3-[7-amino-3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-6-yl]-phenol | 861249-79-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 3-[7-amino-3-(2-methoxy-phenyl)-pyrazolo[1,5-a]pyrimidin-6-yl]-phenol
• 英文别名: 3-[7-Amino-3-(2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-6-yl]phenol
• CAS: 861249-79-8
• 化学式: C₁₉H₁₆N₄O₂
• 分子量: 332.362
• InChiKey: SBMMPHAIPXXEHX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  85.7
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• Organic compounds
  申请人：Bold Guido

  公开号：US20050222171A1

  公开（公告）日：2005-10-06

  The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

  该发明涉及在激酶依赖性疾病的治疗中使用吡唑并[1,5a]嘧啶-7-基胺化合物及其盐，并用于制备用于治疗该类疾病的药物制剂，新型吡唑并[1,5a]嘧啶-7-基胺化合物，以及制备新型吡唑并[1,5a]嘧啶-7-基胺化合物的方法。
• [EN] PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES<br/>[FR] DERIVES DE PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DESTINES A ETRE UTILISES DANS LE TRAITEMENT DE MALADIES DEPENDANTES DE LA PROTEINE KINASE
  申请人：NOVARTIS AG

  公开号：WO2005070431A1

  公开（公告）日：2005-08-04

  The invention relates to the use of pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof in the treatment of kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds, and a process for the preparation of the novel pyrazolo[1,5a]pyrimidin-7-yl amine compounds.

  该发明涉及使用吡唑并[1,5a]嘧啶-7-基胺化合物及其盐来治疗激酶依赖性疾病，并用于制备用于治疗该疾病的制药制剂，新的吡唑并[1,5a]嘧啶-7-基胺化合物，以及制备新的吡唑并[1,5a]嘧啶-7-基胺化合物的方法。
• PYRAZOLO[1,5-A]PYRIMIDIN-7-YL-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES
  申请人：Novartis AG

  公开号：EP1708710A1

  公开（公告）日：2006-10-11
• USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS
  申请人：NOVARTIS AG

  公开号：EP1993552A2

  公开（公告）日：2008-11-26
• [EN] USE OF PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DERIVATIVES IN THE TREATMENT OF NEUROLOGICAL DISORDERS<br/>[FR] UTILISATION DE DERIVES DE PYRAZOLO[1,5A]PYRIMIDIN-7-YL AMINE DANS LE TRAITEMENT DE TROUBLES NEUROLOGIQUES
  申请人：NOVARTIS AG

  公开号：WO2007103432A2

  公开（公告）日：2007-09-13

  (EN) The invention relates to methods of using the compounds of the invention, including pyrazolo[1,5a]pyrimidin-7-yl amine compounds and salts thereof, as well as pharmaceutical compositions comprising the same, in the treatment of Eph receptor-related (e.g., neurological) injuries and disorders. The invention also relates to modulating the activity of an Eph receptor in a cell, stimulating neural regeneration, and reversing neuronal degeneration, by administering a compound of the invention to a cell or subject in an effective amount.(FR) La présente invention concerne des procédés d'utilisation des composés de l'invention, incluant des composés pyrazolo[1,5a]pyrimidin-7-yl amine et leurs sels, ainsi que des compositions pharmaceutiques les comprenant, dans le traitement de lésions et de troubles liés au récepteur de Eph (par exemple, neurologiques). L'invention concerne également la modulation de l'activité d'un récepteur Eph dans une cellule, la stimulation de la régénération neurale et l'inversion de la dégénérescence neuronale, par l'administration d'un composé de l'invention à une cellule ou à un patient en une quantité efficace.