tert-butyl N-(2-bromo-5-chlorophenyl)-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate | 880384-46-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tert-butyl N-(2-bromo-5-chlorophenyl)-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate
• CAS: 880384-46-3
• 化学式: C₁₆H₂₁BrClNO₄
• 分子量: 406.704
• InChiKey: YGUVQAMZGQMYPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl N-(2-bromo-5-chlorophenyl)-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate 在 potassium carbonate 作用下， 以 甲醇 为溶剂， 生成 (2-bromo-5-chlorophenyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  AN IMPROVED SYNTHESIS OFN-BOC PROTECTED ARYL AMINES

  摘要：

  There are several known methods of protecting amines as their Boc derivatives. For less nucleophilic amines such as aryl amines these methods often give poor yields and are generally not satisfactory. Here, Boc aryl amines are obtained by first introducing two Boc groups followed by selective removal of one of them. This procedure works well for a number highly sterically hindered substrates as well as electron deficient and electron rich aryl amines.

  DOI：

  10.1081/scc-100106036
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 2-溴-5-氯苯胺 以 四氢呋喃 为溶剂， 以100%的产率得到tert-butyl N-(2-bromo-5-chlorophenyl)-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate
  参考文献：
  名称：

  Short and Simple Preparation ofN-Boc-Protected Anthranilic Acidtert-Butyl Esters from 2-Bromo-Anilines

  摘要：

  本文描述了一种从邻溴苯胺制备二保护氨基苯甲酸衍生物的新型两步程序。

  DOI：

  10.1055/s-2005-921910

文献信息

• AN IMPROVED SYNTHESIS OF<i>N</i>-BOC PROTECTED ARYL AMINES
  作者：Shelley Darnbrough、Miljenko Mervic、Stephen M. Condon、Christopher J. Burns

  DOI：10.1081/scc-100106036

  日期：2001.1

  There are several known methods of protecting amines as their Boc derivatives. For less nucleophilic amines such as aryl amines these methods often give poor yields and are generally not satisfactory. Here, Boc aryl amines are obtained by first introducing two Boc groups followed by selective removal of one of them. This procedure works well for a number highly sterically hindered substrates as well as electron deficient and electron rich aryl amines.
• Short and Simple Preparation of<i>N</i>-Boc-Protected Anthranilic Acid<i>tert</i>-Butyl Esters from 2-Bromo-Anilines
  作者：Thomas Lübbers、Silvia Herzig、Stéphane Kritter、Nadine Marquardt、Jens-Uwe Peters、Silja Weber

  DOI：10.1055/s-2005-921910

  日期：——

  A novel two-step procedure for the preparation of diprotected anthranilic acid derivatives from ortho-bromoanilines is ­described.

  本文描述了一种从邻溴苯胺制备二保护氨基苯甲酸衍生物的新型两步程序。