5-dihydrothiazol-2-yl)amine 在 水 、 Sodium sulfate-III 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 2-(2,3-dichlorobenzylimino)thiazolidin-3-ylcarboxylic acid tert-butyl ester
  参考文献：
  名称：

  Pesticidal Compositions

  摘要：

  本发明涉及1-(Azolin-2-yl)-amino-烷基化合物，其可用于对抗昆虫、蜘蛛和线虫。本发明还涉及一种用于对抗昆虫、蜘蛛和线虫等动物害虫的方法，以及用于对抗动物害虫的农业组合物。发现可以通过通式I中的1-(Azolin-2-yl)-amino-烷基化合物对动物害虫进行对抗，其中A是式A1或A2的基团：X是硫或氧，W、B和R1至R6如描述中所定义。

  公开号：

  US20080312085A1
• 作为产物：
  描述：

  2,3-二氯苄胺 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 乙醚 、 水 为溶剂， 反应 18.17h， 生成 N-(2,3-dichlorobenzyl)-N-(4,5-dihydrothiazol-2-yl)amine
  参考文献：
  名称：

  [EN] INSECTICIDAL SUBSTITUTED BENZYLAMINO HETEROCYCLIC AND HETEROARYL DERIVATIVES
  [FR] DERIVES HETEROCYLIQUES ET HETEROARYLE INSECTICIDE A SUBSTITUTION BENZYLAMINO

  摘要：

  公开号：

  WO2006127426A3

文献信息

• Selective Alpha 2B/2C Agonists
  申请人：Nguyen Phong X.

  公开号：US20110028523A1

  公开（公告）日：2011-02-03

  Described herein are compounds useful as agonists of alpha 2B/2C receptors. Pharmaceutical compositions including the presently described compounds and methods of treatment of diseases and conditions with the presently described compounds also are disclosed.

  本文描述了作为α2B/2C受体激动剂有用的化合物。还披露了包括目前描述的化合物在内的药物组合物，以及使用目前描述的化合物治疗疾病和病况的方法。
• [EN] AZOLIN-2-YLAMINO COMPOUNDS FOR COMBATING ANIMAL PESTS<br/>[FR] COMPOSÉS AZOLIN-2-YLAMINO POUR LUTTER CONTRE DES ANIMAUX NUISIBLES
  申请人：BASF SE

  公开号：WO2009115491A1

  公开（公告）日：2009-09-24

  The present invention relates to azolin-2-ylamino compounds of formulae (I) and (II), wherein n is 0 to 3; Ar is phenyl; A is a radical of formulae A1 or A2, wherein * indicates the point of attachment; X is S, O or N(R10); R7a-d are H, halogen, C1-C6-alkyl, C1-C6-alkoxy, C1-C6-alkylamino or C3-C6-cycloalkyl; R8-10 are H, CN, NO2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, Ar3, -B-C(=O)Ra, -B-C(=S)Ra, -B-C(=NRf)Ra, etc., wherein B is a single bond or C1-C4-alkanediyl; R1 is H, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, phenyl or benzyl; R2,3 are H, halogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C6-cycloalkyl, phenyl or benzyl; R4 is H, halogen, CN, N3, NO2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, a heterocycle, Ar5, -C(=O)Ra, -C(=S)Ra, -C(=NRf)Ra, etc.; or R4 and R5 together form a carbocycle or heterocycle; R5,6 are H, halogen, CN, N3, NO2, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, heterocycle, Ar8, -C(=O)Ra, -C(=S)Ra, -C(=NRf)Ra, etc.; or R5 and R6 together form a carbocycle or heterocycle; Ra-h are H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, heterocycles or Ar10; Ar1 to 11 are phenyl, naphthyl or heteroaryl; and A' is a radical of formula A3, wherein W is halogen or OR11; R11 is H or -C(=O)-Ri; Ri is H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C3-C8-cycloalkyl, heterocycle or Ar12; and Ar12 is phenyl, naphthyl or heteroaryl; as well as to agricultural composition containing such compounds, the use of such compounds for controlling animal pests, seed, comprising such compounds, a method for controlling animal pests and a method for treating or protecting an animal from infestation or infection by parasites.

