2-(4-methyl-piperazin-1-yl)-4-o-tolyl-quinazoline | 14005-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-(4-methyl-piperazin-1-yl)-4-o-tolyl-quinazoline
• 英文别名: Quinazoline, 4-(2-methylphenyl)-2-(4-methyl-1-piperazinyl)-；4-(2-methylphenyl)-2-(4-methylpiperazin-1-yl)quinazoline
• CAS: 14005-56-2
• 化学式: C₂₀H₂₂N₄
• 分子量: 318.421
• InChiKey: LFAOKDNDTVBKQD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Novel norepinephrine reuptake inhibitors for the treatment of central nervous system disorders
  申请人：Caprathe William Bradley

  公开号：US20050096327A1

  公开（公告）日：2005-05-05

  This invention relates to compounds of the formula 1 wherein R 1 , R 2 , and R 3 and R 4 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.

  这项发明涉及公式1的化合物 其中R 1 ，R 2 ，R 3 和R 4 如规范中所定义，包含它们的药物组合物以及它们在治疗中枢神经系统疾病中的用途。
• NOVEL NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS
  申请人：Warner-Lambert Company LLC

  公开号：EP1685115A1

  公开（公告）日：2006-08-02
• [EN] NOVEL NOREPINEPHRINE REUPTAKE INHIBITORS FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS<br/>[FR] NOUVEAUX INHIBITEURS DU RECAPTAGE DE LA NOREPINEPHRINE POUR LE TRAITEMENT DES TROUBLES DU SYSTEME NERVEUX CENTRAL
  申请人：WARNER LAMBERT CO

  公开号：WO2005042501A1

  公开（公告）日：2005-05-12

  This invention relates to compounds of the formula (I), wherein R1, R2, and R3 and R4 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system disorders.