1,6-bis(p-N,N-dimethylaminophenyl)hexa-1,3,5-triene | 120343-25-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,6-bis(p-N,N-dimethylaminophenyl)hexa-1,3,5-triene
• 英文别名: (all-E)-1,6-bis[4-(dimethylamino)phenyl]hexa-1,3,5-triene；Me2N-DPH；1,6-Bis(4''-dimethylaminophenyl)-hexa-1,3,5-triene；4-[(1E,3E,5E)-6-[4-(dimethylamino)phenyl]hexa-1,3,5-trienyl]-N,N-dimethylaniline
• CAS: 120343-25-1
• 化学式: C₂₂H₂₆N₂
• 分子量: 318.462
• InChiKey: JGQHLETVKDCCET-NRIIQWGUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,6-bis(p-N,N-dimethylaminophenyl)hexa-1,3,5-triene 在 硫酸 作用下， 以 乙醇 为溶剂， 生成 (all-E)-1,6-bis[4-(dimethylammonium)phenyl]hexa-1,3,5-triene bis(hydrogen sulfate)
  参考文献：
  名称：

  二苯基己三烯作为用于超灵敏荧光检测的光保护剂

  摘要：

  考虑到染料光稳定性对于单分子研究，荧光波动光谱和激光扫描显微镜特别重要，人们探索了精细的策略，通过选择性地淬灭激光染料若丹明123（Rh123）的第一个激发三重态来增强荧光信号。该策略是通过Dexter三重态能量转移淬灭T 1状态，同时应避免通过Förster或Dexter单重态能量转移对单峰态进行不期望的淬灭以及通过电子转移产生自由基。使用荧光相关光谱法在乙醇中测试了二苯基己三烯（DPH）作为一类新型的光保护剂的有益作用。的图书馆合成了具有供电子（二甲基氨基）和吸收性取代基（例如三氟甲基）的DPH，以优化电子性能。量子化学计算，光谱学和循环伏安法被用来确定电子性能。所计算的Ť 1的发射能量的Rh123和T 1的所有的激发能量DPH小号允许放能三重态能量转移到淬灭剂。母体化合物淬灭了几乎受扩散控制的Rh123的T 1状态（4.9×10 9 M -1s -1）。所有电子不足的DPH都通过减少

  DOI：

  10.1021/jp909033x
• 作为产物：
  描述：

  tributyl-chloro-[(E)-4-[tributyl(chloro)-lambda5-phosphanyl]but-2-enyl]-lambda5-phosphane 、 对二甲氨基苯甲醛 以21%的产率得到
  参考文献：
  名称：

  SPANGLER, CHARLES W.;MCCOY, RAY K.;DEMBEK, ALEXA A.;SAPOCHAK, LINDA S.;GA+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 151-154

  摘要：

  DOI：

文献信息

• Stilbene derivatives and their use for binding and imaging amyloid plaques
  申请人：Kung F. Hank

  公开号：US20060269474A1

  公开（公告）日：2006-11-30

  This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

  本发明涉及一种成像淀粉样沉积物的方法，以及标记化合物和制备标记化合物的方法，以用于成像淀粉样沉积物。此外，本发明还涉及化合物和制备化合物的方法，以抑制淀粉样蛋白聚集形成淀粉样沉积物，并将治疗剂递送到淀粉样沉积物的方法。
• Synthesis of Biphenyltrienes as Probes for β-Amyloid Plaques
  作者：Zhi-Ping Zhuang、Mei-Ping Kung、Hank F. Kung

  DOI：10.1021/jm051020k

  日期：2006.5.1

  We report a series of p-hydroxy-, p-amino-, p-monomethylamino-, and p-monofluoroethylamino-substituted biphenyltrienes that displayed high binding affinities to beta-amyloid plaques. In an in vitro binding assay using postmortem brain homogenates of Alzheimer's patients and [I-125] 9, the triene compounds showed excellent binding affinities. When labeled with suitable radionuclides, they are useful as in vivo imaging agents for detecting A beta plaques in the brains of Alzheimer's patients.
• Chain-length dependence of the third-order polarizability of disubstituted polyenes: effects of end groups and conjugation length
  作者：Germain Puccetti、Mireille Blanchard-Desce、Isabelle Ledoux、Jean Marie Lehn、Joseph Zyss

  DOI：10.1021/j100139a022

  日期：1993.9

  Various alpha,omega-disubstituted polyenes of increasing length and bearing various donor and acceptor end groups have been synthesized in order to investigate the cabin-length dependence of their second-order hyperpolarizability gamma. Both symmetric polyenes bearing electron-withdrawing or electron-donating end groups and asymmetric donor-acceptor (push-pull) polyenes have been studied for the same donor/acceptor couple. Values of gamma have been obtained through the electric field induced second-harmonic generation (EFISH) and the third-harmonic generation (THG) experimental techniques. In each series of homologous compounds, the lengthening of the polyenic conjugated path results in a sharp increase in gamma values. This behavior can be modeled by gamma = kn(a) relationships with respect to the number of n of conjugated double bonds of the polyenic chain. The exponent value (a) depends on the substitution pattern. The steepest increase of gamma is obtained when both end groups are electron donors. Very large values of gamma are found for the longest symmetric polyenes bearing strong electron donors. No saturation effect has been noticed within the molecule size range investigated (up to 40 angstrom).
• Spangler, Charles W.; McCoy, Ray K.; Dembek, Alexa A., Journal of the Chemical Society. Perkin transactions I, 1989, p. 151 - 154
  作者：Spangler, Charles W.、McCoy, Ray K.、Dembek, Alexa A.、Sapochak, Linda S.、Gates, Bradley D.

  DOI：——

  日期：——
• SPANGLER, CHARLES W.;MCCOY, RAY K.;DEMBEK, ALEXA A.;SAPOCHAK, LINDA S.;GA+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1989) N, C. 151-154
  作者：SPANGLER, CHARLES W.、MCCOY, RAY K.、DEMBEK, ALEXA A.、SAPOCHAK, LINDA S.、GA+

  DOI：——

  日期：——