Ethyl 2--3-oxobutyrate | 86953-85-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: Ethyl 2--3-oxobutyrate
• 英文别名: Tert-butyl 2-(1-ethoxy-1,3-dioxobutan-2-yl)pyrrolidine-1-carboxylate
• CAS: 86953-85-7
• 化学式: C₁₅H₂₅NO₅
• 分子量: 299.367
• InChiKey: PCXLTMRMQQTDEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-Boc-四氢吡咯 在 哌啶 作用下， 以 乙醇 、 水 、 乙腈 为溶剂， 生成 Ethyl 2--3-oxobutyrate
  参考文献：
  名称：

  Palladium-catalyzed carbonylation. A new synthesis of .alpha.-methylene .gamma.-, .delta.-, .epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine and indolizidine skeletons

  摘要：

  DOI：

  10.1021/jo00170a037

文献信息

• Addition of carbon nucleophiles to cyclic N-acyliminium ions in SDS/water
  作者：Nilton Soares Camilo、Ronaldo Aloise Pilli

  DOI：10.1016/j.tetlet.2004.02.009

  日期：2004.3

  The acid-catalyzed addition of 1,3-dicarbonyl compounds and activated olefins (silyl enol ethers and ethyl vinyl ether) to N-Boc-2-methoxypyrrolidine (1a) and N-Boc-2-methoxypiperidine (1b) in SDS/water medium is described. Good yields of the corresponding 2-substituted N-Boc pyrrolidines were generally observed from 1a while moderate yields prevailed from 1b.

  在SDS /水中的N - Boc-2-甲氧基吡咯烷（1a）和N -Boc-2-甲氧基吡咯烷（1b）中将1,3-二羰基化合物和活化的烯烃（甲硅烷基醚和乙基乙烯基醚）酸催化加成描述了媒体。通常从1a观察到相应的2-取代的N - Boc吡咯烷的良好产率，而从1b起普遍获得中等产率。
• Addition of carbon nucleophiles to cyclic N-acyliminium and oxocarbenium ions under solvent-free conditions
  作者：Luiz Antonio F. de Godoy、Nilton Soares Camilo、Ronaldo Aloise Pilli

  DOI：10.1016/j.tetlet.2006.09.023

  日期：2006.11

  The InCl3-catalyzed addition of carbon nucleophiles to cyclic N-acyliminium and oxocarbenium ions under solvent-free conditions at room temperature is described. The corresponding-substituted heterocycles were obtained in moderate to excellent yields. (c) 2006 Elsevier Ltd. All rights reserved.
• MORI, MIWAKO;WASHIOKA, YUMIKO;URAYAMA, TAKAO;YOSHIURA, KAGARI;CHIBA, KATS+, J. ORG. CHEM., 1983, 48, N 22, 4058-4067
  作者：MORI, MIWAKO、WASHIOKA, YUMIKO、URAYAMA, TAKAO、YOSHIURA, KAGARI、CHIBA, KATS+

  DOI：——

  日期：——
• Palladium-catalyzed carbonylation. A new synthesis of .alpha.-methylene .gamma.-, .delta.-, .epsilon.-lactams and lactones including bicyclic lactams of pyrrolizidine and indolizidine skeletons
  作者：Miwako Mori、Yumiko Washioka、Takao Urayama、Kagari Yoshiura、Katsumi Chiba、Yoshio Ban

  DOI：10.1021/jo00170a037

  日期：1983.11