(4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2-[2-(2,6-dichloroanilino)phenyl]acetic acid | 1191260-85-1

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 吗啡烷
• 英文名称: (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2-[2-(2,6-dichloroanilino)phenyl]acetic acid
• CAS: 1191260-85-1
• 化学式: C32H32Cl2N2O5
• 分子量: 595.5
• InChiKey: AXAWHZOFIIMOBF-RNWHKREASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  41
• 可旋转键数：
  5
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  88.1
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER
  申请人：Grünenthal GmbH

  公开号：EP3285746A1

  公开（公告）日：2018-02-28
• TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES
  申请人：Grünenthal GmbH

  公开号：EP3285747A1

  公开（公告）日：2018-02-28
• PROTECTING ORAL OVERDOSE WITH ABUSE DETERRENT IMMEDIATE RELEASE FORMULATIONS
  申请人：Grünenthal GmbH

  公开号：EP3346991A1

  公开（公告）日：2018-07-18
• [EN] TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES<br/>[FR] COMBINAISON INVIOLABLE DE DOSES FIXES PERMETTANT LA LIBÉRATION RAPIDE DE DEUX MÉDICAMENTS À PARTIR DE PARTICULES
  申请人：GRUENENTHAL GMBH

  公开号：WO2016170094A1

  公开（公告）日：2016-10-27

  The invention relates to a tamper-resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form according to the invention is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.
• [EN] TAMPER-RESISTANT FIXED DOSE COMBINATION PROVIDING FAST RELEASE OF TWO DRUGS FROM PARTICLES AND A POWDER<br/>[FR] COMBINAISON DE DOSE FIXE INVIOLABLE PERMETTANT LA LIBÉRATION RAPIDE DE DEUX MÉDICAMENTS À PARTIR DE PARTICULES ET D'UNE POUDRE
  申请人：GRUENENTHAL GMBH

  公开号：WO2016170095A1

  公开（公告）日：2016-10-27

  The invention relates to a tamper -resistant pharmaceutical dosage form comprising two pharmacologically active ingredients, wherein the dosage form provides under in vitro conditions fast release, preferably immediate release according to Ph. Eur., of both pharmacologically active ingredients. The dosage form according to the invention is useful for pharmaceutical combination therapy that is achieved by administering dosage forms containing more than one pharmacologically active ingredient as fixed-dose combinations.