9-aminopyrene-1,4,6-trisulfonic Acid | 169211-42-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 9-aminopyrene-1,4,6-trisulfonic Acid
• CAS: 169211-42-1
• 化学式: C₁₆H₁₁NO₉S₃
• 分子量: 457.5
• InChiKey: DIDIOPKMWHMWQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  214
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• [EN] NOVEL SUBSTITUTED PIPERIDONES AS HSP INDUCERS<br/>[FR] NOUVELLES PIPÉRIDONES SUBSTITUÉES EN TANT QU'INDUCTEURS DE HSP
  申请人：TORRENT PHARMACEUTICALS LTD

  公开号：WO2009004650A1

  公开（公告）日：2009-01-08

  The present invention relates to novel compounds of formula (I) or (II), their pharmaceutically acceptable salts and their hydrates, solvates, stereoisomers, conformers, tautomers, polymorphs and prodrugs and also pharmaceutically acceptable compositions containing them Wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification. The compounds of the present invention are HSP inducers and by virtue of this effect, useful for the treatment of various diseases accompanying pathological stress. The present invention also relates to a process for the preparation of the said novel compounds. The invention also relates to the use of the above-mentioned compounds for the preparation of medicament for use as pharmaceuticals.

  本发明涉及式(I)或(II)的新化合物，它们的药学上可接受的盐及其水合物、溶剂合物、立体异构体、构象异构体、互变异构体、多晶型和前药，以及含有它们的药学上可接受的组合物，其中R1、R2、R3、R4、R5、R6和R7如规范中所定义。本发明的化合物是HSP诱导剂，由于这种作用，对于治疗伴随病理性压力的各种疾病是有用的。本发明还涉及一种制备上述新化合物的方法。该发明还涉及上述化合物的用途，用于制备用作药物的药物。
• Novel green and orange fluorescent labels and their uses
  申请人：——

  公开号：US20040106806A1

  公开（公告）日：2004-06-03

  The present invention provides novel fluorescent compounds and covalent attachment chemistries which facilitate the use of these compounds as labels for ultrasensitive and quantitative flourescent detection of low levels of biomolecules. In a preferred embodiment, the flourescent labels of this invention are novel derivatives of the hydroxy-pyrene trisulphonic and disulphonic acids which may be used in any assay in which radioisotopes, colored dyes or other fluorescent molecules are currently used. Thus, for example, any assay using labeled antibodies, proteins, oligonucleotides or lipids, including fluorescent cell sorting, fluorescence microscopy (including dark-field microscopy), fluorescence polarization assays, ligand, receptor binding assays, receptor activation assays and diagnostic assays can benefit from use of the compounds disclosed herein.

  本发明提供了新型荧光化合物和共价连接化学品，这些化合物可作为标记物，用于超灵敏和定量检测低水平生物分子的荧光检测。在一种首选实施方式中，本发明的荧光标记物是羟基吡啶三磺酸和二磺酸的新型衍生物，可用于任何目前使用放射性同位素、有色染料或其他荧光分子的检测中。因此，例如，任何使用标记抗体、蛋白质、寡核苷酸或脂质的检测方法，包括荧光细胞分选、荧光显微镜（包括暗场显微镜）、荧光偏振测定、配体、受体结合测定、受体激活测定和诊断测定，都可以从本文所披露的化合物的使用中获益。
• METHOD OF PREPARING SUGAR CHAIN SAMPLE, SUGAR CHAIN SAMPLE, AND METHOD OF ANALYZING SUGAR CHAIN
  申请人：Shimaoka Hideyuki

  公开号：US20110089033A1

  公开（公告）日：2011-04-21

  A method of preparing a sugar chain sample, for reducing unreacted labeling reagent in a sample solution containing a labeled sugar chain, includes (process 1) a process of bringing the sample solution containing the labeled sugar chain into contact with monolithic silica, so as to allow the monolithic silica to adsorb a sugar chain component; (process 2) a process of washing the monolithic silica with a washing liquid; and (process 3) a process of bringing the monolithic silica into contact with an eluant, so as to elute the adsorbed sugar chain.

  一种制备糖链样品的方法，用于减少样品溶液中含有标记的糖链的未反应标记试剂，包括（过程1）将含有标记的糖链的样品溶液与单体硅胶接触，使单体硅胶吸附糖链成分；（过程2）用洗涤液洗涤单体硅胶；以及（过程3）将单体硅胶与洗脱剂接触，以洗脱吸附的糖链。
• Method for automated high throughput identification of carbohydrates and carbohydrate mixture composition patterns as well as systems therefore
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP2112506A1

  公开（公告）日：2009-10-28

  The present invention relates to methods for the identification of compounds in carbohydrate mixture compositions as well as the determination of carbohydrate mixture composition patterns, based on determining migration time (indices) using capillary gel electrophoresis- laser induced fluorescence and identifying said carbohydrate components based on comparing said migration time (indices) with standard migration time (indices) from a database. In a further aspect, the present invention relates to a method for carbohydrate mixture composition pattern profiling, like glycosylation pattern profiling using capillary gel electrophoresis- laser induced fluorescence (CGE-LIF). In another aspect, the present invention refers to a system for an automated determination and/or identification of carbohydrates and/or carbohydrate mixture composition patterns (e.g.: glycosylation patterns). Finally, the present invention relates to a database containing normalized migration times and/or migration time indices of carbohydrates.

  本发明涉及基于使用毛细管凝胶电泳-激光诱导荧光确定迁移时间（指数），并基于将所述迁移时间（指数）与数据库中的标准迁移时间（指数）进行比较来识别所述碳水化合物成分，从而鉴定碳水化合物混合物组合物中的化合物以及确定碳水化合物混合物组合物模式的方法。在另一个方面，本发明涉及一种碳水化合物混合物成分模式剖析方法，如使用毛细管凝胶电泳-激光诱导荧光（CGE-LIF）进行糖基化模式剖析。另一方面，本发明涉及一种自动测定和/或鉴定碳水化合物和/或碳水化合物混合物组成模式（如：糖基化模式）的系统。最后，本发明涉及一种包含碳水化合物归一化迁移时间和/或迁移时间指数的数据库。
• METHOD FOR PREPARATION OF SUGAR CHAIN SAMPLE, SUGAR CHAIN SAMPLE, AND METHOD FOR ANALYSIS OF SUGAR CHAIN
  申请人：Sumitomo Bakelite Co., Ltd.

  公开号：EP2295962A1

  公开（公告）日：2011-03-16

  A method of preparing a sugar chain sample, for reducing unreacted labeling reagent in a sample solution containing a labeled sugar chain, includes (process 1) a process of bringing the sample solution containing the labeled sugar chain into contact with monolithic silica, so as to allow the monolithic silica to adsorb a sugar chain component; (process 2) a process of washing the monolithic silica with a washing liquid; and (process 3) a process of bringing the monolithic silica into contact with an eluant, so as to elute the adsorbed sugar chain.

  一种制备糖链样品的方法，用于减少含有已标记糖链的样品溶液中未反应的标记试剂，包括（过程1）使含有已标记糖链的样品溶液与整体二氧化硅接触，从而使整体二氧化硅吸附糖链组分；(过程 2）用洗涤液洗涤整体二氧化硅；以及 过程 3）使整体二氧化硅与洗脱剂接触，以洗脱吸附的糖链。