  本发明涉及式（I）和（II）的噻唑啉-2-基氨基化合物，其中n为0至3；Ar为苯基；A为式A1或A2的基团，其中*表示连接点；X为S、O或N(R10)；R7a-d为H、卤素、C1-C6-烷基、C1-C6-烷氧基、C1-C6-烷基氨基或C3-C6环烷基；R8-10为H、CN、NO2、C1-C6-烷基、C2-C6-烯基、C2-C6-炔基、C3-C8环烷基、Ar3、-B-C(=O)Ra、-B-C(=S)Ra、-B-C(=NRf)Ra等，其中B为单键或C1-C4烷二基；R1为H、卤素、C1-C6烷基、C2-C6-烯基、C2-C6-炔基、C3-C6环烷基、苯基或苄基；R2,3为H、卤素、C1-C6烷基、C2-C6-烯基、C2-C6-炔基、C3-C6环烷基、苯基或苄基；R4为H、卤素、CN、N3、 、C1-C6烷基、C2-C6-烯基、C2-C6-炔基、C3-C8环烷基、杂环、Ar5、-C(=O)Ra、-C(=S)Ra、-C(=NRf)Ra等；或R4和R5一起形成碳环或杂环；R5,6为H、卤素、CN、N3、 、C1-C6烷基、C2-C6-烯基、C2-C6-炔基、C3-C8环烷基、杂环、Ar8、-C(=O)Ra、-C(=S)Ra、-C(=NRf)Ra等；或R5和R6一起形成碳环或杂环；Ra-h为H、C1-C6烷基、C2-C6-烯基、C2-C6-炔基、C3-C8环烷基、杂环或Ar10；Ar1至11为苯基、萘基或杂环基；A'为式A3的基团，其中W为卤素或OR11；R11为H或-C(=O)-Ri；Ri为H、C1-C6烷基、C2-C6-烯基、C2-C6-炔基、C3-C8环烷基、杂环或Ar12；Ar12为苯基、萘基或杂环基；以及含有这种化合物的农业组合物，使用这种化合物控制动物害虫的方法，包括这种化合物的种子，控制动物害虫的方法以及治疗或保护动物免受寄生虫感染的方法。
• Insecticidal Substituted Benzylamino Heterocyclic and Heteroaryl Derivatives
  申请人：Dixson John A.

  公开号：US20090036306A1

  公开（公告）日：2009-02-05

  Certain substituted benzylamino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (1): wherein R, R1, R2, R3, and R4 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (1), and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  某些取代苯基氨基的杂环和杂环芳基衍生物具有出乎意料的杀虫和杀螨活性。这些化合物由公式(1)表示:其中R、R1、R2、R3和R4在此完整描述。此外，还公开了包含公式(1)中至少一种化合物的杀虫有效量的组合物，以及可选地，至少一种附加化合物的有效量，与至少一种杀虫兼容载体的组合物;以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预计存在的地点。
• Insecticidal substituted benzylamino heterocyclic and heteroaryl derivatives
  申请人：FMC Corporation

  公开号：US08193118B2

  公开（公告）日：2012-06-05

  Certain substituted benzylamino heterocyclic and heteroaryl derivatives have provided unexpected insecticidal and acaricidal activity. These compounds are represented by formula (I): wherein R, R1, R2, R3, and R4 are fully described herein. In addition, compositions comprising an insecticidally effective amount of at least one compound of formula (I), and optionally, an effective amount of at least one of an additional compound, with at least one insecticidally compatible carrier are also disclosed; along with methods of controlling insects comprising applying said compositions to a locus where insects are present or are expected to be present.

  某些取代苯基氨基杂环和杂环基衍生物具有出乎意料的杀虫和杀螨活性。这些化合物由公式（I）表示：其中R，R1，R2，R3和R4在此完整描述。此外，还公开了包含公式（I）至少一种化合物的杀虫有效量的组合物，以及可选地，至少一种额外化合物的有效量，与至少一种杀虫相容的载体;以及控制昆虫的方法，包括将所述组合物应用于昆虫存在或预期存在的地点。
• Novel methods and compositions for alleviating pain
  申请人：Allergan, Inc.

  公开号：EP2351561A2

  公开（公告）日：2011-08-03

  The present invention provides a method for the long-term relief of chronic pain in a subject by activating in the subject an analgesic alpha-adrenergic receptor in the absence of alpha-2A receptor activation over a period of at least three days, such that relief of chronic pain is maintained in the absence of continued activation of said receptor. The analgesic alpha-adrenergic receptor can be, for example, the alpha-2B receptor.

  本发明提供了一种长期缓解受试者慢性疼痛的方法，在α-2A受体未被激活的情况下，激活受试者体内的镇痛剂α-肾上腺素能受体至少三天，从而在所述受体未被持续激活的情况下保持慢性疼痛的缓解。镇痛的α-肾上腺素能受体可以是α-2B受体等。